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Journal Abstract Search

218 related items for PubMed ID: 8504466

  • 1. Depletion of O6-methylguanine-DNA methyltransferase and potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea antitumor activity by O6-benzylguanine in vitro.
    Chen JM, Zhang YP, Moschel RC, Ikenaga M.
    Carcinogenesis; 1993 May; 14(5):1057-60. PubMed ID: 8504466
    [Abstract] [Full Text] [Related]

  • 2. Extended depletion of O6-methylguanine-DNA methyltransferase activity following O6-benzyl-2'-deoxyguanosine or O6-benzylguanine combined with streptozotocin treatment enhances 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity.
    Marathi UK, Dolan ME, Erickson LC.
    Cancer Res; 1994 Aug 15; 54(16):4371-5. PubMed ID: 8044784
    [Abstract] [Full Text] [Related]

  • 3. Modulation of O6-methylguanine-DNA methyltransferase-mediated 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea resistance by O6-benzylguanine in vitro and in vivo.
    Chen JM, Zhang YP, Sui JL, Moschel RC, Ikenaga M.
    Anticancer Res; 1993 Aug 15; 13(3):801-5. PubMed ID: 8317915
    [Abstract] [Full Text] [Related]

  • 4. Prolonged depletion of O6-methylguanine DNA methyltransferase activity following exposure to O6-benzylguanine with or without streptozotocin enhances 1,3-bis(2-chloroethyl)-1-nitrosourea sensitivity in vitro.
    Marathi UK, Kroes RA, Dolan ME, Erickson LC.
    Cancer Res; 1993 Sep 15; 53(18):4281-6. PubMed ID: 8364924
    [Abstract] [Full Text] [Related]

  • 5. O6-methylguanine-DNA methyltransferase (MGMT) transfectants of a 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-sensitive colon cancer cell line selectively repopulate heterogenous MGMT+/MGMT- xenografts after BCNU and O6-benzylguanine plus BCNU.
    Phillips WP, Willson JK, Markowitz SD, Zborowska E, Zaidi NH, Liu L, Gordon NH, Gerson SL.
    Cancer Res; 1997 Nov 01; 57(21):4817-23. PubMed ID: 9354444
    [Abstract] [Full Text] [Related]

  • 6. Point mutations in human O6-alkylguanine-DNA alkyltransferase prevent the sensitization by O6-benzylguanine to killing by N,N'-bis (2-chloroethyl)-N-nitrosourea.
    Loktionova NA, Pegg AE.
    Cancer Res; 1996 Apr 01; 56(7):1578-83. PubMed ID: 8603405
    [Abstract] [Full Text] [Related]

  • 7. Potentiation of BCNU antitumor efficacy by 9-substituted O6-benzylguanines. Effect of metabolism.
    Kokkinakis DM, Moschel RC, Pegg AE, Schold SC.
    Cancer Chemother Pharmacol; 2000 Apr 01; 45(1):69-77. PubMed ID: 10647505
    [Abstract] [Full Text] [Related]

  • 8. O6-methylguanine-DNA methyltransferase, O6-benzylguanine, and resistance to clinical alkylators in pediatric primary brain tumor cell lines.
    Bobola MS, Silber JR, Ellenbogen RG, Geyer JR, Blank A, Goff RD.
    Clin Cancer Res; 2005 Apr 01; 11(7):2747-55. PubMed ID: 15814657
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  • 10. Enhancement effect of O6-fluorobenzylguanines on chloroethylnitrosourea cytotoxicity in tumor cells.
    Mineura K, Fukuchi M, Kowada M, Hitomi K, Terashima I, Kohda K.
    Life Sci; 1996 Apr 01; 58(19):PL303-8. PubMed ID: 8632694
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  • 14. Effect of O6-benzylguanine on the response to 1,3-bis(2-chloroethyl)-1-nitrosourea in the Dunning R3327G model of prostatic cancer.
    Dolan ME, Pegg AE, Biser ND, Moschel RC, English HF.
    Cancer Chemother Pharmacol; 1993 Apr 01; 32(3):221-5. PubMed ID: 8500228
    [Abstract] [Full Text] [Related]

  • 15. Anti-neoplastic activity of sequenced administration of O6-benzylguanine, streptozotocin, and 1,3-bis(2-chloroethyl)-1-nitrosourea in vitro and in vivo.
    Marathi UK, Dolan ME, Erickson LC.
    Biochem Pharmacol; 1994 Nov 29; 48(11):2127-34. PubMed ID: 7802703
    [Abstract] [Full Text] [Related]

  • 16. Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU).
    Dolan ME, Pegg AE, Moschel RC, Grindey GB.
    Biochem Pharmacol; 1993 Jul 20; 46(2):285-90. PubMed ID: 8347150
    [Abstract] [Full Text] [Related]

  • 17. Differential inactivation of O6-methylguanine-DNA methyltransferase activity by O6-arylmethylguanines.
    Mineura K, Fukuchi M, Kowada M, Terashima I, Kohda K.
    Int J Cancer; 1995 Sep 27; 63(1):148-51. PubMed ID: 7558444
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  • 18. Effect of O6-benzylguanine on the sensitivity of human tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation.
    Mitchell RB, Moschel RC, Dolan ME.
    Cancer Res; 1992 Mar 01; 52(5):1171-5. PubMed ID: 1737376
    [Abstract] [Full Text] [Related]

  • 19. Differential sensitivity of human and mouse alkyltransferase to O6-benzylguanine using a transgenic model.
    Liu L, Lee K, Wasan E, Gerson SL.
    Cancer Res; 1996 Apr 15; 56(8):1880-5. PubMed ID: 8620508
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  • 20. Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase with O6-benzylguanine or O6-benzyl-2'-deoxyguanosine.
    Kokkinakis DM, Ahmed MM, Chendil D, Moschel RC, Pegg AE.
    Clin Cancer Res; 2003 Sep 01; 9(10 Pt 1):3801-7. PubMed ID: 14506174
    [Abstract] [Full Text] [Related]

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