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517 related items for PubMed ID: 8395332

  • 1. Resistance to aflatoxin B1 is associated with the expression of a novel aldo-keto reductase which has catalytic activity towards a cytotoxic aldehyde-containing metabolite of the toxin.
    Hayes JD, Judah DJ, Neal GE.
    Cancer Res; 1993 Sep 01; 53(17):3887-94. PubMed ID: 8395332
    [Abstract] [Full Text] [Related]

  • 2. Modulation of aflatoxin metabolism, aflatoxin-N7-guanine formation, and hepatic tumorigenesis in rats fed ethoxyquin: role of induction of glutathione S-transferases.
    Kensler TW, Egner PA, Davidson NE, Roebuck BD, Pikul A, Groopman JD.
    Cancer Res; 1986 Aug 01; 46(8):3924-31. PubMed ID: 2873884
    [Abstract] [Full Text] [Related]

  • 3. Regulation of glutathione S-transferases and aldehyde reductase by chemoprotectors: studies of mechanisms responsible for inducible resistance to aflatoxin B1.
    Hayes JD, McLeod R, Ellis EM, Pulford DJ, Ireland LS, McLellan LI, Judah DJ, Manson MM, Neal GE.
    IARC Sci Publ; 1996 Aug 01; (139):175-87. PubMed ID: 8923030
    [Abstract] [Full Text] [Related]

  • 4. Metabolic basis for the protective effect of the antioxidant ethoxyquin on aflatoxin B1 hepatocarcinogenesis in the rat.
    Mandel HG, Manson MM, Judah DJ, Simpson JL, Green JA, Forrester LM, Wolf CR, Neal GE.
    Cancer Res; 1987 Oct 01; 47(19):5218-23. PubMed ID: 2887284
    [Abstract] [Full Text] [Related]

  • 5. Protection conferred by selenium deficiency against aflatoxin B1 in the rat is associated with the hepatic expression of an aldo-keto reductase and a glutathione S-transferase subunit that metabolize the mycotoxin.
    McLeod R, Ellis EM, Arthur JR, Neal GE, Judah DJ, Manson MM, Hayes JD.
    Cancer Res; 1997 Oct 01; 57(19):4257-66. PubMed ID: 9331086
    [Abstract] [Full Text] [Related]

  • 6. Regulation of aflatoxin B1-metabolizing aldehyde reductase and glutathione S-transferase by chemoprotectors.
    McLellan LI, Judah DJ, Neal GE, Hayes JD.
    Biochem J; 1994 May 15; 300 ( Pt 1)(Pt 1):117-24. PubMed ID: 8198522
    [Abstract] [Full Text] [Related]

  • 7. Ethoxyquin-induced resistance to aflatoxin B1 in the rat is associated with the expression of a novel alpha-class glutathione S-transferase subunit, Yc2, which possesses high catalytic activity for aflatoxin B1-8,9-epoxide.
    Hayes JD, Judah DJ, McLellan LI, Kerr LA, Peacock SD, Neal GE.
    Biochem J; 1991 Oct 15; 279 ( Pt 2)(Pt 2):385-98. PubMed ID: 1953636
    [Abstract] [Full Text] [Related]

  • 8. Comparative activities of glutathione-S-transferase and dialdehyde reductase toward aflatoxin B1 in livers of experimental and farm animals.
    Tulayakul P, Sakuda S, Dong KS, Kumagai S.
    Toxicon; 2005 Aug 15; 46(2):204-9. PubMed ID: 15964045
    [Abstract] [Full Text] [Related]

  • 9. An ethoxyquin-inducible aldehyde reductase from rat liver that metabolizes aflatoxin B1 defines a subfamily of aldo-keto reductases.
    Ellis EM, Judah DJ, Neal GE, Hayes JD.
    Proc Natl Acad Sci U S A; 1993 Nov 01; 90(21):10350-4. PubMed ID: 8234296
    [Abstract] [Full Text] [Related]

