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180 related items for PubMed ID: 8623162

  • 1. Depletion of the mature CD4+8- thymocyte subset by FK506 analogs correlates with their immunosuppressive and calcineurin inhibitory activities.
    Koprak S, Sirotina A, Ok H, Dumont FJ.
    Transplantation; 1996 Mar 27; 61(6):926-32. PubMed ID: 8623162
    [Abstract] [Full Text] [Related]

  • 2. T cell receptor-mediated signaling events in CD4+CD8+ thymocytes undergoing thymic selection: requirement of calcineurin activation for thymic positive selection but not negative selection.
    Wang CR, Hashimoto K, Kubo S, Yokochi T, Kubo M, Suzuki M, Suzuki K, Tada T, Nakayama T.
    J Exp Med; 1995 Mar 01; 181(3):927-41. PubMed ID: 7532685
    [Abstract] [Full Text] [Related]

  • 3. The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein.
    Odom A, Del Poeta M, Perfect J, Heitman J.
    Antimicrob Agents Chemother; 1997 Jan 01; 41(1):156-61. PubMed ID: 8980772
    [Abstract] [Full Text] [Related]

  • 4. Disruption of T cell development and repertoire selection by calcineurin inhibition in vivo.
    Holländer GA, Fruman DA, Bierer BE, Burakoff SJ.
    Transplantation; 1994 Nov 15; 58(9):1037-43. PubMed ID: 7526495
    [Abstract] [Full Text] [Related]

  • 5. The immunosuppressive drugs cyclosporin A and FK506 inhibit calcineurin phosphatase activity and gene transcription mediated through the cAMP-responsive element in a nonimmune cell line.
    Schwaninger M, Blume R, Oetjen E, Knepel W.
    Naunyn Schmiedebergs Arch Pharmacol; 1993 Nov 15; 348(5):541-5. PubMed ID: 7509460
    [Abstract] [Full Text] [Related]

  • 6. The complex of FK506-binding protein 12 and FK506 inhibits calcineurin phosphatase activity and IgE activation-induced cytokine transcripts, but not exocytosis, in mouse mast cells.
    Fruman DA, Bierer BE, Benes JE, Burakoff SJ, Austen KF, Katz HR.
    J Immunol; 1995 Feb 15; 154(4):1846-51. PubMed ID: 7530743
    [Abstract] [Full Text] [Related]

  • 7. Evidence that the inhibition of Na+/K(+)-ATPase activity by FK506 involves calcineurin.
    Lea JP, Sands JM, McMahon SJ, Tumlin JA.
    Kidney Int; 1994 Sep 15; 46(3):647-52. PubMed ID: 7527873
    [Abstract] [Full Text] [Related]

  • 8. FKBP12-FK506 complex inhibits phosphatase activity of two mammalian isoforms of calcineurin irrespective of their substrates or activation mechanisms.
    Mukai H, Kuno T, Chang CD, Lane B, Luly JR, Tanaka C.
    J Biochem; 1993 Mar 15; 113(3):292-8. PubMed ID: 7683641
    [Abstract] [Full Text] [Related]

  • 9. The effects of FK506 and dexamethasone on rat thymocyte differentiation.
    Tsuchida M, Takai K, Jojima K, Naito K, Fujikura Y, Fukumoto T.
    Ther Immunol; 1994 Jun 15; 1(3):135-41. PubMed ID: 7584489
    [Abstract] [Full Text] [Related]

  • 10. Mixed agonist/antagonist activity of an FK-506-related immunosuppressant: biological and biochemical characterization.
    Dumont FJ, Ok H, Lin S, Kastner CA, Cryan J, Martin MM, Wiederrecht G, Staruch MJ.
    J Pharmacol Exp Ther; 1996 Mar 15; 276(3):1078-88. PubMed ID: 8786538
    [Abstract] [Full Text] [Related]

  • 11. The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin.
    Dumont FJ, Staruch MJ, Koprak SL, Siekierka JJ, Lin CS, Harrison R, Sewell T, Kindt VM, Beattie TR, Wyvratt M.
    J Exp Med; 1992 Sep 01; 176(3):751-60. PubMed ID: 1380976
    [Abstract] [Full Text] [Related]

  • 12. FK506, a Ca2+/calmodulin-dependent phosphatase inhibitor, inhibits the induction of long-term potentiation in the rat hippocampus.
    Lu YF, Hayashi Y, Moriwaki A, Tomizawa K, Matsui H.
    Neurosci Lett; 1996 Feb 23; 205(2):103-6. PubMed ID: 8907327
    [Abstract] [Full Text] [Related]

  • 13. Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity.
    Liu J, Albers MW, Wandless TJ, Luan S, Alberg DG, Belshaw PJ, Cohen P, MacKintosh C, Klee CB, Schreiber SL.
    Biochemistry; 1992 Apr 28; 31(16):3896-901. PubMed ID: 1373650
    [Abstract] [Full Text] [Related]

  • 14. Immunosuppressants and calcineurin inhibitors, cyclosporin A and FK506, reversibly inhibit epileptogenesis in amygdaloid kindled rat.
    Moia LJ, Matsui H, de Barros GA, Tomizawa K, Miyamoto K, Kuwata Y, Tokuda M, Itano T, Hatase O.
    Brain Res; 1994 Jun 20; 648(2):337-41. PubMed ID: 7522929
    [Abstract] [Full Text] [Related]

  • 15. Modeling the interaction between FK506 and FKBP12: a mechanism for formation of the calcineurin inhibitory complex.
    Ivery MT, Weiler L.
    Bioorg Med Chem; 1997 Feb 20; 5(2):217-32. PubMed ID: 9061187
    [Abstract] [Full Text] [Related]

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  • 17. A role for calcineurin in degranulation of murine cytotoxic T lymphocytes.
    Dutz JP, Fruman DA, Burakoff SJ, Bierer BE.
    J Immunol; 1993 Apr 01; 150(7):2591-8. PubMed ID: 7681074
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  • 19. A role for calcium influx in setting the threshold for CD4+CD8+ thymocyte negative selection.
    Kane LP, Hedrick SM.
    J Immunol; 1996 Jun 15; 156(12):4594-601. PubMed ID: 8648101
    [Abstract] [Full Text] [Related]

  • 20. Duration of calcineurin and Erk signals regulates CD4/CD8 lineage commitment of thymocytes.
    Adachi S, Iwata M.
    Cell Immunol; 2002 Jan 15; 215(1):45-53. PubMed ID: 12142035
    [Abstract] [Full Text] [Related]

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