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Journal Abstract Search

180 related items for PubMed ID: 8530497

  • 1. Novel tricyclic inhibitors of farnesyl protein transferase. Biochemical characterization and inhibition of Ras modification in transfected Cos cells.
    Bishop WR, Bond R, Petrin J, Wang L, Patton R, Doll R, Njoroge G, Catino J, Schwartz J, Windsor W.
    J Biol Chem; 1995 Dec 22; 270(51):30611-8. PubMed ID: 8530497
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  • 2. Effects of SCH 59228, an orally bioavailable farnesyl protein transferase inhibitor, on the growth of oncogene-transformed fibroblasts and a human colon carcinoma xenograft in nude mice.
    Liu M, Bryant MS, Chen J, Lee S, Yaremko B, Li Z, Dell J, Lipari P, Malkowski M, Prioli N, Rossman RR, Korfmacher WA, Nomeir AA, Lin CC, Mallams AK, Doll RJ, Catino JJ, Girijavallabhan VM, Kirschmeier P, Bishop WR.
    Cancer Chemother Pharmacol; 1999 Dec 22; 43(1):50-8. PubMed ID: 9923541
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  • 7. Posttranslational modification of Ha-ras p21 by farnesyl versus geranylgeranyl isoprenoids is determined by the COOH-terminal amino acid.
    Kinsella BT, Erdman RA, Maltese WA.
    Proc Natl Acad Sci U S A; 1991 Oct 15; 88(20):8934-8. PubMed ID: 1924354
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  • 9. Discovery of novel nonpeptide tricyclic inhibitors of Ras farnesyl protein transferase.
    Njoroge FG, Doll RJ, Vibulbhan B, Alvarez CS, Bishop WR, Petrin J, Kirschmeier P, Carruthers NI, Wong JK, Albanese MM, Piwinski JJ, Catino J, Girijavallabhan V, Ganguly AK.
    Bioorg Med Chem; 1997 Jan 15; 5(1):101-13. PubMed ID: 9043662
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  • 10. Inhibitors of farnesyl protein transferase and MEK1,2 induce apoptosis in fibroblasts transformed with farnesylated but not geranylgeranylated H-Ras.
    Brassard DL, English JM, Malkowski M, Kirschmeier P, Nagabhushan TL, Bishop WR.
    Exp Cell Res; 2002 Feb 15; 273(2):138-46. PubMed ID: 11822869
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  • 11. Structure-activity relationship of 3-substituted N-(pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene )- piperidine inhibitors of farnesyl-protein transferase: design and synthesis of in vivo active antitumor compounds.
    Njoroge FG, Vibulbhan B, Rane DF, Bishop WR, Petrin J, Patton R, Bryant MS, Chen KJ, Nomeir AA, Lin CC, Liu M, King I, Chen J, Lee S, Yaremko B, Dell J, Lipari P, Malkowski M, Li Z, Catino J, Doll RJ, Girijavallabhan V, Ganguly AK.
    J Med Chem; 1997 Dec 19; 40(26):4290-301. PubMed ID: 9435898
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  • 12. Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro.
    James GL, Goldstein JL, Brown MS.
    J Biol Chem; 1995 Mar 17; 270(11):6221-6. PubMed ID: 7890759
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  • 15. Phosphinyl acid-based bisubstrate analog inhibitors of Ras farnesyl protein transferase.
    Patel DV, Gordon EM, Schmidt RJ, Weller HN, Young MG, Zahler R, Barbacid M, Carboni JM, Gullo-Brown JL, Hunihan L.
    J Med Chem; 1995 Feb 03; 38(3):435-42. PubMed ID: 7853336
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  • 17. Inhibition of farnesyl protein transferase by monoterpene, curcumin derivatives and gallotannin.
    Chen X, Hasuma T, Yano Y, Yoshimata T, Morishima Y, Wang Y, Otani S.
    Anticancer Res; 1997 Feb 03; 17(4A):2555-64. PubMed ID: 9252680
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  • 18. Synthesis of isomeric 3-piperidinyl and 3-pyrrolidinyl benzo[5,6]cyclohepta[1,2-b]pyridines: sulfonamido derivatives as inhibitors of Ras prenylation.
    Kelly J, Wolin R, Connolly M, Afonso A, James L, Kirshmeier P, Bishop WR, McPhail AT.
    Bioorg Med Chem; 1998 Jun 03; 6(6):673-86. PubMed ID: 9681133
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  • 19. Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein.
    Cox AD, Hisaka MM, Buss JE, Der CJ.
    Mol Cell Biol; 1992 Jun 03; 12(6):2606-15. PubMed ID: 1375323
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  • 20. Polyisoprenylation of Ras in vitro by a farnesyl-protein transferase.
    Schaber MD, O'Hara MB, Garsky VM, Mosser SC, Bergstrom JD, Moores SL, Marshall MS, Friedman PA, Dixon RA, Gibbs JB.
    J Biol Chem; 1990 Sep 05; 265(25):14701-4. PubMed ID: 2203759
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