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280 related items for PubMed ID: 8649346

  • 1. Point mutations of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid(A) receptor affecting modulation of the channel by ligands of the benzodiazepine binding site.
    Buhr A, Baur R, Malherbe P, Sigel E.
    Mol Pharmacol; 1996 Jun; 49(6):1080-4. PubMed ID: 8649346
    [Abstract] [Full Text] [Related]

  • 2. Pharmacology of the human gamma-aminobutyric acidA receptor alpha 4 subunit expressed in Xenopus laevis oocytes.
    Whittemore ER, Yang W, Drewe JA, Woodward RM.
    Mol Pharmacol; 1996 Nov; 50(5):1364-75. PubMed ID: 8913369
    [Abstract] [Full Text] [Related]

  • 3. Influence of recombinant gamma-aminobutyric acid-A receptor subunit composition on the action of allosteric modulators of gamma-aminobutyric acid-gated Cl- currents.
    Puia G, Vicini S, Seeburg PH, Costa E.
    Mol Pharmacol; 1991 Jun; 39(6):691-6. PubMed ID: 1646944
    [Abstract] [Full Text] [Related]

  • 4. The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors.
    Popik P, Kostakis E, Krawczyk M, Nowak G, Szewczyk B, Krieter P, Chen Z, Russek SJ, Gibbs TT, Farb DH, Skolnick P, Lippa AS, Basile AS.
    J Pharmacol Exp Ther; 2006 Dec; 319(3):1244-52. PubMed ID: 16971504
    [Abstract] [Full Text] [Related]

  • 5. Alterations of the benzodiazepine site of rat alpha 6 beta 2 gamma 2-GABAA receptor by replacement of several divergent amino-terminal regions with the alpha 1 counterparts.
    Im WB, Pregenzer JF, Binder JA, Alberts GL, Im HK.
    Br J Pharmacol; 1997 Feb; 120(4):559-64. PubMed ID: 9051290
    [Abstract] [Full Text] [Related]

  • 6. The agonist binding site of the gamma-aminobutyric acid type A channel is not formed by the extracellular cysteine loop.
    Amin J, Dickerson IM, Weiss DS.
    Mol Pharmacol; 1994 Feb; 45(2):317-23. PubMed ID: 7509443
    [Abstract] [Full Text] [Related]

  • 7. Functional comparison of the role of gamma subunits in recombinant human gamma-aminobutyric acidA/benzodiazepine receptors.
    Wafford KA, Bain CJ, Whiting PJ, Kemp JA.
    Mol Pharmacol; 1993 Aug; 44(2):437-42. PubMed ID: 8102787
    [Abstract] [Full Text] [Related]

  • 8. Potentiation of gamma-aminobutyric acid-induced chloride currents by various benzodiazepine site agonists with the alpha 1 gamma 2, beta 2 gamma 2 and alpha 1 beta 2 gamma 2 subtypes of cloned gamma-aminobutyric acid type A receptors.
    Im HK, Im WB, Hamilton BJ, Carter DB, Vonvoigtlander PF.
    Mol Pharmacol; 1993 Oct; 44(4):866-70. PubMed ID: 7901754
    [Abstract] [Full Text] [Related]

  • 9. Covalent modification of GABAA receptor isoforms by a diazepam analogue provides evidence for a novel benzodiazepine binding site that prevents modulation by these drugs.
    Baur R, Tan KR, Lüscher BP, Gonthier A, Goeldner M, Sigel E.
    J Neurochem; 2008 Sep; 106(6):2353-63. PubMed ID: 18643789
    [Abstract] [Full Text] [Related]

  • 10. Cloning of cDNAs encoding the human gamma-aminobutyric acid type A receptor alpha 6 subunit and characterization of the pharmacology of alpha 6-containing receptors.
    Hadingham KL, Garrett EM, Wafford KA, Bain C, Heavens RP, Sirinathsinghji DJ, Whiting PJ.
    Mol Pharmacol; 1996 Feb; 49(2):253-9. PubMed ID: 8632757
    [Abstract] [Full Text] [Related]

  • 11. Functional characterization of human gamma-aminobutyric acidA receptors containing the alpha 4 subunit.
    Wafford KA, Thompson SA, Thomas D, Sikela J, Wilcox AS, Whiting PJ.
    Mol Pharmacol; 1996 Sep; 50(3):670-8. PubMed ID: 8794909
    [Abstract] [Full Text] [Related]

  • 12. Pharmacological properties of GABAA receptors containing gamma1 subunits.
    Khom S, Baburin I, Timin EN, Hohaus A, Sieghart W, Hering S.
    Mol Pharmacol; 2006 Feb; 69(2):640-9. PubMed ID: 16272224
    [Abstract] [Full Text] [Related]

  • 13. Benzodiazepines affect channel opening of GABA A receptors induced by either agonist binding site.
    Baur R, Sigel E.
    Mol Pharmacol; 2005 Apr; 67(4):1005-8. PubMed ID: 15657366
    [Abstract] [Full Text] [Related]

  • 14. The alpha5(H105R) mutation impairs alpha5 selective binding properties by altered positioning of the alpha5 subunit in GABAA receptors containing two distinct types of alpha subunits.
    Balic E, Rudolph U, Fritschy JM, Mohler H, Benke D.
    J Neurochem; 2009 Jul; 110(1):244-54. PubMed ID: 19457072
    [Abstract] [Full Text] [Related]

  • 15. Differences in affinity and efficacy of benzodiazepine receptor ligands at recombinant gamma-aminobutyric acidA receptor subtypes.
    Wafford KA, Whiting PJ, Kemp JA.
    Mol Pharmacol; 1993 Feb; 43(2):240-4. PubMed ID: 8381510
    [Abstract] [Full Text] [Related]

  • 16. Properties of recombinant gamma-aminobutyric acid A receptor isoforms containing the alpha 5 subunit subtype.
    Burgard EC, Tietz EI, Neelands TR, Macdonald RL.
    Mol Pharmacol; 1996 Jul; 50(1):119-27. PubMed ID: 8700104
    [Abstract] [Full Text] [Related]

  • 17. Mutagenesis of the rat alpha1 subunit of the gamma-aminobutyric acid(A) receptor reveals the importance of residue 101 in determining the allosteric effects of benzodiazepine site ligands.
    Dunn SM, Davies M, Muntoni AL, Lambert JJ.
    Mol Pharmacol; 1999 Oct; 56(4):768-74. PubMed ID: 10496960
    [Abstract] [Full Text] [Related]

  • 18. Benzodiazepine-induced motor impairment linked to point mutation in cerebellar GABAA receptor.
    Korpi ER, Kleingoor C, Kettenmann H, Seeburg PH.
    Nature; 1993 Jan 28; 361(6410):356-9. PubMed ID: 7678923
    [Abstract] [Full Text] [Related]

  • 19. GABAA receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbital.
    Amin J, Weiss DS.
    Nature; 1993 Dec 09; 366(6455):565-9. PubMed ID: 7504783
    [Abstract] [Full Text] [Related]

  • 20. The interaction of general anaesthetics with recombinant GABAA and glycine receptors expressed in Xenopus laevis oocytes: a comparative study.
    Pistis M, Belelli D, Peters JA, Lambert JJ.
    Br J Pharmacol; 1997 Dec 09; 122(8):1707-19. PubMed ID: 9422818
    [Abstract] [Full Text] [Related]

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