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227 related items for PubMed ID: 8585857

  • 1. EMD 53998 acts as Ca(2+)-sensitizer and phosphodiesterase III-inhibitor in human myocardium.
    Uhlmann R, Schwinger RH, Lues I, Erdmann E.
    Basic Res Cardiol; 1995; 90(5):365-71. PubMed ID: 8585857
    [Abstract] [Full Text] [Related]

  • 2. The novel cardiotonic agent EMD 53 998 is a potent "calcium sensitizer".
    Beier N, Harting J, Jonas R, Klockow M, Lues I, Haeusler G.
    J Cardiovasc Pharmacol; 1991 Jul; 18(1):17-27. PubMed ID: 1719287
    [Abstract] [Full Text] [Related]

  • 3. Contribution of cAMP-phosphodiesterase inhibition and sensitization of the contractile proteins for calcium to the inotropic effect of pimobendan in the failing human myocardium.
    Böhm M, Morano I, Pieske B, Rüegg JC, Wankerl M, Zimmermann R, Erdmann E.
    Circ Res; 1991 Mar; 68(3):689-701. PubMed ID: 1660359
    [Abstract] [Full Text] [Related]

  • 4. Mechanism underlying the reduced positive inotropic effects of the phosphodiesterase III inhibitors pimobendan, adibendan and saterinone in failing as compared to nonfailing human cardiac muscle preparations.
    von der Leyen H, Mende U, Meyer W, Neumann J, Nose M, Schmitz W, Scholz H, Starbatty J, Stein B, Wenzlaff H.
    Naunyn Schmiedebergs Arch Pharmacol; 1991 Jul; 344(1):90-100. PubMed ID: 1723153
    [Abstract] [Full Text] [Related]

  • 5. The two mechanisms of action of racemic cardiotonic EMD 53998, calcium sensitization and phosphodiesterase inhibition, reside in different enantiomers.
    Lues I, Beier N, Jonas R, Klockow M, Haeusler G.
    J Cardiovasc Pharmacol; 1993 Jun; 21(6):883-92. PubMed ID: 7687712
    [Abstract] [Full Text] [Related]

  • 6. Increase in force of contraction by activation of the Na+/Ca(2+)-exchanger in human myocardium.
    Müller-Ehmsen J, Frank K, Brixius K, Schwinger RH.
    Br J Clin Pharmacol; 1997 Apr; 43(4):399-405. PubMed ID: 9146852
    [Abstract] [Full Text] [Related]

  • 7. Effects of the Ca2+ sensitizers EMD 57033 and CGP 48506 on myocardial contractility and Ca2+ transients in human ventricular and atrial myocardium.
    Brixius K, Reicke S, Reuter H, Schwinger RH.
    Z Kardiol; 2002 Apr; 91(4):312-8. PubMed ID: 12063703
    [Abstract] [Full Text] [Related]

  • 8. Ca2+ sensitization in idiopathic dilated human myocardium. Differential in vitro effects of (+)-(5-methyl-6-phenyl)-1,3,5,6-tetrahydro-3,6-methano-1,5-benzodiazoci ne-2,4-dione, a novel purely Ca2+sensitizing agent, and (+)-5-(1-(3,4-dimethoxybenzoyl)-1,2,3,4-tetrahydroquinolin-6-yl)-6-meth yl-3, 6-dihydro-2H-1,3,4-thiadiazin-2-one on skinned fibres and isolated ventricular strips.
    Herzig JW, Chiesi M, Depersin H, Grüninger S, Hasenfuss G, Kubalek R, Leutert T, Pieske B, Pioch K, Wenk P, Holubarsch C.
    Arzneimittelforschung; 1996 Jun; 46(6):586-93. PubMed ID: 8767348
    [Abstract] [Full Text] [Related]

  • 9. Ca++ sensitizers impair cardiac relaxation in failing human myocardium.
    Hajjar RJ, Schmidt U, Helm P, Gwathmey JK.
    J Pharmacol Exp Ther; 1997 Jan; 280(1):247-54. PubMed ID: 8996203
    [Abstract] [Full Text] [Related]

