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Journal Abstract Search

215 related items for PubMed ID: 8615687

  • 1. Role of residue 480 in substrate specificity of cytochrome P450 2B5 and 2B11.
    Liu J, He YA, Halpert JR.
    Arch Biochem Biophys; 1996 Mar 01; 327(1):167-73. PubMed ID: 8615687
    [Abstract] [Full Text] [Related]

  • 2. Interconversion of the androstenedione hydroxylase specificities of cytochromes P450 2B4 and 2B5 upon simultaneous site-directed mutagenesis of four key substrate recognition residues.
    He YQ, Szklarz GD, Halpert JR.
    Arch Biochem Biophys; 1996 Nov 01; 335(1):152-60. PubMed ID: 8914846
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  • 4. Site-directed mutagenesis of putative substrate recognition sites in cytochrome P450 2B11: importance of amino acid residues 114, 290, and 363 for substrate specificity.
    Hasler JA, Harlow GR, Szklarz GD, John GH, Kedzie KM, Burnett VL, He YA, Kaminsky LS, Halpert JR.
    Mol Pharmacol; 1994 Aug 01; 46(2):338-45. PubMed ID: 8078495
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  • 5. Elucidation of amino acid residues critical for unique activities of rabbit cytochrome P450 2B5 using hybrid enzymes and reciprocal site-directed mutagenesis with rabbit cytochrome P450 2B4.
    Szklarz GD, He YQ, Kedzie KM, Halpert JR, Burnett VL.
    Arch Biochem Biophys; 1996 Mar 15; 327(2):308-18. PubMed ID: 8619620
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  • 6. Structural determinants of progesterone hydroxylation by cytochrome P450 2B5: the role of nonsubstrate recognition site residues.
    He YQ, Harlow GR, Szklarz GD, Halpert JR.
    Arch Biochem Biophys; 1998 Feb 15; 350(2):333-9. PubMed ID: 9473309
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  • 8. 2,2',3,3',6,6'-hexachlorobiphenyl hydroxylation by active site mutants of cytochrome P450 2B1 and 2B11.
    Waller SC, He YA, Harlow GR, He YQ, Mash EA, Halpert JR.
    Chem Res Toxicol; 1999 Aug 15; 12(8):690-9. PubMed ID: 10458702
    [Abstract] [Full Text] [Related]

  • 9. Mutagenesis study of Asp-290 in cytochrome P450 2B11 using a fusion protein with rat NADPH-cytochrome P450 reductase.
    Harlow GR, Halpert JR.
    Arch Biochem Biophys; 1996 Feb 01; 326(1):85-92. PubMed ID: 8579377
    [Abstract] [Full Text] [Related]

  • 10. Catalytic selectivity and mechanism-based inactivation of stably expressed and hepatic cytochromes P450 2B4 and 2B5: implications of the cytochrome P450 2B5 polymorphism.
    Grimm SW, Dyroff MC, Philpot RM, Halpert JR.
    Mol Pharmacol; 1994 Dec 01; 46(6):1090-9. PubMed ID: 7808429
    [Abstract] [Full Text] [Related]

  • 11. Activation of the anticancer prodrugs cyclophosphamide and ifosfamide: identification of cytochrome P450 2B enzymes and site-specific mutants with improved enzyme kinetics.
    Chen CS, Lin JT, Goss KA, He YA, Halpert JR, Waxman DJ.
    Mol Pharmacol; 2004 May 01; 65(5):1278-85. PubMed ID: 15102956
    [Abstract] [Full Text] [Related]

  • 12. Hydrophobic side chain requirements for lauric acid and progesterone hydroxylation at amino acid 113 in cytochrome P450 2C2, a potential determinant of substrate specificity.
    Straub P, Johnson EF, Kemper B.
    Arch Biochem Biophys; 1993 Nov 01; 306(2):521-7. PubMed ID: 8215458
    [Abstract] [Full Text] [Related]

  • 13. Role of residues 363 and 206 in conversion of cytochrome P450 2B1 from a steroid 16-hydroxylase to a 15 alpha-hydroxylase.
    Luo Z, He YA, Halpert JR.
    Arch Biochem Biophys; 1994 Feb 15; 309(1):52-7. PubMed ID: 8117113
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  • 14. Alterations of the regiospecificity of progesterone metabolism by the mutagenesis of two key amino acid residues in rabbit cytochrome P450 2C3v.
    Richardson TH, Johnson EF.
    J Biol Chem; 1994 Sep 30; 269(39):23937-43. PubMed ID: 7929041
    [Abstract] [Full Text] [Related]

  • 15. Escherichia coli expression of site-directed mutants of cytochrome P450 2B1 from six substrate recognition sites: substrate specificity and inhibitor selectivity studies.
    He YQ, He YA, Halpert JR.
    Chem Res Toxicol; 1995 Jun 30; 8(4):574-9. PubMed ID: 7548737
    [Abstract] [Full Text] [Related]

  • 16. Engineering of cytochrome P450 2B1 specificity. Conversion of an androgen 16 beta-hydroxylase to a 15 alpha-hydroxylase.
    Halpert JR, He YA.
    J Biol Chem; 1993 Feb 25; 268(6):4453-7. PubMed ID: 8440727
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  • 18. Functional interaction between amino-acid residues 242 and 290 in cytochromes P-450 2B1 and 2B11.
    Harlow GR, He YA, Halpert JR.
    Biochim Biophys Acta; 1997 Apr 04; 1338(2):259-66. PubMed ID: 9128144
    [Abstract] [Full Text] [Related]

  • 19. Hybrid enzymes for structure-function analysis of cytochrome P-450 2B11.
    Kedzie KM, Grimm SW, Chen F, Halpert JR.
    Biochim Biophys Acta; 1993 Jul 10; 1164(2):124-32. PubMed ID: 8329443
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