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Journal Abstract Search

318 related items for PubMed ID: 8568814

  • 1. Dibenzoxepinone hydroxylamines and hydroxamic acids: dual inhibitors of cyclooxygenase and 5-lipoxygenase with potent topical antiinflammatory activity.
    Hamer RR, Tegeler JJ, Kurtz ES, Allen RC, Bailey SC, Elliott ME, Hellyer L, Helsley GC, Przekop P, Freed BS, White J, Martin LL.
    J Med Chem; 1996 Jan 05; 39(1):246-52. PubMed ID: 8568814
    [Abstract] [Full Text] [Related]

  • 2. Tepoxalin: a dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile.
    Argentieri DC, Ritchie DM, Ferro MP, Kirchner T, Wachter MP, Anderson DW, Rosenthale ME, Capetola RJ.
    J Pharmacol Exp Ther; 1994 Dec 05; 271(3):1399-408. PubMed ID: 7996452
    [Abstract] [Full Text] [Related]

  • 3. Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors.
    Kolasa T, Brooks CD, Rodriques KE, Summers JB, Dellaria JF, Hulkower KI, Bouska J, Bell RL, Carter GW.
    J Med Chem; 1997 Feb 28; 40(5):819-24. PubMed ID: 9057869
    [Abstract] [Full Text] [Related]

  • 4. Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
    Chowdhury MA, Abdellatif KR, Dong Y, Das D, Suresh MR, Knaus EE.
    Bioorg Med Chem Lett; 2008 Dec 01; 18(23):6138-41. PubMed ID: 18945614
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases.
    Rao PN, Chen QH, Knaus EE.
    J Med Chem; 2006 Mar 09; 49(5):1668-83. PubMed ID: 16509583
    [Abstract] [Full Text] [Related]

  • 6. Computer-aided discovery of anti-inflammatory thiazolidinones with dual cyclooxygenase/lipoxygenase inhibition.
    Geronikaki AA, Lagunin AA, Hadjipavlou-Litina DI, Eleftheriou PT, Filimonov DA, Poroikov VV, Alam I, Saxena AK.
    J Med Chem; 2008 Mar 27; 51(6):1601-9. PubMed ID: 18311898
    [Abstract] [Full Text] [Related]

  • 7.
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  • 8. New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations at the 5 position.
    Janusz JM, Young PA, Ridgeway JM, Scherz MW, Enzweiler K, Wu LI, Gan L, Chen J, Kellstein DE, Green SA, Tulich JL, Rosario-Jansen T, Magrisso IJ, Wehmeyer KR, Kuhlenbeck DL, Eichhold TH, Dobson RL.
    J Med Chem; 1998 Aug 27; 41(18):3515-29. PubMed ID: 9719605
    [Abstract] [Full Text] [Related]

  • 9. Non-steroidal antiinflammatory agents. Synthesis and enzyme inhibition of 2-[4-(heteroarylmethyl)phenyl] propanoic acids and analogues.
    Silvestri R, Pagnozzi E, Valoti M, Fusi F.
    Farmaco; 1994 Oct 27; 49(10):625-32. PubMed ID: 7826468
    [Abstract] [Full Text] [Related]

  • 10. Design, synthesis, and biological evaluation of some novel indolizine derivatives as dual cyclooxygenase and lipoxygenase inhibitor for anti-inflammatory activity.
    Shrivastava SK, Srivastava P, Bandresh R, Tripathi PN, Tripathi A.
    Bioorg Med Chem; 2017 Aug 15; 25(16):4424-4432. PubMed ID: 28669741
    [Abstract] [Full Text] [Related]

  • 11. Synthesis and biological evaluation of O-methyl and O-ethyl NSAID hydroxamic acids.
    Rajić Z, Perković I, Butula I, Zorc B, Hadjipavlou-Litina D, Pontiki E, Pepeljnjak S, Kosalec I.
    J Enzyme Inhib Med Chem; 2009 Oct 15; 24(5):1179-87. PubMed ID: 19772490
    [Abstract] [Full Text] [Related]

  • 12. [2-Aryl-pyrrolo[2,1-b]benzothiazoles as a selective or dual inhibitors of cyclo-oxygenases and 5-lipoxygenases. 21. Non-steroidal anti-inflammatory agents].
    Dannhardt G, Kreher M, Nowe U, Schmitt S.
    Pharmazie; 1997 Jun 15; 52(6):428-36. PubMed ID: 9324689
    [Abstract] [Full Text] [Related]

  • 13. Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: dual inhibitors of cyclooxygenases and 5-lipoxygenase.
    Yu G, Praveen Rao PN, Chowdhury MA, Abdellatif KR, Dong Y, Das D, Velázquez CA, Suresh MR, Knaus EE.
    Bioorg Med Chem Lett; 2010 Apr 01; 20(7):2168-73. PubMed ID: 20202839
    [Abstract] [Full Text] [Related]

  • 14. Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase.
    Li Y, Chen SH, Ou TM, Tan JH, Li D, Gu LQ, Huang ZS.
    Bioorg Med Chem; 2011 Mar 15; 19(6):2074-83. PubMed ID: 21349729
    [Abstract] [Full Text] [Related]

  • 15. Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs).
    Chen QH, Rao PN, Knaus EE.
    Bioorg Med Chem; 2006 Dec 01; 14(23):7898-909. PubMed ID: 16904331
    [Abstract] [Full Text] [Related]

  • 16. Synthesis and biological evaluation of a new class of acyl derivatives of 3-amino-1-phenyl-4,5-dihydro-1H-pyrazol-5-one as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors.
    Cusan C, Spalluto G, Prato M, Adams M, Bodensieck A, Bauer R, Tubaro A, Bernardi P, Da Ros T.
    Farmaco; 2005 Apr 01; 60(4):327-32. PubMed ID: 15848208
    [Abstract] [Full Text] [Related]

  • 17. Phenylsulphonyl urenyl chalcone derivatives as dual inhibitors of cyclo-oxygenase-2 and 5-lipoxygenase.
    Araico A, Terencio MC, Alcaraz MJ, Domínguez JN, León C, Ferrándiz ML.
    Life Sci; 2006 May 15; 78(25):2911-8. PubMed ID: 16360707
    [Abstract] [Full Text] [Related]

  • 18. Adamantane derivatives of thiazolyl-N-substituted amide, as possible non-steroidal anti-inflammatory agents.
    Kouatly O, Geronikaki A, Kamoutsis C, Hadjipavlou-Litina D, Eleftheriou P.
    Eur J Med Chem; 2009 Mar 15; 44(3):1198-204. PubMed ID: 18603333
    [Abstract] [Full Text] [Related]

  • 19. Discovery of potential anti-inflammatory drugs: diaryl-1,2,4-triazoles bearing N-hydroxyurea moiety as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase.
    Jiang B, Huang X, Yao H, Jiang J, Wu X, Jiang S, Wang Q, Lu T, Xu J.
    Org Biomol Chem; 2014 Apr 07; 12(13):2114-27. PubMed ID: 24562695
    [Abstract] [Full Text] [Related]

  • 20. Discovery of 3-(4-bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide as a novel dual cyclooxygenase/5-lipoxygenase inhibitor that also inhibits tumor necrosis factor-alpha production.
    Chen CS, Tan CM, Huang CH, Chang LC, Wang JP, Cheng FC, Chern JW.
    Bioorg Med Chem; 2010 Jan 15; 18(2):597-604. PubMed ID: 20056549
    [Abstract] [Full Text] [Related]

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