  • 10. Effects of calcium sensitizers on intracellular calcium handling and myocardial energetics.
    Hasenfuss G, Pieske B, Kretschmann B, Holubarsch C, Alpert NR, Just H.
    J Cardiovasc Pharmacol; 1995 Jan; 26 Suppl 1():S45-51. PubMed ID: 8907130
    [Abstract] [Full Text] [Related]

  • 11. New inotropic concepts: rationale for and differences between calcium sensitizers and phosphodiesterase inhibitors.
    Holubarsch C.
    Cardiology; 1997 Jan; 88 Suppl 2():12-20. PubMed ID: 9142431
    [Abstract] [Full Text] [Related]

  • 12. Troponin C-mediated calcium sensitization by levosimendan accelerates the proportional development of isometric tension.
    Haikala H, Levijoki J, Lindén IB.
    J Mol Cell Cardiol; 1995 Oct; 27(10):2155-65. PubMed ID: 8576932
    [Abstract] [Full Text] [Related]

  • 13. In vivo evidence of positive inotropism of EMD 57033 through calcium sensitization.
    Haeusler G, Jonas R, Minck KO, Schliep HJ, Schelling P, Weygandt H, Lues I.
    J Cardiovasc Pharmacol; 1997 May; 29(5):647-55. PubMed ID: 9213208
    [Abstract] [Full Text] [Related]

  • 14. Evidence for a sustained effectiveness of sodium-channel activators in failing human myocardium.
    Schwinger RH, Böhm M, Mittmann C, La Rosée K, Erdmann E.
    J Mol Cell Cardiol; 1991 Apr; 23(4):461-71. PubMed ID: 1658340
    [Abstract] [Full Text] [Related]

  • 15. Effects of levosimendan on myocardial contractility and Ca2+ transients in aequorin-loaded right-ventricular papillary muscles and indo-1-loaded single ventricular cardiomyocytes of the rabbit.
    Sato S, Talukder MA, Sugawara H, Sawada H, Endoh M.
    J Mol Cell Cardiol; 1998 Jun; 30(6):1115-28. PubMed ID: 9689586
    [Abstract] [Full Text] [Related]

  • 16. Stereoselectivity of actions of the calcium sensitizer [+]-EMD 60263 and its enantiomer [-]-EMD 60264.
    Ravens U, Flüss OM, Li Q, Himmel HM, Wettwer E, Klockow M, Lues I.
    Naunyn Schmiedebergs Arch Pharmacol; 1997 Jun; 355(6):733-42. PubMed ID: 9205958
    [Abstract] [Full Text] [Related]

  • 17. Effects of Ca2+ sensitizers on contraction, [Ca2+]i transient and myofilament Ca2+ sensitivity in diabetic rat myocardium: potential usefulness as inotropic agents.
    Ishitani T, Hattori Y, Sakuraya F, Onozuka H, Makino T, Matsuda N, Gando S, Kemmotsu O.
    J Pharmacol Exp Ther; 2001 Aug; 298(2):613-22. PubMed ID: 11454923
    [Abstract] [Full Text] [Related]

  • 18. Effect of inotropic interventions on the force-frequency relation in the human heart.
    Bavendiek U, Brixius K, Münch G, Zobel C, Müller-Ehmsen J, Schwinger RH.
    Basic Res Cardiol; 1998 Aug; 93 Suppl 1():76-85. PubMed ID: 9833134
    [Abstract] [Full Text] [Related]

  • 19. The effect of positive inotropes on the failing human myocardium.
    Erdmann E.
    Cardiology; 1997 Aug; 88 Suppl 2():7-11. PubMed ID: 9142430
    [Abstract] [Full Text] [Related]

  • 20. Cardiac Ca2+ signaling and Ca2+ sensitizers.
    Endoh M.
    Circ J; 2008 Dec; 72(12):1915-25. PubMed ID: 18981594
    [Abstract] [Full Text] [Related]

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