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225 related items for PubMed ID: 8592681

  • 1. Kinetic analysis of hepatobiliary transport for conjugated metabolites in the perfused liver of mutant rats (EHBR) with hereditary conjugated hyperbilirubinemia.
    Takenaka O, Horie T, Kobayashi K, Suzuki H, Sugiyama Y.
    Pharm Res; 1995 Nov; 12(11):1746-55. PubMed ID: 8592681
    [Abstract] [Full Text] [Related]

  • 2. Different biliary excretion systems for glucuronide and sulfate of a model compound; study using Eisai hyperbilirubinemic rats.
    Takenaka O, Horie T, Suzuki H, Sugiyama Y.
    J Pharmacol Exp Ther; 1995 Sep; 274(3):1362-9. PubMed ID: 7562509
    [Abstract] [Full Text] [Related]

  • 3. Kinetic analysis of the primary active transport of conjugated metabolites across the bile canalicular membrane: comparative study of S-(2,4-dinitrophenyl)-glutathione and 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole glucuronide.
    Niinuma K, Takenaka O, Horie T, Kobayashi K, Kato Y, Suzuki H, Sugiyama Y.
    J Pharmacol Exp Ther; 1997 Aug; 282(2):866-72. PubMed ID: 9262353
    [Abstract] [Full Text] [Related]

  • 4. Carrier-mediated active transport of the glucuronide and sulfate of 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole (E3040) into rat liver: quantitative comparison of permeability in isolated hepatocytes, perfused liver and liver in vivo.
    Takenaka O, Horie T, Suzuki H, Sugiyama Y.
    J Pharmacol Exp Ther; 1997 Feb; 280(2):948-58. PubMed ID: 9023311
    [Abstract] [Full Text] [Related]

  • 5. Temocaprilat, a novel angiotensin-converting enzyme inhibitor, is excreted in bile via an ATP-dependent active transporter (cMOAT) that is deficient in Eisai hyperbilirubinemic mutant rats (EHBR).
    Ishizuka H, Konno K, Naganuma H, Sasahara K, Kawahara Y, Niinuma K, Suzuki H, Sugiyama Y.
    J Pharmacol Exp Ther; 1997 Mar; 280(3):1304-11. PubMed ID: 9067317
    [Abstract] [Full Text] [Related]

  • 6. Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats.
    Chu XY, Kato Y, Niinuma K, Sudo KI, Hakusui H, Sugiyama Y.
    J Pharmacol Exp Ther; 1997 Apr; 281(1):304-14. PubMed ID: 9103511
    [Abstract] [Full Text] [Related]

  • 7. Primary active transport of organic anions on bile canalicular membrane in humans.
    Niinuma K, Kato Y, Suzuki H, Tyson CA, Weizer V, Dabbs JE, Froehlich R, Green CE, Sugiyama Y.
    Am J Physiol; 1999 May; 276(5):G1153-64. PubMed ID: 10330006
    [Abstract] [Full Text] [Related]

  • 8. Carrier-mediated mechanism for the biliary excretion of the quinolone antibiotic grepafloxacin and its glucuronide in rats.
    Sasabe H, Tsuji A, Sugiyama Y.
    J Pharmacol Exp Ther; 1998 Mar; 284(3):1033-9. PubMed ID: 9495864
    [Abstract] [Full Text] [Related]

  • 9. Mechanism of the tissue distribution and biliary excretion of the cyclic peptide octreotide.
    Yamada T, Niinuma K, Lemaire M, Terasaki T, Sugiyama Y.
    J Pharmacol Exp Ther; 1996 Dec; 279(3):1357-64. PubMed ID: 8968360
    [Abstract] [Full Text] [Related]

  • 10. Functional integrity of hepatocyte canalicular membrane transport of taurocholate and bilirubin diglucuronide in Eisai hyperbilirubinuria rats.
    Adachi Y, Kobayashi H, Shouji M, Kitano M, Okuyama Y, Yamamoto T.
    Life Sci; 1993 Dec; 52(9):777-84. PubMed ID: 8437507
    [Abstract] [Full Text] [Related]

