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Journal Abstract Search

95 related items for PubMed ID: 8461303

  • 21. Potent bivalent thrombin inhibitors: replacement of the scissile peptide bond at P(1)-P(1)' with arginyl ketomethylene isosteres.
    Steinmetzer T, Zhu BY, Konishi Y.
    J Med Chem; 1999 Aug 12; 42(16):3109-15. PubMed ID: 10447955
    [Abstract] [Full Text] [Related]

  • 22. Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors.
    Qiu X, Padmanabhan KP, Carperos VE, Tulinsky A, Kline T, Maraganore JM, Fenton JW.
    Biochemistry; 1992 Dec 01; 31(47):11689-97. PubMed ID: 1445905
    [Abstract] [Full Text] [Related]

  • 23. In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
    Costanzo MJ, Almond HR, Hecker LR, Schott MR, Yabut SC, Zhang HC, Andrade-Gordon P, Corcoran TW, Giardino EC, Kauffman JA, Lewis JM, de Garavilla L, Haertlein BJ, Maryanoff BE.
    J Med Chem; 2005 Mar 24; 48(6):1984-2008. PubMed ID: 15771442
    [Abstract] [Full Text] [Related]

  • 24. Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A.
    Maryanoff BE, Qiu X, Padmanabhan KP, Tulinsky A, Almond HR, Andrade-Gordon P, Greco MN, Kauffman JA, Nicolaou KC, Liu A.
    Proc Natl Acad Sci U S A; 1993 Sep 01; 90(17):8048-52. PubMed ID: 8367461
    [Abstract] [Full Text] [Related]

  • 25. Crystal structure of a peptidyl pyridinium methyl ketone inhibitor with thrombin.
    Rehse PH, Steinmetzer T, Li Y, Konishi Y, Cygler M.
    Biochemistry; 1995 Sep 12; 34(36):11537-44. PubMed ID: 7547884
    [Abstract] [Full Text] [Related]

  • 26. The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin.
    Vijayalakshmi J, Padmanabhan KP, Mann KG, Tulinsky A.
    Protein Sci; 1994 Dec 12; 3(12):2254-71. PubMed ID: 7756983
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  • 29. The crystal structure of human alpha-thrombin complexed with LY178550, a nonpeptidyl, active site-directed inhibitor.
    Chirgadze NY, Sall DJ, Klimkowski VJ, Clawson DK, Briggs SL, Hermann R, Smith GF, Gifford-Moore DS, Wery JP.
    Protein Sci; 1997 Jul 12; 6(7):1412-7. PubMed ID: 9232642
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  • 30. Structure-function and refolding studies of the thrombin-specific inhibitor hirudin.
    Johnson PH, Sze P, Winant RC, Hudson D, Underhill P, Lazar JB, Olsen C, Almquist R.
    Haemostasis; 1991 Jul 12; 21 Suppl 1():41-8. PubMed ID: 1894196
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  • 32. Comparison of the structures of the cyclotheonamide A complexes of human alpha-thrombin and bovine beta-trypsin.
    Ganesh V, Lee AY, Clardy J, Tulinsky A.
    Protein Sci; 1996 May 12; 5(5):825-35. PubMed ID: 8732754
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  • 33. Rational design and selection of bivalent peptide ligands of thrombin incorporating P4-P1 tetrapeptide sequences: from good substrates to potent inhibitors.
    Su Z, Vinogradova A, Koutychenko A, Tolkatchev D, Ni F.
    Protein Eng Des Sel; 2004 Aug 12; 17(8):647-57. PubMed ID: 15358856
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  • 34. Amide and alpha-keto carbonyl inhibitors of thrombin based on arginine and lysine: synthesis, stability and biological characterization.
    Brady SF, Sisko JT, Stauffer KJ, Colton CD, Qiu H, Lewis SD, Ng AS, Shafer JA, Bogusky MJ, Veber DF.
    Bioorg Med Chem; 1995 Aug 12; 3(8):1063-78. PubMed ID: 7582980
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  • 35. The methyl group of N(alpha)(Me)Arg-containing peptides disturbs the active-site geometry of thrombin, impairing efficient cleavage.
    Friedrich R, Steinmetzer T, Huber R, Stürzebecher J, Bode W.
    J Mol Biol; 2002 Mar 01; 316(4):869-74. PubMed ID: 11884127
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  • 36. Rational design of true hirudin mimetics: synthesis and characterization of multisite-directed alpha-thrombin inhibitors.
    Lombardi A, Nastri F, Della Morte R, Rossi A, De Rosa A, Staiano N, Pedone C, Pavone V.
    J Med Chem; 1996 May 10; 39(10):2008-17. PubMed ID: 8642559
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  • 37. Structure-activity relationships of recombinant hirudins.
    Stürzebecher J, Walsmann P.
    Semin Thromb Hemost; 1991 Apr 10; 17(2):94-8. PubMed ID: 1771418
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  • 38. Amino acid sequence and structure modeling of savignin, a thrombin inhibitor from the tick, Ornithodoros savignyi.
    Mans BJ, Louw AI, Neitz AW.
    Insect Biochem Mol Biol; 2002 Jul 10; 32(7):821-8. PubMed ID: 12044499
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  • 39. A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
    Katz BA, Elrod K, Luong C, Rice MJ, Mackman RL, Sprengeler PA, Spencer J, Hataye J, Janc J, Link J, Litvak J, Rai R, Rice K, Sideris S, Verner E, Young W.
    J Mol Biol; 2001 Apr 13; 307(5):1451-86. PubMed ID: 11292354
    [Abstract] [Full Text] [Related]

  • 40. Designed inhibitors with hetero linkers for gastric proton pump H+,K+-ATPase: Steered molecular dynamics and metadynamics studies.
    Jana K, Bandyopadhyay T, Ganguly B.
    J Mol Graph Model; 2017 Nov 13; 78():129-138. PubMed ID: 29055186
    [Abstract] [Full Text] [Related]

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