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Journal Abstract Search

311 related items for PubMed ID: 8484736

  • 1. Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.
    Iwasaki M, Lindberg RL, Juvonen RO, Negishi M.
    Biochem J; 1993 Apr 15; 291 ( Pt 2)(Pt 2):569-73. PubMed ID: 8484736
    [Abstract] [Full Text] [Related]

  • 2. Engineering mouse P450coh to a novel corticosterone 15 alpha-hydroxylase and modeling steroid-binding orientation in the substrate pocket.
    Iwasaki M, Darden TA, Pedersen LG, Davis DG, Juvonen RO, Sueyoshi T, Negishi M.
    J Biol Chem; 1993 Jan 15; 268(2):759-62. PubMed ID: 8419350
    [Abstract] [Full Text] [Related]

  • 3. Role of residues 363 and 206 in conversion of cytochrome P450 2B1 from a steroid 16-hydroxylase to a 15 alpha-hydroxylase.
    Luo Z, He YA, Halpert JR.
    Arch Biochem Biophys; 1994 Feb 15; 309(1):52-7. PubMed ID: 8117113
    [Abstract] [Full Text] [Related]

  • 4. Altering the regiospecificity of androstenedione hydroxylase activity in P450s 2a-4/5 by a mutation of the residue at position 481.
    Iwasaki M, Darden TA, Pedersen LG, Negishi M.
    Biochemistry; 1995 Apr 18; 34(15):5054-9. PubMed ID: 7711025
    [Abstract] [Full Text] [Related]

  • 5. Role of residue 480 in substrate specificity of cytochrome P450 2B5 and 2B11.
    Liu J, He YA, Halpert JR.
    Arch Biochem Biophys; 1996 Mar 01; 327(1):167-73. PubMed ID: 8615687
    [Abstract] [Full Text] [Related]

  • 6. Point mutations at threonine-301 modify substrate specificity of rabbit liver microsomal cytochromes P-450 (laurate (omega-1)-hydroxylase and testosterone 16 alpha-hydroxylase).
    Imai Y, Nakamura M.
    Biochem Biophys Res Commun; 1989 Feb 15; 158(3):717-22. PubMed ID: 2493247
    [Abstract] [Full Text] [Related]

  • 7. Hydrophobic side chain requirements for lauric acid and progesterone hydroxylation at amino acid 113 in cytochrome P450 2C2, a potential determinant of substrate specificity.
    Straub P, Johnson EF, Kemper B.
    Arch Biochem Biophys; 1993 Nov 01; 306(2):521-7. PubMed ID: 8215458
    [Abstract] [Full Text] [Related]

  • 8. Alterations of the regiospecificity of progesterone metabolism by the mutagenesis of two key amino acid residues in rabbit cytochrome P450 2C3v.
    Richardson TH, Johnson EF.
    J Biol Chem; 1994 Sep 30; 269(39):23937-43. PubMed ID: 7929041
    [Abstract] [Full Text] [Related]

  • 9. Alteration of the substrate specificity of mouse 2A P450s by the identity of residue-209: steroid-binding site and orientation.
    Negishi M, Iwasaki M, Juvonen RO, Aida K.
    J Steroid Biochem Mol Biol; 1992 Dec 30; 43(8):1031-6. PubMed ID: 22217847
    [Abstract] [Full Text] [Related]

  • 10. Engineering of cytochrome P450 2B1 specificity. Conversion of an androgen 16 beta-hydroxylase to a 15 alpha-hydroxylase.
    Halpert JR, He YA.
    J Biol Chem; 1993 Feb 25; 268(6):4453-7. PubMed ID: 8440727
    [Abstract] [Full Text] [Related]

  • 11. Elucidation of amino acid residues critical for unique activities of rabbit cytochrome P450 2B5 using hybrid enzymes and reciprocal site-directed mutagenesis with rabbit cytochrome P450 2B4.
    Szklarz GD, He YQ, Kedzie KM, Halpert JR, Burnett VL.
    Arch Biochem Biophys; 1996 Mar 15; 327(2):308-18. PubMed ID: 8619620
    [Abstract] [Full Text] [Related]

  • 12. Interconversion of the androstenedione hydroxylase specificities of cytochromes P450 2B4 and 2B5 upon simultaneous site-directed mutagenesis of four key substrate recognition residues.
    He YQ, Szklarz GD, Halpert JR.
    Arch Biochem Biophys; 1996 Nov 01; 335(1):152-60. PubMed ID: 8914846
    [Abstract] [Full Text] [Related]

  • 13. Identification of three key residues in substrate recognition site 5 of human cytochrome P450 3A4 by cassette and site-directed mutagenesis.
    He YA, He YQ, Szklarz GD, Halpert JR.
    Biochemistry; 1997 Jul 22; 36(29):8831-9. PubMed ID: 9220969
    [Abstract] [Full Text] [Related]

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  • 15. Site-directed mutagenesis of cytochrome P450s CYP2A1 and CYP2A2: influence of the distal helix on the kinetics of testosterone hydroxylation.
    Hanioka N, Gonzalez FJ, Lindberg NA, Liu G, Gelboin HV, Korzekwa KR.
    Biochemistry; 1992 Apr 07; 31(13):3364-70. PubMed ID: 1554718
    [Abstract] [Full Text] [Related]

  • 16. The lithocholic acid 6 beta-hydroxylase cytochrome P-450, CYP 3A10, is an active catalyst of steroid-hormone 6 beta-hydroxylation.
    Chang TK, Teixeira J, Gil G, Waxman DJ.
    Biochem J; 1993 Apr 15; 291 ( Pt 2)(Pt 2):429-33. PubMed ID: 8484723
    [Abstract] [Full Text] [Related]

  • 17. Structural determinants of cytochrome P450 2B1 specificity: evidence for five substrate recognition sites.
    He Y, Luo Z, Klekotka PA, Burnett VL, Halpert JR.
    Biochemistry; 1994 Apr 12; 33(14):4419-24. PubMed ID: 8155660
    [Abstract] [Full Text] [Related]

  • 18. Steroid 17 alpha-hydroxylase and 17,20-lyase activities of P450c17: contributions of serine106 and P450 reductase.
    Lin D, Black SM, Nagahama Y, Miller WL.
    Endocrinology; 1993 Jun 12; 132(6):2498-506. PubMed ID: 8504753
    [Abstract] [Full Text] [Related]

  • 19. Alteration of high and low spin equilibrium by a single mutation of amino acid 209 in mouse cytochromes P450.
    Iwasaki M, Juvonen R, Lindberg R, Negishi M.
    J Biol Chem; 1991 Feb 25; 266(6):3380-2. PubMed ID: 1995602
    [Abstract] [Full Text] [Related]

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