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87 related items for PubMed ID: 8630013

  • 1. Cysteine-699, a possible palmitoylation site of the thyrotropin receptor, is not crucial for cAMP or phosphoinositide signaling but is necessary for full surface expression.
    Kosugi S, Mori T.
    Biochem Biophys Res Commun; 1996 Apr 25; 221(3):636-40. PubMed ID: 8630013
    [Abstract] [Full Text] [Related]

  • 2. The intracellular region adjacent to plasma membrane (residues 684-692) of the thyrotropin receptor is important for phosphoinositide signaling but not for agonist-induced adenylate cyclase activation.
    Kosugi S, Mori T.
    Biochem Biophys Res Commun; 1994 Mar 30; 199(3):1497-503. PubMed ID: 8147896
    [Abstract] [Full Text] [Related]

  • 3. The amino-terminal half of the cytoplasmic tail of the thyrotropin receptor is essential for full activities of receptor function.
    Kosugi S, Mori T.
    Biochem Biophys Res Commun; 1994 Apr 15; 200(1):401-7. PubMed ID: 8166712
    [Abstract] [Full Text] [Related]

  • 4. Constitutive activation of the thyrotropin receptor by mutating CYS-636 in the sixth transmembrane segment.
    Kosugi S, Mori T.
    Biochem Biophys Res Commun; 1996 May 24; 222(3):713-7. PubMed ID: 8651910
    [Abstract] [Full Text] [Related]

  • 5. Substitutions of different regions of the third cytoplasmic loop of the thyrotropin (TSH) receptor have selective effects on constitutive, TSH-, and TSH receptor autoantibody-stimulated phosphoinositide and 3',5'-cyclic adenosine monophosphate signal generation.
    Kosugi S, Okajima F, Ban T, Hidaka A, Shenker A, Kohn LD.
    Mol Endocrinol; 1993 Aug 24; 7(8):1009-20. PubMed ID: 7901757
    [Abstract] [Full Text] [Related]

  • 6. The middle portion in the second cytoplasmic loop of the thyrotropin receptor plays a crucial role in adenylate cyclase activation.
    Kosugi S, Kohn LD, Akamizu T, Mori T.
    Mol Endocrinol; 1994 Apr 24; 8(4):498-509. PubMed ID: 7914349
    [Abstract] [Full Text] [Related]

  • 7. The first cytoplasmic loop of the thyrotropin receptor is important for phosphoinositide signaling but not for agonist-induced adenylate cyclase activation.
    Kosugi S, Mori T.
    FEBS Lett; 1994 Mar 21; 341(2-3):162-6. PubMed ID: 8137933
    [Abstract] [Full Text] [Related]

  • 8. Mutation of alanine 623 in the third cytoplasmic loop of the rat thyrotropin (TSH) receptor results in a loss in the phosphoinositide but not cAMP signal induced by TSH and receptor autoantibodies.
    Kosugi S, Okajima F, Ban T, Hidaka A, Shenker A, Kohn LD.
    J Biol Chem; 1992 Dec 05; 267(34):24153-6. PubMed ID: 1332945
    [Abstract] [Full Text] [Related]

  • 9. Possible difference in glycosylation of the thyrotropin receptor among species.
    Kosugi S, Akamizu T, Mori T.
    Biochem Biophys Res Commun; 1994 May 16; 200(3):1207-13. PubMed ID: 8185569
    [Abstract] [Full Text] [Related]

  • 10. Functional thyrotropin receptor expression in the pituitary folliculo-stellate cell line TtT/GF.
    Brokken LJ, Bakker O, Wiersinga WM, Prummel MF.
    Exp Clin Endocrinol Diabetes; 2005 Jan 16; 113(1):13-20. PubMed ID: 15662590
    [Abstract] [Full Text] [Related]

