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168 related items for PubMed ID: 8440739

  • 1. Characterization of a lipophilic antifolate resistance provoked by treatment of mammalian cells with the antiparasitic agent pyrimethamine.
    Assaraf YG, Slotky JI.
    J Biol Chem; 1993 Feb 25; 268(6):4556-66. PubMed ID: 8440739
    [Abstract] [Full Text] [Related]

  • 2. Characterization by flow cytometry and fluorescein-methotrexate labeling of hydrophilic and lipophilic antifolate resistance in cultured mammalian cells.
    Assaraf YG.
    Anticancer Drugs; 1993 Oct 25; 4(5):535-44. PubMed ID: 8292810
    [Abstract] [Full Text] [Related]

  • 3. Sequential amplification of dihydrofolate reductase and multidrug resistance genes in Chinese hamster ovary cells selected for stepwise resistance to the lipid-soluble antifolate trimetrexate.
    Assaraf YG, Molina A, Schimke RT.
    J Biol Chem; 1989 Nov 05; 264(31):18326-34. PubMed ID: 2572592
    [Abstract] [Full Text] [Related]

  • 4. Loss of folic acid exporter function with markedly augmented folate accumulation in lipophilic antifolate-resistant mammalian cells.
    Assaraf YG, Goldman ID.
    J Biol Chem; 1997 Jul 11; 272(28):17460-6. PubMed ID: 9211890
    [Abstract] [Full Text] [Related]

  • 5. Differential reversal of lipophilic antifolate resistance in mammalian cells with modulators of the multidrug resistance phenotype.
    Assaraf YG, Borgnia MJ.
    Anticancer Drugs; 1993 Jun 11; 4(3):395-406. PubMed ID: 8102912
    [Abstract] [Full Text] [Related]

  • 6. Characterization of the coexisting multiple mechanisms of methotrexate resistance in mouse 3T6 R50 fibroblasts.
    Assaraf YG, Feder JN, Sharma RC, Wright JE, Rosowsky A, Shane B, Schimke RT.
    J Biol Chem; 1992 Mar 25; 267(9):5776-84. PubMed ID: 1372892
    [Abstract] [Full Text] [Related]

  • 7. Multiple mechanisms of resistance to polyglutamatable and lipophilic antifolates in mammalian cells: role of increased folylpolyglutamylation, expanded folate pools, and intralysosomal drug sequestration.
    Jansen G, Barr H, Kathmann I, Bunni MA, Priest DG, Noordhuis P, Peters GJ, Assaraf YG.
    Mol Pharmacol; 1999 Apr 25; 55(4):761-9. PubMed ID: 10101035
    [Abstract] [Full Text] [Related]

  • 8. Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
    Diddens H, Niethammer D, Jackson RC.
    Cancer Res; 1983 Nov 25; 43(11):5286-92. PubMed ID: 6225514
    [Abstract] [Full Text] [Related]

  • 9. A phenotype conferring selective resistance to lipophilic antifolates in Chinese hamster ovary cells.
    Sharma RC, Assaraf YG, Schimke RT.
    Cancer Res; 1991 Jun 01; 51(11):2949-59. PubMed ID: 1674447
    [Abstract] [Full Text] [Related]

  • 10. Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates.
    Bram E, Ifergan I, Shafran A, Berman B, Jansen G, Assaraf YG.
    Cancer Chemother Pharmacol; 2006 Dec 01; 58(6):826-34. PubMed ID: 16612649
    [Abstract] [Full Text] [Related]

  • 11. Expression of variant dihydrofolate reductase with decreased binding affinity to antifolates in MOLT-3 human leukemia cell lines resistant to trimetrexate.
    Miyachi H, Takemura Y, Kobayashi H, Ando Y.
    Cancer Lett; 1995 Jan 06; 88(1):93-9. PubMed ID: 7850779
    [Abstract] [Full Text] [Related]

  • 12. Folate transport and the modulation of antifolate sensitivity in a methotrexate-resistant human breast cancer cell line.
    Dixon KH, Trepel JB, Eng SC, Cowan KH.
    Cancer Commun; 1991 Jan 06; 3(12):357-65. PubMed ID: 16296001
    [Abstract] [Full Text] [Related]

  • 13. Selective toxicity of a new lipophilic antifolate, BW301U, for methotrexate-resistant cells with reduced drug uptake.
    Taylor IW, Slowiaczek P, Friedlander ML, Tattersall MH.
    Cancer Res; 1985 Mar 06; 45(3):978-82. PubMed ID: 3971388
    [Abstract] [Full Text] [Related]

  • 14. Biochemical correlates of responsiveness and collateral sensitivity of some methotrexate-resistant murine tumors to the lipophilic antifolate, metoprine.
    Sirotnak FM, Moccio DM, Goutas LJ, Kelleher LE, Montgomery JA.
    Cancer Res; 1982 Mar 06; 42(3):924-8. PubMed ID: 7059991
    [Abstract] [Full Text] [Related]

  • 15. Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines.
    Liani E, Rothem L, Bunni MA, Smith CA, Jansen G, Assaraf YG.
    Int J Cancer; 2003 Feb 20; 103(5):587-99. PubMed ID: 12494465
    [Abstract] [Full Text] [Related]

  • 16. Inhibition of dihydrofolate reductase and cell growth by antifolates in a methotrexate-resistant cell line.
    Hamrell MR.
    Oncology; 1984 Feb 20; 41(5):343-8. PubMed ID: 6540852
    [Abstract] [Full Text] [Related]

  • 17. Allelic variation in the dihydrofolate reductase gene at amino acid position 95 contributes to antifolate resistance in Chinese hamster cells.
    Yu M, Melera PW.
    Cancer Res; 1993 Dec 15; 53(24):6031-5. PubMed ID: 8261418
    [Abstract] [Full Text] [Related]

  • 18. Selection for methotrexate resistance in mammalian cells bearing a Drosophila dihydrofolate reductase transgene: Methotrexate resistance in transgenic mammalian cells.
    Affleck JG, Nowickyj SM, Walker VK.
    Cell Biol Toxicol; 2010 Apr 15; 26(2):117-26. PubMed ID: 19337845
    [Abstract] [Full Text] [Related]

  • 19. Flow cytometric characterization of antifolate resistance in cultured mammalian cells using fluoresceinated methotrexate and daunorubicin.
    Sherwood SW, Assaraf YG, Molina A, Schimke RT.
    Cancer Res; 1990 Aug 15; 50(16):4946-50. PubMed ID: 2143099
    [Abstract] [Full Text] [Related]

  • 20. Molecular dynamics of interactions between rigid and flexible antifolates and dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant Plasmodium falciparum.
    Mokmak W, Chunsrivirot S, Hannongbua S, Yuthavong Y, Tongsima S, Kamchonwongpaisan S.
    Chem Biol Drug Des; 2014 Oct 15; 84(4):450-61. PubMed ID: 24716467
    [Abstract] [Full Text] [Related]

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