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Journal Abstract Search

168 related items for PubMed ID: 8605148

  • 1. Inhibition of trypsin and thrombin by amino(4-amidinophenyl)methanephosphonate diphenyl ester derivatives: X-ray structures and molecular models.
    Bertrand JA, Oleksyszyn J, Kam CM, Boduszek B, Presnell S, Plaskon RR, Suddath FL, Powers JC, Williams LD.
    Biochemistry; 1996 Mar 12; 35(10):3147-55. PubMed ID: 8605148
    [Abstract] [Full Text] [Related]

  • 2. Oxyanion-mediated inhibition of serine proteases.
    Presnell SR, Patil GS, Mura C, Jude KM, Conley JM, Bertrand JA, Kam CM, Powers JC, Williams LD.
    Biochemistry; 1998 Dec 01; 37(48):17068-81. PubMed ID: 9836602
    [Abstract] [Full Text] [Related]

  • 3. A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
    Katz BA, Elrod K, Luong C, Rice MJ, Mackman RL, Sprengeler PA, Spencer J, Hataye J, Janc J, Link J, Litvak J, Rai R, Rice K, Sideris S, Verner E, Young W.
    J Mol Biol; 2001 Apr 13; 307(5):1451-86. PubMed ID: 11292354
    [Abstract] [Full Text] [Related]

  • 4. Human alpha-thrombin inhibition by the active site titrant N alpha-(N,N-dimethylcarbamoyl)-alpha-azalysine p-nitrophenyl ester: a comparative kinetic and X-ray crystallographic study.
    Nardini M, Pesce A, Rizzi M, Casale E, Ferraccioli R, Balliano G, Milla P, Ascenzi P, Bolognesi M.
    J Mol Biol; 1996 May 24; 258(5):851-9. PubMed ID: 8637015
    [Abstract] [Full Text] [Related]

  • 5. Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9 A resolution.
    Tsunemi M, Matsuura Y, Sakakibara S, Katsube Y.
    Biochemistry; 1996 Sep 10; 35(36):11570-6. PubMed ID: 8794736
    [Abstract] [Full Text] [Related]

  • 6. Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6.
    Zdanov A, Wu S, DiMaio J, Konishi Y, Li Y, Wu X, Edwards BF, Martin PD, Cygler M.
    Proteins; 1993 Nov 10; 17(3):252-65. PubMed ID: 8272424
    [Abstract] [Full Text] [Related]

  • 7. Inhibition of human alpha-thrombin by a phosphonate tripeptide proceeds via a metastable pentacoordinated phosphorus intermediate.
    Skordalakes E, Dodson GG, Green DS, Goodwin CA, Scully MF, Hudson HR, Kakkar VV, Deadman JJ.
    J Mol Biol; 2001 Aug 17; 311(3):549-55. PubMed ID: 11493008
    [Abstract] [Full Text] [Related]

  • 8. Geometry of binding of the benzamidine- and arginine-based inhibitors N alpha-(2-naphthyl-sulphonyl-glycyl)-DL-p-amidinophenylalanyl-pipe ridine (NAPAP) and (2R,4R)-4-methyl-1-[N alpha-(3-methyl-1,2,3,4-tetrahydro-8- quinolinesulphonyl)-L-arginyl]-2-piperidine carboxylic acid (MQPA) to human alpha-thrombin. X-ray crystallographic determination of the NAPAP-trypsin complex and modeling of NAPAP-thrombin and MQPA-thrombin.
    Bode W, Turk D, Stürzebecher J.
    Eur J Biochem; 1990 Oct 05; 193(1):175-82. PubMed ID: 2226434
    [Abstract] [Full Text] [Related]

  • 9. Molecular design and characterization of an alpha-thrombin inhibitor containing a novel P1 moiety.
    Malikayil JA, Burkhart JP, Schreuder HA, Broersma RJ, Tardif C, Kutcher LW, Mehdi S, Schatzman GL, Neises B, Peet NP.
    Biochemistry; 1997 Feb 04; 36(5):1034-40. PubMed ID: 9033393
    [Abstract] [Full Text] [Related]

