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495 related items for PubMed ID: 8615909

  • 1. Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl piperazine) in small cell lung carcinoma.
    Williams CL, Phelps SH, Porter RA.
    Biochem Pharmacol; 1996 Mar 08; 51(5):707-15. PubMed ID: 8615909
    [Abstract] [Full Text] [Related]

  • 2. Inhibition of voltage-gated Ca2+ channel activity in small cell lung carcinoma by the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperaz ine) .
    Williams CL, Porter RA, Phelps SH.
    Biochem Pharmacol; 1995 Dec 22; 50(12):1979-85. PubMed ID: 8849323
    [Abstract] [Full Text] [Related]

  • 3. KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.
    Tokumitsu H, Chijiwa T, Hagiwara M, Mizutani A, Terasawa M, Hidaka H.
    J Biol Chem; 1990 Mar 15; 265(8):4315-20. PubMed ID: 2155222
    [Abstract] [Full Text] [Related]

  • 4. Inhibition of M3 muscarinic acetylcholine receptor-mediated Ca2+ influx and intracellular Ca2+ mobilization in neuroblastoma cells by the Ca2+/calmodulin-dependent protein kinase inhibitor 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-trosyl]-4-phenylpiperazin e (KN-62).
    Puhl HL, Raman PS, Williams CL, Aronstam RS.
    Biochem Pharmacol; 1997 Apr 25; 53(8):1107-14. PubMed ID: 9175715
    [Abstract] [Full Text] [Related]

  • 5. A possible role for Ca(2+)/calmodulin-dependent protein kinase IV during pancreatic acinar stimulus-secretion coupling.
    Yoshida H, Nozu F, Lankisch TO, Mitamura K, Owyang C, Tsunoda Y.
    Biochim Biophys Acta; 2000 Jun 02; 1497(1):155-67. PubMed ID: 10838169
    [Abstract] [Full Text] [Related]

  • 6. Inhibition of voltage-gated Ca2+ channels and insulin secretion in HIT cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-62: comparison with antagonists of calmodulin and L-type Ca2+ channels.
    Li G, Hidaka H, Wollheim CB.
    Mol Pharmacol; 1992 Sep 02; 42(3):489-8. PubMed ID: 1328847
    [Abstract] [Full Text] [Related]

  • 7. 1-[N, O-bis-(5-isoquinolinesulphonyl)-N-methyl-L-tyrosyl]-4- phenylpiperazine (KN-62), an inhibitor of calcium-dependent camodulin protein kinase II, inhibits both insulin- and hypoxia-stimulated glucose transport in skeletal muscle.
    Brozinick JT, Reynolds TH, Dean D, Cartee G, Cushman SW.
    Biochem J; 1999 May 01; 339 ( Pt 3)(Pt 3):533-40. PubMed ID: 10215590
    [Abstract] [Full Text] [Related]

  • 8. The effect of KN-62, Ca2+/calmodulin dependent protein kinase II inhibitor on cell cycle.
    Minami H, Inoue S, Hidaka H.
    Biochem Biophys Res Commun; 1994 Feb 28; 199(1):241-8. PubMed ID: 8123019
    [Abstract] [Full Text] [Related]

  • 9. KN-62, a specific Ca++/calmodulin-dependent protein kinase inhibitor, reversibly depresses the rate of beating of cultured fetal mouse cardiac myocytes.
    Okazaki K, Ishikawa T, Inui M, Tada M, Goshima K, Okamoto T, Hidaka H.
    J Pharmacol Exp Ther; 1994 Sep 28; 270(3):1319-24. PubMed ID: 7932185
    [Abstract] [Full Text] [Related]

  • 10. Ca(2+)/calmodulin-dependent protein kinase II inhibitor KN-62 inhibits adrenal medullary chromaffin cell functions independent of its action on the kinase.
    Tsutsui M, Yanagihara N, Fukunaga K, Minami K, Nakashima Y, Kuroiwa A, Miyamoto E, Izumi F.
    J Neurochem; 1996 Jun 28; 66(6):2517-22. PubMed ID: 8632177
    [Abstract] [Full Text] [Related]

