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144 related items for PubMed ID: 8599613

  • 1. KN-62, a calcium/calmodulin-dependent protein kinase II inhibitor, inhibits high potassium-stimulated prolactin secretion and intracellular calcium increases in anterior pituitary cells.
    Cui ZJ, Hidaka H, Dannies PS.
    Biochim Biophys Acta; 1996 Feb 29; 1310(3):343-7. PubMed ID: 8599613
    [Abstract] [Full Text] [Related]

  • 2. Inhibition of voltage-gated Ca2+ channels and insulin secretion in HIT cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-62: comparison with antagonists of calmodulin and L-type Ca2+ channels.
    Li G, Hidaka H, Wollheim CB.
    Mol Pharmacol; 1992 Sep 29; 42(3):489-8. PubMed ID: 1328847
    [Abstract] [Full Text] [Related]

  • 3. Inhibition of voltage-gated Ca2+ channel activity in small cell lung carcinoma by the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperaz ine) .
    Williams CL, Porter RA, Phelps SH.
    Biochem Pharmacol; 1995 Dec 22; 50(12):1979-85. PubMed ID: 8849323
    [Abstract] [Full Text] [Related]

  • 4. Effects of protein kinase inhibitors on morphology and function of cultured bovine adrenal chromaffin cells: KN-62 inhibits secretory function by blocking stimulated Ca2+ entry.
    Maurer JA, Wenger BW, McKay DB.
    J Neurochem; 1996 Jan 22; 66(1):105-13. PubMed ID: 8522941
    [Abstract] [Full Text] [Related]

  • 5. Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in small cell lung carcinoma.
    Williams CL, Phelps SH, Porter RA.
    Biochem Pharmacol; 1996 Mar 08; 51(5):707-15. PubMed ID: 8615909
    [Abstract] [Full Text] [Related]

  • 6. Ca(2+)/calmodulin-dependent protein kinase II inhibitor KN-62 inhibits adrenal medullary chromaffin cell functions independent of its action on the kinase.
    Tsutsui M, Yanagihara N, Fukunaga K, Minami K, Nakashima Y, Kuroiwa A, Miyamoto E, Izumi F.
    J Neurochem; 1996 Jun 08; 66(6):2517-22. PubMed ID: 8632177
    [Abstract] [Full Text] [Related]

  • 7. Inhibition of angiotensin II- and potassium-mediated aldosterone secretion by KN-62 suggests involvement of Ca(2+)-calmodulin dependent protein kinase II in aldosterone secretion.
    Ganguly A, Li L, Haxton M.
    Biochem Biophys Res Commun; 1995 Apr 26; 209(3):916-20. PubMed ID: 7733984
    [Abstract] [Full Text] [Related]

  • 8. Inhibition of regulated catecholamine secretion from PC12 cells by the Ca2+/calmodulin kinase II inhibitor KN-62.
    Schweitzer ES, Sanderson MJ, Wasterlain CG.
    J Cell Sci; 1995 Jul 26; 108 ( Pt 7)():2619-28. PubMed ID: 7593303
    [Abstract] [Full Text] [Related]

  • 9. Inhibition of insulin secretion by KN-62, a specific inhibitor of the multifunctional Ca2+/calmodulin-dependent protein kinase II.
    Wenham RM, Landt M, Walters SM, Hidaka H, Easom RA.
    Biochem Biophys Res Commun; 1992 Nov 30; 189(1):128-33. PubMed ID: 1333187
    [Abstract] [Full Text] [Related]

  • 10. An inhibitor of Ca2+/calmodulin-dependent protein kinase II, KN-62, inhibits cholinergic-stimulated parietal cell secretion.
    Tsunoda Y, Funasaka M, Modlin IM, Hidaka H, Fox LM, Goldenring JR.
    Am J Physiol; 1992 Jan 30; 262(1 Pt 1):G118-22. PubMed ID: 1310221
    [Abstract] [Full Text] [Related]