  • 10. Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes.
    Krishnan R, Zhang E, Hakansson K, Arni RK, Tulinsky A, Lim-Wilby MS, Levy OE, Semple JE, Brunck TK.
    Biochemistry; 1998 Sep 01; 37(35):12094-103. PubMed ID: 9724521
    [Abstract] [Full Text] [Related]

  • 11. In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
    Costanzo MJ, Almond HR, Hecker LR, Schott MR, Yabut SC, Zhang HC, Andrade-Gordon P, Corcoran TW, Giardino EC, Kauffman JA, Lewis JM, de Garavilla L, Haertlein BJ, Maryanoff BE.
    J Med Chem; 2005 Mar 24; 48(6):1984-2008. PubMed ID: 15771442
    [Abstract] [Full Text] [Related]

  • 12. Two crystal structures of the leupeptin-trypsin complex.
    Kurinov IV, Harrison RW.
    Protein Sci; 1996 Apr 24; 5(4):752-8. PubMed ID: 8845765
    [Abstract] [Full Text] [Related]

  • 13. Structure of the RWJ-51084-bovine pancreatic beta-trypsin complex at 1.8 A.
    Recacha R, Carson M, Costanzo MJ, Maryanoff B, DeLucas LJ, Chattopadhyay D.
    Acta Crystallogr D Biol Crystallogr; 1999 Nov 24; 55(Pt 11):1785-91. PubMed ID: 10531473
    [Abstract] [Full Text] [Related]

  • 14. The methyl group of N(alpha)(Me)Arg-containing peptides disturbs the active-site geometry of thrombin, impairing efficient cleavage.
    Friedrich R, Steinmetzer T, Huber R, Stürzebecher J, Bode W.
    J Mol Biol; 2002 Mar 01; 316(4):869-74. PubMed ID: 11884127
    [Abstract] [Full Text] [Related]

  • 15. Kunitz-type soybean trypsin inhibitor revisited: refined structure of its complex with porcine trypsin reveals an insight into the interaction between a homologous inhibitor from Erythrina caffra and tissue-type plasminogen activator.
    Song HK, Suh SW.
    J Mol Biol; 1998 Jan 16; 275(2):347-63. PubMed ID: 9466914
    [Abstract] [Full Text] [Related]

  • 16. Recruiting Zn2+ to mediate potent, specific inhibition of serine proteases.
    Katz BA, Luong C.
    J Mol Biol; 1999 Sep 24; 292(3):669-84. PubMed ID: 10497030
    [Abstract] [Full Text] [Related]

  • 17. Structure of a phosphonate-inhibited beta-lactamase. An analog of the tetrahedral transition state/intermediate of beta-lactam hydrolysis.
    Chen CC, Rahil J, Pratt RF, Herzberg O.
    J Mol Biol; 1993 Nov 05; 234(1):165-78. PubMed ID: 8230196
    [Abstract] [Full Text] [Related]

  • 18. Novel natural product 5,5-trans-lactone inhibitors of human alpha-thrombin: mechanism of action and structural studies.
    Weir MP, Bethell SS, Cleasby A, Campbell CJ, Dennis RJ, Dix CJ, Finch H, Jhoti H, Mooney CJ, Patel S, Tang CM, Ward M, Wonacott AJ, Wharton CW.
    Biochemistry; 1998 May 12; 37(19):6645-57. PubMed ID: 9578548
    [Abstract] [Full Text] [Related]

  • 19. X-ray crystallographic analyses of complexes between bovine beta-trypsin and Schiff base copper(II) or iron(III) chelates.
    Toyota E, Ng KK, Sekizaki H, Itoh K, Tanizawa K, James MN.
    J Mol Biol; 2001 Jan 19; 305(3):471-9. PubMed ID: 11152605
    [Abstract] [Full Text] [Related]

  • 20. Comparison of the structures of the cyclotheonamide A complexes of human alpha-thrombin and bovine beta-trypsin.
    Ganesh V, Lee AY, Clardy J, Tulinsky A.
    Protein Sci; 1996 May 19; 5(5):825-35. PubMed ID: 8732754
    [Abstract] [Full Text] [Related]

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