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95 related items for PubMed ID: 8461303

  • 1. Design of a linker for trivalent thrombin inhibitors: interaction of the main chain of the linker with thrombin.
    Szewczuk Z, Gibbs BF, Yue SY, Purisima E, Zdanov A, Cygler M, Konishi Y.
    Biochemistry; 1993 Apr 06; 32(13):3396-404. PubMed ID: 8461303
    [Abstract] [Full Text] [Related]

  • 2. Design of potent bivalent thrombin inhibitors based on hirudin sequence: incorporation of nonsubstrate-type active site inhibitors.
    Tsuda Y, Cygler M, Gibbs BF, Pedyczak A, Féthière J, Yue SY, Konishi Y.
    Biochemistry; 1994 Dec 06; 33(48):14443-51. PubMed ID: 7981204
    [Abstract] [Full Text] [Related]

  • 3. Molecular dynamics simulations of thrombin inhibitors at the S' subsites of thrombin.
    Yue SY, Konishi Y.
    Drug Des Discov; 1994 Jul 06; 12(1):1-17. PubMed ID: 7578804
    [Abstract] [Full Text] [Related]

  • 4. Bifunctional thrombin inhibitors based on the sequence of hirudin45-65.
    DiMaio J, Gibbs B, Munn D, Lefebvre J, Ni F, Konishi Y.
    J Biol Chem; 1990 Dec 15; 265(35):21698-703. PubMed ID: 2254323
    [Abstract] [Full Text] [Related]

  • 5. Interactions of hirudin-based inhibitor with thrombin: critical role of the IleH59 side chain of the inhibitor.
    Tsuda Y, Szewczuk Z, Wang J, Yue SY, Purisima E, Konishi Y.
    Biochemistry; 1995 Jul 11; 34(27):8708-14. PubMed ID: 7612610
    [Abstract] [Full Text] [Related]

  • 6. Bifunctional peptide boronate inhibitors of thrombin: crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide.
    Skordalakes E, Elgendy S, Goodwin CA, Green D, Scully MF, Kakkar VV, Freyssinet JM, Dodson G, Deadman JJ.
    Biochemistry; 1998 Oct 13; 37(41):14420-7. PubMed ID: 9772168
    [Abstract] [Full Text] [Related]

  • 7. A new class of potent thrombin inhibitors that incorporates a scissile pseudopeptide bond.
    DiMaio J, Ni F, Gibbs B, Konishi Y.
    FEBS Lett; 1991 Apr 22; 282(1):47-52. PubMed ID: 2026264
    [Abstract] [Full Text] [Related]

  • 8. Chemical compensation in macromolecular bridge-binding to thrombin.
    Hopfner KP, Ayala Y, Szewczuk Z, Konishi Y, Di Cera E.
    Biochemistry; 1993 Mar 30; 32(12):2947-53. PubMed ID: 8457559
    [Abstract] [Full Text] [Related]

  • 9. Nonpolar interactions of thrombin S' subsites with its bivalent inhibitor: methyl scan of the inhibitor linker.
    Slon-Usakiewicz JJ, Purisima E, Tsuda Y, Sulea T, Pedyczak A, Féthière J, Cygler M, Konishi Y.
    Biochemistry; 1997 Nov 04; 36(44):13494-502. PubMed ID: 9354617
    [Abstract] [Full Text] [Related]

  • 10. Synthesis, structure, and structure-activity relationships of divalent thrombin inhibitors containing an alpha-keto-amide transition-state mimetic.
    Krishnan R, Tulinsky A, Vlasuk GP, Pearson D, Vallar P, Bergum P, Brunck TK, Ripka WC.
    Protein Sci; 1996 Mar 04; 5(3):422-33. PubMed ID: 8868478
    [Abstract] [Full Text] [Related]

  • 11. Structural and Functional Characterization of Hirudin P6 Derived Novel Bivalent Thrombin Inhibitors - Studying the Effect of Linker Length and Glycosylation on Their Function.
    Shabareesh P, Kaur KJ.
    Chem Biol Drug Des; 2016 Jul 04; 88(1):129-41. PubMed ID: 26850929
    [Abstract] [Full Text] [Related]

  • 12. Design of P1' and P3' residues of trivalent thrombin inhibitors and their crystal structures.
    Slon-Usakiewicz JJ, Sivaraman J, Li Y, Cygler M, Konishi Y.
    Biochemistry; 2000 Mar 07; 39(9):2384-91. PubMed ID: 10694407
    [Abstract] [Full Text] [Related]

  • 13. Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6.
    Zdanov A, Wu S, DiMaio J, Konishi Y, Li Y, Wu X, Edwards BF, Martin PD, Cygler M.
    Proteins; 1993 Nov 07; 17(3):252-65. PubMed ID: 8272424
    [Abstract] [Full Text] [Related]

  • 14. Design and characterization of hirulogs: a novel class of bivalent peptide inhibitors of thrombin.
    Maraganore JM, Bourdon P, Jablonski J, Ramachandran KL, Fenton JW.
    Biochemistry; 1990 Jul 31; 29(30):7095-101. PubMed ID: 2223763
    [Abstract] [Full Text] [Related]

  • 15. Rational design of hirulog-type inhibitors of thrombin.
    Egner U, Hoyer GA, Schleuning WD.
    J Comput Aided Mol Des; 1994 Oct 31; 8(5):479-90. PubMed ID: 7876896
    [Abstract] [Full Text] [Related]

  • 16. Design and evaluation of novel bivalent thrombin inhibitors based on amidinophenylalanines.
    Steinmetzer T, Renatus M, Künzel S, Eichinger A, Bode W, Wikström P, Hauptmann J, Stürzebecher J.
    Eur J Biochem; 1999 Oct 31; 265(2):598-605. PubMed ID: 10504391
    [Abstract] [Full Text] [Related]

  • 17. Conformationally restricted thrombin inhibitors resistant to proteolytic digestion.
    Szewczuk Z, Gibbs BF, Yue SY, Purisima EO, Konishi Y.
    Biochemistry; 1992 Sep 29; 31(38):9132-40. PubMed ID: 1390700
    [Abstract] [Full Text] [Related]

  • 18. Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human alpha-thrombin.
    Féthière J, Tsuda Y, Coulombe R, Konishi Y, Cygler M.
    Protein Sci; 1996 Jun 29; 5(6):1174-83. PubMed ID: 8762149
    [Abstract] [Full Text] [Related]

  • 19. A strong thrombin-inhibitory prourokinase derivative with sequence elements from hirudin and the human thrombin receptor.
    Wnendt S, Janocha E, Steffens GJ, Strassburger W.
    Protein Eng; 1997 Feb 29; 10(2):169-73. PubMed ID: 9089816
    [Abstract] [Full Text] [Related]

  • 20. Hirunorms are true hirudin mimetics. The crystal structure of human alpha-thrombin-hirunorm V complex.
    De Simone G, Lombardi A, Galdiero S, Nastri F, Della Morte R, Staiano N, Pedone C, Bolognesi M, Pavone V.
    Protein Sci; 1998 Feb 29; 7(2):243-53. PubMed ID: 9521099
    [Abstract] [Full Text] [Related]

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