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Journal Abstract Search

278 related items for PubMed ID: 8547248

  • 1. Binding of the neurotoxin fasciculin 2 to the acetylcholinesterase peripheral site drastically reduces the association and dissociation rate constants for N-methylacridinium binding to the active site.
    Rosenberry TL, Rabl CR, Neumann E.
    Biochemistry; 1996 Jan 23; 35(3):685-90. PubMed ID: 8547248
    [Abstract] [Full Text] [Related]

  • 2. Substrate binding to the peripheral site of acetylcholinesterase initiates enzymatic catalysis. Substrate inhibition arises as a secondary effect.
    Szegletes T, Mallender WD, Thomas PJ, Rosenberry TL.
    Biochemistry; 1999 Jan 05; 38(1):122-33. PubMed ID: 9890890
    [Abstract] [Full Text] [Related]

  • 3. Fasciculin 2 binds to the peripheral site on acetylcholinesterase and inhibits substrate hydrolysis by slowing a step involving proton transfer during enzyme acylation.
    Eastman J, Wilson EJ, Cerveñansky C, Rosenberry TL.
    J Biol Chem; 1995 Aug 25; 270(34):19694-701. PubMed ID: 7649979
    [Abstract] [Full Text] [Related]

  • 4. Nonequilibrium analysis alters the mechanistic interpretation of inhibition of acetylcholinesterase by peripheral site ligands.
    Szegletes T, Mallender WD, Rosenberry TL.
    Biochemistry; 1998 Mar 24; 37(12):4206-16. PubMed ID: 9521743
    [Abstract] [Full Text] [Related]

  • 5. Unmasking tandem site interaction in human acetylcholinesterase. Substrate activation with a cationic acetanilide substrate.
    Johnson JL, Cusack B, Davies MP, Fauq A, Rosenberry TL.
    Biochemistry; 2003 May 13; 42(18):5438-52. PubMed ID: 12731886
    [Abstract] [Full Text] [Related]

  • 6. [The fasciculin-acetylcholinesterase interaction].
    Marchot P.
    J Soc Biol; 1999 May 13; 193(6):505-8. PubMed ID: 10783708
    [Abstract] [Full Text] [Related]

  • 7. A steric blockade model for inhibition of acetylcholinesterase by peripheral site ligands and substrate.
    Rosenberry TL, Mallender WD, Thomas PJ, Szegletes T.
    Chem Biol Interact; 1999 May 14; 119-120():85-97. PubMed ID: 10421442
    [Abstract] [Full Text] [Related]

  • 8. Acetylthiocholine binds to asp74 at the peripheral site of human acetylcholinesterase as the first step in the catalytic pathway.
    Mallender WD, Szegletes T, Rosenberry TL.
    Biochemistry; 2000 Jul 04; 39(26):7753-63. PubMed ID: 10869180
    [Abstract] [Full Text] [Related]

  • 9. Allosteric control of acetylcholinesterase catalysis by fasciculin.
    Radić Z, Quinn DM, Vellom DC, Camp S, Taylor P.
    J Biol Chem; 1995 Sep 01; 270(35):20391-9. PubMed ID: 7657613
    [Abstract] [Full Text] [Related]

  • 10. Organophosphorylation of acetylcholinesterase in the presence of peripheral site ligands. Distinct effects of propidium and fasciculin.
    Mallender WD, Szegletes T, Rosenberry TL.
    J Biol Chem; 1999 Mar 26; 274(13):8491-9. PubMed ID: 10085081
    [Abstract] [Full Text] [Related]

  • 11. Conformers of acetylcholinesterase: a mechanism of allosteric control.
    Taylor JL, Mayer RT, Himel CM.
    Mol Pharmacol; 1994 Jan 26; 45(1):74-83. PubMed ID: 8302283
    [Abstract] [Full Text] [Related]

  • 12. Acetylcholinesterase: enhanced fluctuations and alternative routes to the active site in the complex with fasciculin-2.
    Bui JM, Tai K, McCammon JA.
    J Am Chem Soc; 2004 Jun 16; 126(23):7198-205. PubMed ID: 15186156
    [Abstract] [Full Text] [Related]

  • 13. Electrostatic influence on the kinetics of ligand binding to acetylcholinesterase. Distinctions between active center ligands and fasciculin.
    Radić Z, Kirchhoff PD, Quinn DM, McCammon JA, Taylor P.
    J Biol Chem; 1997 Sep 12; 272(37):23265-77. PubMed ID: 9287336
    [Abstract] [Full Text] [Related]

  • 14. Allosteric control of acetylcholinesterase activity by monoclonal antibodies.
    Saxena A, Hur R, Doctor BP.
    Biochemistry; 1998 Jan 06; 37(1):145-54. PubMed ID: 9425034
    [Abstract] [Full Text] [Related]

  • 15. Mechanism of acetylcholinesterase inhibition by fasciculin: a 5-ns molecular dynamics simulation.
    Tai K, Shen T, Henchman RH, Bourne Y, Marchot P, McCammon JA.
    J Am Chem Soc; 2002 May 29; 124(21):6153-61. PubMed ID: 12022850
    [Abstract] [Full Text] [Related]

  • 16. Interaction kinetics of reversible inhibitors and substrates with acetylcholinesterase and its fasciculin 2 complex.
    Radić Z, Taylor P.
    J Biol Chem; 2001 Feb 16; 276(7):4622-33. PubMed ID: 11036076
    [Abstract] [Full Text] [Related]

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  • 18. Site of fasciculin interaction with acetylcholinesterase.
    Radić Z, Duran R, Vellom DC, Li Y, Cervenansky C, Taylor P.
    J Biol Chem; 1994 Apr 15; 269(15):11233-9. PubMed ID: 8157652
    [Abstract] [Full Text] [Related]

  • 19. Binding of 125I-fasciculin to rat brain acetylcholinesterase. The complex still binds diisopropyl fluorophosphate.
    Marchot P, Khélif A, Ji YH, Mansuelle P, Bougis PE.
    J Biol Chem; 1993 Jun 15; 268(17):12458-67. PubMed ID: 8509385
    [Abstract] [Full Text] [Related]

  • 20. Crystal structure of an acetylcholinesterase-fasciculin complex: interaction of a three-fingered toxin from snake venom with its target.
    Harel M, Kleywegt GJ, Ravelli RB, Silman I, Sussman JL.
    Structure; 1995 Dec 15; 3(12):1355-66. PubMed ID: 8747462
    [Abstract] [Full Text] [Related]

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