  • 11. Dependence of insulin secretion from permeabilized pancreatic beta-cells on the activation of Ca(2+)/calmodulin-dependent protein kinase II. A re-evaluation of inhibitor studies.
    Bhatt HS, Conner BP, Prasanna G, Yorio T, Easom RA.
    Biochem Pharmacol; 2000 Dec 01; 60(11):1655-63. PubMed ID: 11077048
    [Abstract] [Full Text] [Related]

  • 12. Neurite outgrowth of neuroblastoma cells overexpressing alpha and beta isoforms of Ca2+/calmodulin-dependent protein kinase II-effects of protein kinase inhibitors.
    Yamauchi T, Yoshimura Y, Nomura T, Fujii M, Sugiura H.
    Brain Res Brain Res Protoc; 1998 Jun 01; 2(4):250-8. PubMed ID: 9630658
    [Abstract] [Full Text] [Related]

  • 13. Mediation of pepsinogen secretion from guinea pig chief cells by Ca2+/calmodulin-dependent protein kinase II.
    Okayama N, Itoh M, Joh T, Miyamoto T, Takeuchi T, Suzuki T, Moriyama A, Kato T.
    Biochim Biophys Acta; 1995 Aug 31; 1268(2):123-9. PubMed ID: 7662698
    [Abstract] [Full Text] [Related]

  • 14. Inhibition of regulated catecholamine secretion from PC12 cells by the Ca2+/calmodulin kinase II inhibitor KN-62.
    Schweitzer ES, Sanderson MJ, Wasterlain CG.
    J Cell Sci; 1995 Jul 31; 108 ( Pt 7)():2619-28. PubMed ID: 7593303
    [Abstract] [Full Text] [Related]

  • 15. A selective Ca2+/calmodulin-dependent protein kinase II inhibitor, KN-62, inhibits the enhanced phosphorylation and the activation of tyrosine hydroxylase by 56 mM K+ in rat pheochromocytoma PC12h cells.
    Ishii A, Kiuchi K, Kobayashi R, Sumi M, Hidaka H, Nagatsu T.
    Biochem Biophys Res Commun; 1991 May 15; 176(3):1051-6. PubMed ID: 1674865
    [Abstract] [Full Text] [Related]

  • 16. Effect of KN-62, Ca2+/calmodulin-dependent protein kinase II inhibitor, on adriamycin resistance of human ovarian cancer cells.
    Obata NH, Okazaki K, Maeda O, Kikkawa F, Tomoda Y, Hidaka H.
    Biochem Biophys Res Commun; 1995 Oct 13; 215(2):566-71. PubMed ID: 7487993
    [Abstract] [Full Text] [Related]

  • 17. Retinoic acid-stimulated intercellular adhesion molecule-1 expression on SK-N-SH cells: calcium/calmodulin-dependent pathway.
    Bouillon M, Audette M.
    Cancer Res; 1994 Aug 01; 54(15):4144-9. PubMed ID: 7913411
    [Abstract] [Full Text] [Related]

  • 18. Effect of a new Ca2(+)-calmodulin-dependent protein kinase II inhibitor on GABA release in cerebrospinal fluid of the rat.
    Ishikawa N, Hashiba Y, Hidaka H.
    J Pharmacol Exp Ther; 1990 Aug 01; 254(2):598-602. PubMed ID: 2384887
    [Abstract] [Full Text] [Related]

  • 19. Effects of protein kinase inhibitors on morphology and function of cultured bovine adrenal chromaffin cells: KN-62 inhibits secretory function by blocking stimulated Ca2+ entry.
    Maurer JA, Wenger BW, McKay DB.
    J Neurochem; 1996 Jan 01; 66(1):105-13. PubMed ID: 8522941
    [Abstract] [Full Text] [Related]

  • 20. Reversible phosphorylation as a controlling factor for sustaining calcium oscillations in HeLa cells: Involvement of calmodulin-dependent kinase II and a calyculin A-inhibitable phosphatase.
    Zhu DM, Tekle E, Chock PB, Huang CY.
    Biochemistry; 1996 Jun 04; 35(22):7214-23. PubMed ID: 8679550
    [Abstract] [Full Text] [Related]

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