  • 11. KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.
    Tokumitsu H, Chijiwa T, Hagiwara M, Mizutani A, Terasawa M, Hidaka H.
    J Biol Chem; 1990 Mar 15; 265(8):4315-20. PubMed ID: 2155222
    [Abstract] [Full Text] [Related]

  • 12. A selective Ca2+/calmodulin-dependent protein kinase II inhibitor, KN-62, inhibits the enhanced phosphorylation and the activation of tyrosine hydroxylase by 56 mM K+ in rat pheochromocytoma PC12h cells.
    Ishii A, Kiuchi K, Kobayashi R, Sumi M, Hidaka H, Nagatsu T.
    Biochem Biophys Res Commun; 1991 May 15; 176(3):1051-6. PubMed ID: 1674865
    [Abstract] [Full Text] [Related]

  • 13. Calcium/calmodulin-dependent protein kinase-II activation in rat pituitary cells in the presence of thyrotropin-releasing hormone and dopamine.
    Cui ZJ, Gorelick FS, Dannies PS.
    Endocrinology; 1994 May 15; 134(5):2245-50. PubMed ID: 8156928
    [Abstract] [Full Text] [Related]

  • 14. Inhibition of M3 muscarinic acetylcholine receptor-mediated Ca2+ influx and intracellular Ca2+ mobilization in neuroblastoma cells by the Ca2+/calmodulin-dependent protein kinase inhibitor 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-trosyl]-4-phenylpiperazin e (KN-62).
    Puhl HL, Raman PS, Williams CL, Aronstam RS.
    Biochem Pharmacol; 1997 Apr 25; 53(8):1107-14. PubMed ID: 9175715
    [Abstract] [Full Text] [Related]

  • 15. Effect of KN-62, Ca2+/calmodulin-dependent protein kinase II inhibitor, on adriamycin resistance of human ovarian cancer cells.
    Obata NH, Okazaki K, Maeda O, Kikkawa F, Tomoda Y, Hidaka H.
    Biochem Biophys Res Commun; 1995 Oct 13; 215(2):566-71. PubMed ID: 7487993
    [Abstract] [Full Text] [Related]

  • 16. Calcium/calmodulin-dependent protein kinase II involvement in release of gonadotropin-releasing hormone.
    Waters WW, Chen PL, McArthur NH, Moreno PA, Harms PG.
    Neuroendocrinology; 1998 Mar 13; 67(3):145-52. PubMed ID: 9630431
    [Abstract] [Full Text] [Related]

  • 17. KN-62, a specific Ca++/calmodulin-dependent protein kinase inhibitor, reversibly depresses the rate of beating of cultured fetal mouse cardiac myocytes.
    Okazaki K, Ishikawa T, Inui M, Tada M, Goshima K, Okamoto T, Hidaka H.
    J Pharmacol Exp Ther; 1994 Sep 13; 270(3):1319-24. PubMed ID: 7932185
    [Abstract] [Full Text] [Related]

  • 18. Flunarizine, a calcium influx blocker, inhibits TRH-but not potassium-stimulated prolactin secretion.
    Merritt JE, Tomlinson S, Brown BL.
    Acta Endocrinol (Copenh); 1984 Sep 13; 107(1):31-5. PubMed ID: 6435368
    [Abstract] [Full Text] [Related]

  • 19. A specific inhibitor of calcium/calmodulin-dependent protein kinase-II provides neuroprotection against NMDA- and hypoxia/hypoglycemia-induced cell death.
    Hajimohammadreza I, Probert AW, Coughenour LL, Borosky SA, Marcoux FW, Boxer PA, Wang KK.
    J Neurosci; 1995 May 13; 15(5 Pt 2):4093-101. PubMed ID: 7538570
    [Abstract] [Full Text] [Related]

  • 20. Dependence of insulin secretion from permeabilized pancreatic beta-cells on the activation of Ca(2+)/calmodulin-dependent protein kinase II. A re-evaluation of inhibitor studies.
    Bhatt HS, Conner BP, Prasanna G, Yorio T, Easom RA.
    Biochem Pharmacol; 2000 Dec 01; 60(11):1655-63. PubMed ID: 11077048
    [Abstract] [Full Text] [Related]

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