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190 related items for PubMed ID: 8552660

  • 1. Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductase.
    Belcourt MF, Hodnick WF, Rockwell S, Sartorelli AC.
    Proc Natl Acad Sci U S A; 1996 Jan 09; 93(1):456-60. PubMed ID: 8552660
    [Abstract] [Full Text] [Related]

  • 2. Exploring the mechanistic aspects of mitomycin antibiotic bioactivation in Chinese hamster ovary cells overexpressing NADPH:cytochrome C (P-450) reductase and DT-diaphorase.
    Belcourt MF, Hodnick WF, Rockwell S, Sartorelli AC.
    Adv Enzyme Regul; 1998 Jan 09; 38():111-33. PubMed ID: 9762350
    [Abstract] [Full Text] [Related]

  • 3. Cytotoxicity and DNA lesions produced by mitomycin C and porfiromycin in hypoxic and aerobic EMT6 and Chinese hamster ovary cells.
    Fracasso PM, Sartorelli AC.
    Cancer Res; 1986 Aug 09; 46(8):3939-44. PubMed ID: 3089583
    [Abstract] [Full Text] [Related]

  • 4. Decreased NADPH:cytochrome P-450 reductase activity and impaired drug activation in a mammalian cell line resistant to mitomycin C under aerobic but not hypoxic conditions.
    Hoban PR, Walton MI, Robson CN, Godden J, Stratford IJ, Workman P, Harris AL, Hickson ID.
    Cancer Res; 1990 Aug 01; 50(15):4692-7. PubMed ID: 2114946
    [Abstract] [Full Text] [Related]

  • 5. The intracellular location of NADH:cytochrome b5 reductase modulates the cytotoxicity of the mitomycins to Chinese hamster ovary cells.
    Belcourt MF, Hodnick WF, Rockwell S, Sartorelli AC.
    J Biol Chem; 1998 Apr 10; 273(15):8875-81. PubMed ID: 9535868
    [Abstract] [Full Text] [Related]

  • 6. Bioactivation of mitomycin antibiotics by aerobic and hypoxic Chinese hamster ovary cells overexpressing DT-diaphorase.
    Belcourt MF, Hodnick WF, Rockwell S, Sartorelli AC.
    Biochem Pharmacol; 1996 Jun 28; 51(12):1669-78. PubMed ID: 8687482
    [Abstract] [Full Text] [Related]

  • 7. Effect of deficiencies in DNA repair on the toxicity of mitomycin C and porfiromycin to CHO cells under aerobic and hypoxic conditions.
    Hughes CS, Irvin CG, Rockwell S.
    Cancer Commun; 1991 Feb 28; 3(2):29-35. PubMed ID: 1899798
    [Abstract] [Full Text] [Related]

  • 8. Activation of mitomycin C by NADPH:cytochrome P-450 reductase.
    Bligh HF, Bartoszek A, Robson CN, Hickson ID, Kasper CB, Beggs JD, Wolf CR.
    Cancer Res; 1990 Dec 15; 50(24):7789-92. PubMed ID: 2123741
    [Abstract] [Full Text] [Related]

  • 9. Nuclear localization of NADPH:cytochrome c (P450) reductase enhances the cytotoxicity of mitomycin C to Chinese hamster ovary cells.
    Seow HA, Belcourt MF, Penketh PG, Hodnick WF, Tomasz M, Rockwell S, Sartorelli AC.
    Mol Pharmacol; 2005 Feb 15; 67(2):417-23. PubMed ID: 15547247
    [Abstract] [Full Text] [Related]

  • 10. Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C1.
    Keyes SR, Fracasso PM, Heimbrook DC, Rockwell S, Sligar SG, Sartorelli AC.
    Cancer Res; 1984 Dec 15; 44(12 Pt 1):5638-43. PubMed ID: 6437671
    [Abstract] [Full Text] [Related]

  • 11. Modification of the metabolism and cytotoxicity of bioreductive alkylating agents by dicoumarol in aerobic and hypoxic murine tumor cells.
    Keyes SR, Rockwell S, Sartorelli AC.
    Cancer Res; 1989 Jun 15; 49(12):3310-3. PubMed ID: 2470504
    [Abstract] [Full Text] [Related]

  • 12. Chemotherapeutic attack of hypoxic tumor cells by the bioreductive alkylating agent mitomycin C.
    Keyes SR, Heimbrook DC, Fracasso PM, Rockwell S, Sligar SG, Sartorelli AC.
    Adv Enzyme Regul; 1985 Jun 15; 23():291-307. PubMed ID: 3934922
    [Abstract] [Full Text] [Related]

  • 13. Reversal of mitomycin C resistance by overexpression of bioreductive enzymes in Chinese hamster ovary cells.
    Baumann RP, Hodnick WF, Seow HA, Belcourt MF, Rockwell S, Sherman DH, Sartorelli AC.
    Cancer Res; 2001 Nov 01; 61(21):7770-6. PubMed ID: 11691791
    [Abstract] [Full Text] [Related]

  • 14. Nuclear overexpression of NAD(P)H:quinone oxidoreductase 1 in Chinese hamster ovary cells increases the cytotoxicity of mitomycin C under aerobic and hypoxic conditions.
    Seow HA, Penketh PG, Belcourt MF, Tomasz M, Rockwell S, Sartorelli AC.
    J Biol Chem; 2004 Jul 23; 279(30):31606-12. PubMed ID: 15155746
    [Abstract] [Full Text] [Related]

  • 15. Oxygen and exposure kinetics as factors influencing the cytotoxicity of porfiromycin, a mitomycin C analogue, in Chinese hamster ovary cells.
    Marshall RS, Rauth AM.
    Cancer Res; 1988 Oct 15; 48(20):5655-9. PubMed ID: 3167822
    [Abstract] [Full Text] [Related]

  • 16. Mitomycin resistance in mammalian cells expressing the bacterial mitomycin C resistance protein MCRA.
    Belcourt MF, Penketh PG, Hodnick WF, Johnson DA, Sherman DH, Rockwell S, Sartorelli AC.
    Proc Natl Acad Sci U S A; 1999 Aug 31; 96(18):10489-94. PubMed ID: 10468636
    [Abstract] [Full Text] [Related]

  • 17. One-electron reduction of mitomycin c by rat liver: role of cytochrome P-450 and NADPH-cytochrome P-450 reductase.
    Vromans RM, van de Straat R, Groeneveld M, Vermeulen NP.
    Xenobiotica; 1990 Sep 31; 20(9):967-78. PubMed ID: 2122607
    [Abstract] [Full Text] [Related]

  • 18. Effect of pH on DNA alkylation by enzyme-activated mitomycin C and porfiromycin.
    Yu F, Pan SS.
    Mol Pharmacol; 1993 Jun 31; 43(6):863-9. PubMed ID: 8391116
    [Abstract] [Full Text] [Related]

  • 19. Distinct roles of cytochrome P450 reductase in mitomycin C redox cycling and cytotoxicity.
    Wang Y, Gray JP, Mishin V, Heck DE, Laskin DL, Laskin JD.
    Mol Cancer Ther; 2010 Jun 31; 9(6):1852-63. PubMed ID: 20501808
    [Abstract] [Full Text] [Related]

  • 20. Reductive activation of mitomycin C by NADH:cytochrome b5 reductase.
    Hodnick WF, Sartorelli AC.
    Cancer Res; 1993 Oct 15; 53(20):4907-12. PubMed ID: 8402680
    [Abstract] [Full Text] [Related]

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