  • 10. Chemoprevention of aflatoxin B1 hepatocarcinogenesis by coumarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:quinone oxidoreductase in rat liver.
    Kelly VP, Ellis EM, Manson MM, Chanas SA, Moffat GJ, McLeod R, Judah DJ, Neal GE, Hayes JD.
    Cancer Res; 2000 Feb 15; 60(4):957-69. PubMed ID: 10706111
    [Abstract] [Full Text] [Related]

  • 11. Indole-3-carbinol induces a rat liver glutathione transferase subunit (Yc2) with high activity toward aflatoxin B1 exo-epoxide. Association with reduced levels of hepatic aflatoxin-DNA adducts in vivo.
    Stresser DM, Williams DE, McLellan LI, Harris TM, Bailey GS.
    Drug Metab Dispos; 1994 Feb 15; 22(3):392-9. PubMed ID: 8070315
    [Abstract] [Full Text] [Related]

  • 12. Protection against aflatoxin B1-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz): predictive role for short-term molecular dosimetry.
    Roebuck BD, Liu YL, Rogers AE, Groopman JD, Kensler TW.
    Cancer Res; 1991 Oct 15; 51(20):5501-6. PubMed ID: 1680553
    [Abstract] [Full Text] [Related]

  • 13. Purification from rat liver of a novel constitutively expressed member of the aldo-keto reductase 7 family that is widely distributed in extrahepatic tissues.
    Kelly VP, Ireland LS, Ellis EM, Hayes JD.
    Biochem J; 2000 Jun 01; 348 Pt 2(Pt 2):389-400. PubMed ID: 10816434
    [Abstract] [Full Text] [Related]

  • 14. Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones.
    Kensler TW, Egner PA, Dolan PM, Groopman JD, Roebuck BD.
    Cancer Res; 1987 Aug 15; 47(16):4271-7. PubMed ID: 2886217
    [Abstract] [Full Text] [Related]

  • 15. cDNA cloning, expression and activity of a second human aflatoxin B1-metabolizing member of the aldo-keto reductase superfamily, AKR7A3.
    Knight LP, Primiano T, Groopman JD, Kensler TW, Sutter TR.
    Carcinogenesis; 1999 Jul 15; 20(7):1215-23. PubMed ID: 10383892
    [Abstract] [Full Text] [Related]

  • 16. Regulation of rat glutathione S-transferase A5 by cancer chemopreventive agents: mechanisms of inducible resistance to aflatoxin B1.
    Hayes JD, Pulford DJ, Ellis EM, McLeod R, James RF, Seidegård J, Mosialou E, Jernström B, Neal GE.
    Chem Biol Interact; 1998 Apr 24; 111-112():51-67. PubMed ID: 9679543
    [Abstract] [Full Text] [Related]

  • 17. Temporal patterns of DNA adduct formation and glutathione S-transferase activity in the testes of rats fed aflatoxin B1: a comparison with patterns in the liver.
    Sotomayor RE, Sahu S, Washington M, Hinton DM, Chou M.
    Environ Mol Mutagen; 1999 Apr 24; 33(4):293-302. PubMed ID: 10398377
    [Abstract] [Full Text] [Related]

  • 18. Low hepatic glutathione S-transferase and increased hepatic DNA adduction contribute to increased tumorigenicity of aflatoxin B1 in newborn and partially hepatectomized mice.
    Shupe T, Sell S.
    Toxicol Lett; 2004 Mar 14; 148(1-2):1-9. PubMed ID: 15019083
    [Abstract] [Full Text] [Related]

  • 19. Evaluation of the cancer chemopreventive potency of dithiolethione analogs of oltipraz.
    Roebuck BD, Curphey TJ, Li Y, Baumgartner KJ, Bodreddigari S, Yan J, Gange SJ, Kensler TW, Sutter TR.
    Carcinogenesis; 2003 Dec 14; 24(12):1919-28. PubMed ID: 14555609
    [Abstract] [Full Text] [Related]

  • 20. A novel aldehyde reductase with activity towards a metabolite of aflatoxin B1 is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidant.
    Judah DJ, Hayes JD, Yang JC, Lian LY, Roberts GC, Farmer PB, Lamb JH, Neal GE.
    Biochem J; 1993 May 15; 292 ( Pt 1)(Pt 1):13-8. PubMed ID: 8503840
    [Abstract] [Full Text] [Related]

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