  • 11. Treatment of hyperbilirubinemia in Eisai hyperbilirubinemic rat by transfecting human MRP2/ABCC2 gene.
    Hirouchi M, Suzuki H, Sugiyama Y.
    Pharm Res; 2005 Apr; 22(4):661-6. PubMed ID: 15846474
    [Abstract] [Full Text] [Related]

  • 12. Biliary excretion of glycyrrhizin in rats: kinetic basis for multiplicity in bile canalicular transport of organic anions.
    Shimamura H, Suzuki H, Tagaya O, Horie T, Sugiyama Y.
    Pharm Res; 1996 Dec; 13(12):1833-7. PubMed ID: 8987080
    [Abstract] [Full Text] [Related]

  • 13. Kinetic analysis of hepatobiliary transport of organic anions in Eisai hyperbilirubinemic mutant rats.
    Sathirakul K, Suzuki H, Yasuda K, Hanano M, Tagaya O, Horie T, Sugiyama Y.
    J Pharmacol Exp Ther; 1993 Jun; 265(3):1301-12. PubMed ID: 8510010
    [Abstract] [Full Text] [Related]

  • 14. Biliary excretion of 17beta-estradiol 17beta-D-glucuronide is predominantly mediated by cMOAT/MRP2.
    Morikawa A, Goto Y, Suzuki H, Hirohashi T, Sugiyama Y.
    Pharm Res; 2000 May; 17(5):546-52. PubMed ID: 10888306
    [Abstract] [Full Text] [Related]

  • 15. Biliary excretion of bile acid conjugates in a hyperbilirubinemic mutant Sprague-Dawley rat.
    Takikawa H, Sano N, Narita T, Uchida Y, Yamanaka M, Horie T, Mikami T, Tagaya O.
    Hepatology; 1991 Aug; 14(2):352-60. PubMed ID: 1860692
    [Abstract] [Full Text] [Related]

  • 16. Hepatic biliary transport after hepatocyte transplantation in Eizai hyperbilirubinemic rats.
    Hamaguchi H, Yamaguchi Y, Goto M, Misumi M, Hisama N, Miyanari N, Mori K, Ogawa M.
    Hepatology; 1994 Jul; 20(1 Pt 1):220-4. PubMed ID: 8020892
    [Abstract] [Full Text] [Related]

  • 17. Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump.
    Akita H, Suzuki H, Ito K, Kinoshita S, Sato N, Takikawa H, Sugiyama Y.
    Biochim Biophys Acta; 2001 Mar 09; 1511(1):7-16. PubMed ID: 11248200
    [Abstract] [Full Text] [Related]

  • 18. Both cMOAT/MRP2 and another unknown transporter(s) are responsible for the biliary excretion of glucuronide conjugate of the nonpeptide angiotensin II antagonist, telmisaltan.
    Nishino A, Kato Y, Igarashi T, Sugiyama Y.
    Drug Metab Dispos; 2000 Oct 09; 28(10):1146-8. PubMed ID: 10997931
    [Abstract] [Full Text] [Related]

  • 19. Primary active transport of pravastatin across the liver canalicular membrane in normal and mutant Eisai hyperbilirubinemic rats.
    Yamazaki M, Kobayashi K, Sugiyama Y.
    Biopharm Drug Dispos; 1996 Oct 09; 17(7):607-21. PubMed ID: 8894118
    [Abstract] [Full Text] [Related]

  • 20. Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats.
    Hirohashi T, Suzuki H, Ito K, Ogawa K, Kume K, Shimizu T, Sugiyama Y.
    Mol Pharmacol; 1998 Jun 09; 53(6):1068-75. PubMed ID: 9614210
    [Abstract] [Full Text] [Related]

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