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Journal Abstract Search

166 related items for PubMed ID: 8576277

  • 1. Cellular pharmacokinetics of ZD1694 in cultured human leukaemia cells sensitive, or made resistant, to this drug.
    Takemura Y, Gibson W, Kimbell R, Kobayashi H, Miyachi H, Jackman AL.
    J Cancer Res Clin Oncol; 1996; 122(2):109-17. PubMed ID: 8576277
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  • 4. Variable expression of RFC1 in human leukemia cell lines resistant to antifolates.
    Kobayashi H, Takemura Y, Ohnuma T.
    Cancer Lett; 1998 Feb 27; 124(2):135-42. PubMed ID: 9500202
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  • 6. The measurement of polyglutamate metabolites of the thymidylate synthase inhibitor, ICI D1694, in mouse and human cultured cells.
    Gibson W, Bisset GM, Marsham PR, Kelland LR, Judson IR, Jackman AL.
    Biochem Pharmacol; 1993 Feb 24; 45(4):863-9. PubMed ID: 7680860
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  • 8. Determinants of activity of the antifolate thymidylate synthase inhibitors Tomudex (ZD1694) and GW1843U89 against mono- and multilayered colon cancer cell lines under folate-restricted conditions.
    Peters GJ, Smitskamp-Wilms E, Smid K, Pinedo HM, Jansen G.
    Cancer Res; 1999 Nov 01; 59(21):5529-35. PubMed ID: 10554030
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  • 9. Mechanisms of resistance to N-[5-[N-(3,4-dihydro-2-methyl-4- oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcinoma cell line.
    Lu K, Yin MB, McGuire JJ, Bonmassar E, Rustum YM.
    Biochem Pharmacol; 1995 Jul 31; 50(3):391-8. PubMed ID: 7646540
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  • 10. Formation and retention and biological activity of N10-propargyl-5,8-dideazafolic acid (CB3717) polyglutamates in L1210 cells in vitro.
    Sikora E, Jackman AL, Newell DR, Calvert AH.
    Biochem Pharmacol; 1988 Nov 01; 37(21):4047-54. PubMed ID: 2461200
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  • 11. Recent advances in the study of rTS proteins. rTS expression during growth and in response to thymidylate synthase inhibitors in human tumor cells.
    Dolnick BJ, Lu K, Yin MB, Rustum YM.
    Adv Enzyme Regul; 1997 Nov 01; 37():95-109. PubMed ID: 9381988
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  • 12. [Separation of methotrexate-polyglutamates by capillary electrophoresis and its application to the measurement of gamma-glutamyl hydrolase activity in human leukemia cells in culture].
    Takemura Y, Kobayashi H, Sekiguchi S.
    Rinsho Byori; 1996 Jan 01; 44(1):51-6. PubMed ID: 8691640
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  • 13. Variable expression of the folylpolyglutamate synthetase gene at the level of mRNA transcription in human leukemia cell lines sensitive, or made resistant, to various antifolate drugs.
    Takemura Y, Kobayashi H, Miyachi H.
    Anticancer Drugs; 1999 Aug 01; 10(7):677-83. PubMed ID: 10507318
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  • 14. Thymidylate synthase as a target for growth inhibition in methotrexate-sensitive and -resistant human head and neck cancer and leukemia cell lines.
    McGuire JJ, Magee KJ, Russell CA, Canestrari JM.
    Oncol Res; 1997 Aug 01; 9(3):139-47. PubMed ID: 9220499
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  • 15. Ex vivo activity of methotrexate versus novel antifolate inhibitors of dihydrofolate reductase and thymidylate synthase against childhood leukemia cells.
    Mauritz R, Bekkenk MW, Rots MG, Pieters R, Mini E, van Zantwijk CH, Veerman AJ, Peters GJ, Jansen G.
    Clin Cancer Res; 1998 Oct 01; 4(10):2399-410. PubMed ID: 9796971
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  • 16. Immunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition; effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukaemia cells.
    Aherne GW, Hardcastle A, Raynaud F, Jackman AL.
    Biochem Pharmacol; 1996 May 17; 51(10):1293-301. PubMed ID: 8787544
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  • 17. Comparison of plasma and tissue levels of ZD1694 (Tomudex), a highly polyglutamatable quinazoline thymidylate synthase inhibitor, in preclinical models.
    Aherne GW, Ward E, Lawrence N, Dobinson D, Clarke SJ, Musgrove H, Sutcliffe F, Stephens T, Jackman AL.
    Br J Cancer; 1998 May 17; 77(2):221-6. PubMed ID: 9460992
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  • 18. Quinazoline thymidylate synthase inhibitors: methods for assessing the contribution of polyglutamation to their in vitro activity.
    Jackman AL, Kimbell R, Brown M, Brunton L, Boyle FT.
    Anticancer Drug Des; 1995 Oct 17; 10(7):555-72. PubMed ID: 7495479
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  • 19. Biological activity of the multitargeted antifolate, MTA (LY231514), in human cell lines with different resistance mechanisms to antifolate drugs.
    Schultz RM, Chen VJ, Bewley JR, Roberts EF, Shih C, Dempsey JA.
    Semin Oncol; 1999 Apr 17; 26(2 Suppl 6):68-73. PubMed ID: 10598558
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  • 20. ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.
    Jackman AL, Taylor GA, Gibson W, Kimbell R, Brown M, Calvert AH, Judson IR, Hughes LR.
    Cancer Res; 1991 Oct 15; 51(20):5579-86. PubMed ID: 1913676
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