  • 11. Point mutations of the thyrotropin receptor determining structural requirements for its ability to bind thyrotropin and to stimulate adenylate cyclase activity.
    Gustavsson B, Westermark B, Heldin NE.
    Biochem Biophys Res Commun; 1994 Mar 15; 199(2):612-8. PubMed ID: 8135801
    [Abstract] [Full Text] [Related]

  • 12. Occupancy of both sites on the thyrotropin (TSH) receptor dimer is necessary for phosphoinositide signaling.
    Allen MD, Neumann S, Gershengorn MC.
    FASEB J; 2011 Oct 15; 25(10):3687-94. PubMed ID: 21705666
    [Abstract] [Full Text] [Related]

  • 13. Carboxyl tail cysteine mutants of the thyrotropin-releasing hormone receptor type 1 exhibit constitutive signaling: role of palmitoylation.
    Du D, Raaka BM, Grimberg H, Lupu-Meiri M, Oron Y, Gershengorn MC.
    Mol Pharmacol; 2005 Jul 15; 68(1):204-9. PubMed ID: 15833733
    [Abstract] [Full Text] [Related]

  • 14. Cysteine 390 mutation of the TSH receptor modulates its ectodomain as an inverse agonist on the serpentine domain with decrease in basal constitutive activity.
    Ho SC, Goh SS, Su Q, Khoo DH.
    Mol Cell Endocrinol; 2005 Dec 21; 245(1-2):158-68. PubMed ID: 16364538
    [Abstract] [Full Text] [Related]

  • 15. Further studies of amino acids (268-304) in thyrotropin (TSH)--lutropin/chorionic gonadotropin (LH/CG) receptor chimeras: cysteine-301 is important in TSH binding and receptor tertiary structure.
    Akamizu T, Inoue D, Kosugi S, Kohn LD, Mori T.
    Thyroid; 1994 Dec 21; 4(1):43-8. PubMed ID: 8054860
    [Abstract] [Full Text] [Related]

  • 16. Effects of mutations involving cysteine residues distal to the S281HCC motif at the C-terminus on the functional characteristics of a truncated ectodomain-only thyrotropin receptor anchored on glycosylphosphatidyl-inositol.
    Ho SC, Goh SS, Li S, Khoo DH, Paterson M.
    Thyroid; 2008 Dec 21; 18(12):1313-9. PubMed ID: 18976165
    [Abstract] [Full Text] [Related]

  • 17. Chimeric studies of the extracellular domain of the rat thyrotropin (TSH) receptor: amino acids (268-304) in the TSH receptor are involved in ligand high affinity binding, but not in TSH receptor-specific signal transduction.
    Akamizu T, Inoue D, Kosugi S, Ban T, Kohn LD, Imura H, Mori T.
    Endocr J; 1993 Jun 21; 40(3):363-72. PubMed ID: 7920890
    [Abstract] [Full Text] [Related]

  • 18. Constitutive activation of cyclic AMP but not phosphatidylinositol signaling caused by four mutations in the 6th transmembrane helix of the human thyrotropin receptor.
    Kosugi S, Shenker A, Mori T.
    FEBS Lett; 1994 Dec 19; 356(2-3):291-4. PubMed ID: 7805857
    [Abstract] [Full Text] [Related]

  • 19. Epitope-tagging of a functional thyrotropin receptor: detection of the native receptor on intact cells.
    Tanaka K, Nagayama Y, Yamasaki H, Hayashi H, Namba H, Yamashita S, Niwa M.
    Biochem Biophys Res Commun; 1996 Nov 01; 228(1):21-8. PubMed ID: 8912631
    [Abstract] [Full Text] [Related]

  • 20. Role of cysteine residues in the extracellular domain and exoplasmic loops of the transmembrane domain of the TSH receptor: effect of mutation to serine on TSH receptor activity and response to thyroid stimulating autoantibodies.
    Kosugi S, Ban T, Akamizu T, Kohn LD.
    Biochem Biophys Res Commun; 1992 Dec 30; 189(3):1754-62. PubMed ID: 1336379
    [Abstract] [Full Text] [Related]


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