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185 related items for PubMed ID: 8394729

  • 1. Molecular mechanisms of SR 4233-induced hepatocyte toxicity under aerobic versus hypoxic conditions.
    Silva JM, O'Brien PJ.
    Br J Cancer; 1993 Sep; 68(3):484-91. PubMed ID: 8394729
    [Abstract] [Full Text] [Related]

  • 2. Molecular mechanisms of tirapazamine (SR 4233, Win 59075)-induced hepatocyte toxicity under low oxygen concentrations.
    Khan S, O'Brien PJ.
    Br J Cancer; 1995 Apr; 71(4):780-5. PubMed ID: 7710944
    [Abstract] [Full Text] [Related]

  • 3. Modulation of trenimon-induced cytotoxicity by DT-diaphorase in isolated rat hepatocytes under aerobic versus hypoxic conditions.
    Silva JM, Rao DN, O'Brien PJ.
    Cancer Res; 1992 Jun 01; 52(11):3015-21. PubMed ID: 1375532
    [Abstract] [Full Text] [Related]

  • 4. Enzymology of the reductive bioactivation of SR 4233. A novel benzotriazine di-N-oxide hypoxic cell cytotoxin.
    Walton MI, Workman P.
    Biochem Pharmacol; 1990 Jun 01; 39(11):1735-42. PubMed ID: 2344370
    [Abstract] [Full Text] [Related]

  • 5. Protection against SR 4233 (Tirapazamine) aerobic cytotoxicity by the metal chelators desferrioxamine and tiron.
    Herscher LL, Krishna MC, Cook JA, Coleman CN, Biaglow JE, Tuttle SW, Gonzalez FJ, Mitchell JB.
    Int J Radiat Oncol Biol Phys; 1994 Nov 15; 30(4):879-85. PubMed ID: 7960991
    [Abstract] [Full Text] [Related]

  • 6. Contrasting molecular cytotoxic mechanisms of mitomycin C and its two analogs, BMY 25282 and BMY 25067, in isolated rat hepatocytes.
    Silva JM, Khan S, O'Brien PJ.
    Biochem Pharmacol; 1993 Jun 09; 45(11):2303-9. PubMed ID: 8517871
    [Abstract] [Full Text] [Related]

  • 7. Adaptation of human tumor cells to tirapazamine under aerobic conditions: implications of increased antioxidant enzyme activity to mechanism of aerobic cytotoxicity.
    Elwell JH, Siim BG, Evans JW, Brown JM.
    Biochem Pharmacol; 1997 Jul 15; 54(2):249-57. PubMed ID: 9271329
    [Abstract] [Full Text] [Related]

  • 8. Initial characterization of the major mouse cytochrome P450 enzymes involved in the reductive metabolism of the hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, SR 4233, WIN 59075).
    Riley RJ, Hemingway SA, Graham MA, Workman P.
    Biochem Pharmacol; 1993 Mar 09; 45(5):1065-77. PubMed ID: 8461036
    [Abstract] [Full Text] [Related]

  • 9. Nitrofurantoin-mediated oxidative stress cytotoxicity in isolated rat hepatocytes.
    Rossi L, Silva JM, McGirr LG, O'Brien PJ.
    Biochem Pharmacol; 1988 Aug 15; 37(16):3109-17. PubMed ID: 3401242
    [Abstract] [Full Text] [Related]

  • 10. Quinone toxicity in hepatocytes without oxidative stress.
    Rossi L, Moore GA, Orrenius S, O'Brien PJ.
    Arch Biochem Biophys; 1986 Nov 15; 251(1):25-35. PubMed ID: 3789732
    [Abstract] [Full Text] [Related]

  • 11. In vitro hepatotoxicity of SR 4233 (3-amino-1,2,4-benzotriazine-1,4-dioxide), a hypoxic cytotoxin and potential antitumor agent.
    Costa AK, Baker MA, Brown JM, Trudell JR.
    Cancer Res; 1989 Feb 15; 49(4):925-9. PubMed ID: 2912562
    [Abstract] [Full Text] [Related]

  • 12. Mechanism for the hepatotoxicity of the antiandrogen, nilutamide. Evidence suggesting that redox cycling of this nitroaromatic drug leads to oxidative stress in isolated hepatocytes.
    Fau D, Berson A, Eugene D, Fromenty B, Fisch C, Pessayre D.
    J Pharmacol Exp Ther; 1992 Oct 15; 263(1):69-77. PubMed ID: 1403804
    [Abstract] [Full Text] [Related]

  • 13. Structure-activity relationships for benzotriazine di-N-oxides.
    Zeman EM, Baker MA, Lemmon MJ, Pearson CI, Adams JA, Brown JM, Lee WW, Tracy M.
    Int J Radiat Oncol Biol Phys; 1989 Apr 15; 16(4):977-81. PubMed ID: 2703405
    [Abstract] [Full Text] [Related]

  • 14.
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  • 15. Toxicity of nitrobenzene compounds towards isolated hepatocytes: dependence on reduction potential.
    O'Brien PJ, Wong WC, Silva J, Khan S.
    Xenobiotica; 1990 Sep 15; 20(9):945-55. PubMed ID: 2238713
    [Abstract] [Full Text] [Related]

  • 16. Bioreductive metabolism of SR-4233 (WIN 59075) by whole cell suspensions under aerobic and hypoxic conditions: role of the pentose cycle and implications for the mechanism of cytotoxicity observed in air.
    Tuttle SW, Hazard L, Koch CJ, Mitchell JB, Coleman CN, Biaglow JE.
    Int J Radiat Oncol Biol Phys; 1994 May 15; 29(2):357-62. PubMed ID: 8195033
    [Abstract] [Full Text] [Related]

  • 17. Genotoxic effects of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) and nitrogen mustard-N-oxide (nitromin) in Walker carcinoma cells under aerobic and hypoxic conditions.
    Cahill A, Jenkins TC, Pickering P, White IN.
    Chem Biol Interact; 1995 Mar 30; 95(1-2):97-107. PubMed ID: 7697757
    [Abstract] [Full Text] [Related]

  • 18. Modulating hypoxia-induced hepatocyte injury by affecting intracellular redox state.
    Khan S, O'Brien PJ.
    Biochim Biophys Acta; 1995 Nov 09; 1269(2):153-61. PubMed ID: 7488648
    [Abstract] [Full Text] [Related]

  • 19. Selective potentiation of the hypoxic cytotoxicity of tirapazamine by its 1-N-oxide metabolite SR 4317.
    Siim BG, Pruijn FB, Sturman JR, Hogg A, Hay MP, Brown JM, Wilson WR.
    Cancer Res; 2004 Jan 15; 64(2):736-42. PubMed ID: 14744792
    [Abstract] [Full Text] [Related]

  • 20. Phenylenediamine induced hepatocyte cytotoxicity redox. Cycling mediated oxidative stress without oxygen activation.
    Sood C, Khan S, O'Brien PJ.
    Biochim Biophys Acta; 1997 Jun 06; 1335(3):343-52. PubMed ID: 9202197
    [Abstract] [Full Text] [Related]

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