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214 related items for PubMed ID: 8621426

  • 1. Defective fatty acid-mediated beta-cell compensation in Zucker diabetic fatty rats. Pathogenic implications for obesity-dependent diabetes.
    Hirose H, Lee YH, Inman LR, Nagasawa Y, Johnson JH, Unger RH.
    J Biol Chem; 1996 Mar 08; 271(10):5633-7. PubMed ID: 8621426
    [Abstract] [Full Text] [Related]

  • 2. Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes.
    Shimabukuro M, Zhou YT, Levi M, Unger RH.
    Proc Natl Acad Sci U S A; 1998 Mar 03; 95(5):2498-502. PubMed ID: 9482914
    [Abstract] [Full Text] [Related]

  • 3. Increased lipogenic capacity of the islets of obese rats: a role in the pathogenesis of NIDDM.
    Lee Y, Hirose H, Zhou YT, Esser V, McGarry JD, Unger RH.
    Diabetes; 1997 Mar 03; 46(3):408-13. PubMed ID: 9032096
    [Abstract] [Full Text] [Related]

  • 4. Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids.
    Milburn JL, Hirose H, Lee YH, Nagasawa Y, Ogawa A, Ohneda M, BeltrandelRio H, Newgard CB, Johnson JH, Unger RH.
    J Biol Chem; 1995 Jan 20; 270(3):1295-9. PubMed ID: 7836394
    [Abstract] [Full Text] [Related]

  • 5. Lipid-induced beta-cell dysfunction in vivo in models of progressive beta-cell failure.
    Goh TT, Mason TM, Gupta N, So A, Lam TK, Lam L, Lewis GF, Mari A, Giacca A.
    Am J Physiol Endocrinol Metab; 2007 Feb 20; 292(2):E549-60. PubMed ID: 17003242
    [Abstract] [Full Text] [Related]

  • 6. Leptin normalizes the impaired response of proinsulin mRNA to long chain fatty acids in heterozygous Zucker diabetic fatty rats.
    Zhou YT, Shimabukuro M, Lee Y, Koyama K, Trieu F, Unger RH.
    J Biol Chem; 1997 Oct 10; 272(41):25648-51. PubMed ID: 9325287
    [Abstract] [Full Text] [Related]

  • 7. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.
    Unger RH.
    Diabetes; 1995 Aug 10; 44(8):863-70. PubMed ID: 7621989
    [Abstract] [Full Text] [Related]

  • 8. Basal insulin hypersecretion in insulin-resistant Zucker diabetic and Zucker fatty rats: role of enhanced fuel metabolism.
    Zhou YP, Cockburn BN, Pugh W, Polonsky KS.
    Metabolism; 1999 Jul 10; 48(7):857-64. PubMed ID: 10421226
    [Abstract] [Full Text] [Related]

  • 9. Enhanced de novo lipogenesis in the leptin-unresponsive pancreatic islets of prediabetic Zucker diabetic fatty rats: role in the pathogenesis of lipotoxic diabetes.
    Zhou YT, Shimabukuro M, Lee Y, Koyama K, Higa M, Ferguson T, Unger RH.
    Diabetes; 1998 Dec 10; 47(12):1904-8. PubMed ID: 9836522
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  • 11. Variation in characteristics of islets of Langerhans in insulin-resistant, diabetic and non-diabetic-rat strains.
    Jones HB, Nugent D, Jenkins R.
    Int J Exp Pathol; 2010 Jun 10; 91(3):288-301. PubMed ID: 20384904
    [Abstract] [Full Text] [Related]

  • 12. Beta-cell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death.
    Finegood DT, McArthur MD, Kojwang D, Thomas MJ, Topp BG, Leonard T, Buckingham RE.
    Diabetes; 2001 May 10; 50(5):1021-9. PubMed ID: 11334404
    [Abstract] [Full Text] [Related]

  • 13. Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships.
    Lee Y, Hirose H, Ohneda M, Johnson JH, McGarry JD, Unger RH.
    Proc Natl Acad Sci U S A; 1994 Nov 08; 91(23):10878-82. PubMed ID: 7971976
    [Abstract] [Full Text] [Related]

  • 14. Alterations in pulsatile insulin secretion in the Zucker diabetic fatty rat.
    Sturis J, Pugh WL, Tang J, Ostrega DM, Polonsky JS, Polonsky KS.
    Am J Physiol; 1994 Aug 08; 267(2 Pt 1):E250-9. PubMed ID: 8074204
    [Abstract] [Full Text] [Related]

  • 15. Low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of Zucker diabetic fatty rats.
    MacDonald MJ, Tang J, Polonsky KS.
    Diabetes; 1996 Nov 08; 45(11):1626-30. PubMed ID: 8866570
    [Abstract] [Full Text] [Related]

  • 16. Beta cell compensation for insulin resistance in Zucker fatty rats: increased lipolysis and fatty acid signalling.
    Nolan CJ, Leahy JL, Delghingaro-Augusto V, Moibi J, Soni K, Peyot ML, Fortier M, Guay C, Lamontagne J, Barbeau A, Przybytkowski E, Joly E, Masiello P, Wang S, Mitchell GA, Prentki M.
    Diabetologia; 2006 Sep 08; 49(9):2120-30. PubMed ID: 16868750
    [Abstract] [Full Text] [Related]

  • 17. Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion.
    Wang MY, Koyama K, Shimabukuro M, Mangelsdorf D, Newgard CB, Unger RH.
    Proc Natl Acad Sci U S A; 1998 Sep 29; 95(20):11921-6. PubMed ID: 9751766
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  • 19. Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells.
    Patanè G, Piro S, Rabuazzo AM, Anello M, Vigneri R, Purrello F.
    Diabetes; 2000 May 29; 49(5):735-40. PubMed ID: 10905481
    [Abstract] [Full Text] [Related]

  • 20. Impact of alogliptin and pioglitazone on lipid metabolism in islets of prediabetic and diabetic Zucker Diabetic Fatty rats.
    Cai Y, Lydic TA, Turkette T, Reid GE, Olson LK.
    Biochem Pharmacol; 2015 May 01; 95(1):46-57. PubMed ID: 25801003
    [Abstract] [Full Text] [Related]

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