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Journal Abstract Search

256 related items for PubMed ID: 8568811

  • 21. Amino acid residues that define both the isoprenoid and CAAX preferences of the Saccharomyces cerevisiae protein farnesyltransferase. Creating the perfect farnesyltransferase.
    Caplin BE, Ohya Y, Marshall MS.
    J Biol Chem; 1998 Apr 17; 273(16):9472-9. PubMed ID: 9545274
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  • 22. Discovery and structure-activity relationships of novel piperidine inhibitors of farnesyltransferase.
    Nara S, Tanaka R, Eishima J, Hara M, Takahashi Y, Otaki S, Foglesong RJ, Hughes PF, Turkington S, Kanda Y.
    J Med Chem; 2003 Jun 05; 46(12):2467-73. PubMed ID: 12773050
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  • 27. Inhibition of farnesyl protein transferase by monoterpene, curcumin derivatives and gallotannin.
    Chen X, Hasuma T, Yano Y, Yoshimata T, Morishima Y, Wang Y, Otani S.
    Anticancer Res; 1997 Jun 05; 17(4A):2555-64. PubMed ID: 9252680
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  • 28. Design, synthesis, and evaluation of potent and selective benzoyleneurea-based inhibitors of protein geranylgeranyltransferase-I.
    Carrico D, Blaskovich MA, Bucher CJ, Sebti SM, Hamilton AD.
    Bioorg Med Chem; 2005 Feb 01; 13(3):677-88. PubMed ID: 15653335
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  • 29. Protection against malignant conversion in SENCAR mouse skin by all trans retinoic acid: inhibition of the ras p21-processing enzyme farnesyltransferase and Ha-ras p21 membrane localization.
    Agarwal R, Mohan RR, Ahmad N, Mukhtar H.
    Mol Carcinog; 1996 Sep 01; 17(1):13-22. PubMed ID: 8876671
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  • 30. Probing the hydrophobic pocket of farnesyltransferase: aromatic substitution of CAAX peptidomimetics leads to highly potent inhibitors.
    Qian Y, Marugan JJ, Fossum RD, Vogt A, Sebti SM, Hamilton AD.
    Bioorg Med Chem; 1999 Dec 01; 7(12):3011-24. PubMed ID: 10658608
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  • 31. Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies.
    Sebti SM, Hamilton AD.
    Oncogene; 2000 Dec 27; 19(56):6584-93. PubMed ID: 11426643
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  • 33. Inhibitors of farnesyltransferase and Ras processing peptidase.
    Hall CC, Watkins JD, Ferguson SB, Foley LH, Georgopapadakou NH.
    Biochem Biophys Res Commun; 1995 Dec 26; 217(3):728-32. PubMed ID: 8554591
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  • 35. Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase.
    Wang GT, Wang X, Wang W, Hasvold LA, Sullivan G, Hutchins CW, O'Conner S, Gentiles R, Sowin T, Cohen J, Gu WZ, Zhang H, Rosenberg SH, Sham HL.
    Bioorg Med Chem Lett; 2005 Jan 03; 15(1):153-8. PubMed ID: 15582430
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  • 36. Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes.
    Lerner EC, Qian Y, Blaskovich MA, Fossum RD, Vogt A, Sun J, Cox AD, Der CJ, Hamilton AD, Sebti SM.
    J Biol Chem; 1995 Nov 10; 270(45):26802-6. PubMed ID: 7592920
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  • 37. N-Arylalkyl pseudopeptide inhibitors of farnesyltransferase.
    deSolms SJ, Giuliani EA, Graham SL, Koblan KS, Kohl NE, Mosser SD, Oliff AI, Pompliano DL, Rands E, Scholz TH, Wiscount CM, Gibbs JB, Smith RL.
    J Med Chem; 1998 Jul 02; 41(14):2651-6. PubMed ID: 9651171
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  • 38. 2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase.
    Williams TM, Ciccarone TM, MacTough SC, Bock RL, Conner MW, Davide JP, Hamilton K, Koblan KS, Kohl NE, Kral AM, Mosser SD, Omer CA, Pompliano DL, Rands E, Schaber MD, Shah D, Wilson FR, Gibbs JB, Graham SL, Hartman GD, Oliff AI, Smith RL.
    J Med Chem; 1996 Mar 29; 39(7):1345-8. PubMed ID: 8691462
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  • 39. Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor.
    Lerner EC, Qian Y, Hamilton AD, Sebti SM.
    J Biol Chem; 1995 Nov 10; 270(45):26770-3. PubMed ID: 7592913
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  • 40. NMR studies of novel inhibitors bound to farnesyl-protein transferase.
    Koblan KS, Culberson JC, Desolms SJ, Giuliani EA, Mosser SD, Omer CA, Pitzenberger SM, Bogusky MJ.
    Protein Sci; 1995 Apr 10; 4(4):681-8. PubMed ID: 7613466
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