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551 related items for PubMed ID: 8621605

  • 1. Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus.
    Thinakaran G, Teplow DB, Siman R, Greenberg B, Sisodia SS.
    J Biol Chem; 1996 Apr 19; 271(16):9390-7. PubMed ID: 8621605
    [Abstract] [Full Text] [Related]

  • 2. Spatial-Temporal Mapping Reveals the Golgi as the Major Processing Site for the Pathogenic Swedish APP Mutation: Familial APP Mutant Shifts the Major APP Processing Site.
    Wang J, Gleeson PA, Fourriere L.
    Traffic; 2024 Mar 19; 25(3):e12932. PubMed ID: 38528836
    [Abstract] [Full Text] [Related]

  • 3. Cleavage of Alzheimer's amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway. Identification of intracellular compartments in which APP cleavage occurs without using toxic agents that interfere with protein metabolism.
    Tomita S, Kirino Y, Suzuki T.
    J Biol Chem; 1998 Mar 13; 273(11):6277-84. PubMed ID: 9497354
    [Abstract] [Full Text] [Related]

  • 4. The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway.
    Haass C, Lemere CA, Capell A, Citron M, Seubert P, Schenk D, Lannfelt L, Selkoe DJ.
    Nat Med; 1995 Dec 13; 1(12):1291-6. PubMed ID: 7489411
    [Abstract] [Full Text] [Related]

  • 5. Differential effects of a Rab6 mutant on secretory versus amyloidogenic processing of Alzheimer's beta-amyloid precursor protein.
    McConlogue L, Castellano F, deWit C, Schenk D, Maltese WA.
    J Biol Chem; 1996 Jan 19; 271(3):1343-8. PubMed ID: 8576122
    [Abstract] [Full Text] [Related]

  • 6. Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells.
    Parvathy S, Hussain I, Karran EH, Turner AJ, Hooper NM.
    Biochemistry; 1999 Jul 27; 38(30):9728-34. PubMed ID: 10423252
    [Abstract] [Full Text] [Related]

  • 7. Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer's mice.
    Li S, Hou H, Mori T, Sawmiller D, Smith A, Tian J, Wang Y, Giunta B, Sanberg PR, Zhang S, Tan J.
    Sci Rep; 2015 Jun 19; 5():11322. PubMed ID: 26091071
    [Abstract] [Full Text] [Related]

  • 8. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
    Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M.
    Science; 1999 Oct 22; 286(5440):735-41. PubMed ID: 10531052
    [Abstract] [Full Text] [Related]

  • 9. The Alzheimer beta-amyloid protein precursor/protease nexin-II is cleaved by secretase in a trans-Golgi secretory compartment in human neuroglioma cells.
    Kuentzel SL, Ali SM, Altman RA, Greenberg BD, Raub TJ.
    Biochem J; 1993 Oct 15; 295 ( Pt 2)(Pt 2):367-78. PubMed ID: 8240235
    [Abstract] [Full Text] [Related]

  • 10. Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network.
    Skovronsky DM, Moore DB, Milla ME, Doms RW, Lee VM.
    J Biol Chem; 2000 Jan 28; 275(4):2568-75. PubMed ID: 10644715
    [Abstract] [Full Text] [Related]

  • 11. ELISA analysis of beta-secretase cleavage of the Swedish amyloid precursor protein in the secretory and endocytic pathways.
    Steinhilb ML, Turner RS, Gaut JR.
    J Neurochem; 2002 Mar 28; 80(6):1019-28. PubMed ID: 11953452
    [Abstract] [Full Text] [Related]

  • 12. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
    Deng Y, Wang Z, Wang R, Zhang X, Zhang S, Wu Y, Staufenbiel M, Cai F, Song W.
    Eur J Neurosci; 2013 Jun 28; 37(12):1962-9. PubMed ID: 23773065
    [Abstract] [Full Text] [Related]

  • 13. Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells.
    Lo AC, Haass C, Wagner SL, Teplow DB, Sisodia SS.
    J Biol Chem; 1994 Dec 09; 269(49):30966-73. PubMed ID: 7983032
    [Abstract] [Full Text] [Related]

  • 14. The phosphatidylinositol 3-kinase inhibitor wortmannin alters the metabolism of the Alzheimer's amyloid precursor protein.
    Petanceska SS, Gandy S.
    J Neurochem; 1999 Dec 09; 73(6):2316-20. PubMed ID: 10582589
    [Abstract] [Full Text] [Related]

  • 15. Amyloid precursor protein compartmentalization restricts beta-amyloid production: therapeutic targets based on BACE compartmentalization.
    Gandhi S, Refolo LM, Sambamurti K.
    J Mol Neurosci; 2004 Dec 09; 24(1):137-43. PubMed ID: 15314262
    [Abstract] [Full Text] [Related]

  • 16. Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease.
    Lammich S, Kojro E, Postina R, Gilbert S, Pfeiffer R, Jasionowski M, Haass C, Fahrenholz F.
    Proc Natl Acad Sci U S A; 1999 Mar 30; 96(7):3922-7. PubMed ID: 10097139
    [Abstract] [Full Text] [Related]

  • 17. Pulse-chase experiments revealed beta-secretase cleavage from immature full-length amyloid precursor protein harboring the Swedish mutation. Implications for distinct pathways.
    Urmoneit B, Turner J, Dyrks T.
    J Mol Neurosci; 1998 Oct 30; 11(2):141-50. PubMed ID: 10096041
    [Abstract] [Full Text] [Related]

  • 18. Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence.
    Kimura A, Hata S, Suzuki T.
    J Biol Chem; 2016 Nov 11; 291(46):24041-24053. PubMed ID: 27687728
    [Abstract] [Full Text] [Related]

  • 19. Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells.
    Shi XP, Tugusheva K, Bruce JE, Lucka A, Chen-Dodson E, Hu B, Wu GX, Price E, Register RB, Lineberger J, Miller R, Tang MJ, Espeseth A, Kahana J, Wolfe A, Crouthamel MC, Sankaranarayanan S, Simon A, Chen L, Lai MT, Pietrak B, DiMuzio J, Li Y, Xu M, Huang Q, Garsky V, Sardana MK, Hazuda DJ.
    J Alzheimers Dis; 2005 Apr 11; 7(2):139-48; discussion 173-80. PubMed ID: 15851852
    [Abstract] [Full Text] [Related]

  • 20. Generation of amyloid beta protein from its precursor is sequence specific.
    Citron M, Teplow DB, Selkoe DJ.
    Neuron; 1995 Mar 11; 14(3):661-70. PubMed ID: 7695913
    [Abstract] [Full Text] [Related]

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