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771 related items for PubMed ID: 8649786

  • 1. Differential changes of retinoid-X-receptor (RXR alpha) and its RAR alpha and PML-RAR alpha partners induced by retinoic acid and cAMP distinguish maturation sensitive and resistant t(15;17) promyelocytic leukemia NB4 cells.
    Duprez E, Lillehaug JR, Gaub MP, Lanotte M.
    Oncogene; 1996 Jun 06; 12(11):2443-50. PubMed ID: 8649786
    [Abstract] [Full Text] [Related]

  • 2. cAMP signalling is decisive for recovery of nuclear bodies (PODs) during maturation of RA-resistant t(15;17) promyelocytic leukemia NB4 cells expressing PML-RAR alpha.
    Duprez E, Lillehaug JR, Naoe T, Lanotte M.
    Oncogene; 1996 Jun 06; 12(11):2451-9. PubMed ID: 8649787
    [Abstract] [Full Text] [Related]

  • 3. Growth suppression of acute promyelocytic leukemia cells having increased expression of the non-rearranged alleles: RAR alpha or PML.
    Ahn MJ, Nason-Burchenal K, Moasser MM, Dmitrovsky E.
    Oncogene; 1995 Jun 15; 10(12):2307-14. PubMed ID: 7784078
    [Abstract] [Full Text] [Related]

  • 4. Common defects of different retinoic acid resistant promyelocytic leukemia cells are persistent telomerase activity and nuclear body disorganization.
    Nason-Burchenal K, Maerz W, Albanell J, Allopenna J, Martin P, Moore MA, Dmitrovsky E.
    Differentiation; 1997 Aug 15; 61(5):321-31. PubMed ID: 9342843
    [Abstract] [Full Text] [Related]

  • 5. Mutant AF-2 domain of PML-RARalpha in retinoic acid-resistant NB4 cells: differentiation induced by RA is triggered directly through PML-RARalpha and its down-regulation in acute promyelocytic leukemia.
    Kitamura K, Kiyoi H, Yoshida H, Saito H, Ohno R, Naoe T.
    Leukemia; 1997 Nov 15; 11(11):1950-6. PubMed ID: 9369431
    [Abstract] [Full Text] [Related]

  • 6. Distinct apoptotic responses in maturation sensitive and resistant t(15;17) acute promyelocytic leukemia NB4 cells. 9-cis retinoic acid induces apoptosis independent of maturation and Bcl-2 expression.
    Bruel A, Benoit G, De Nay D, Brown S, Lanotte M.
    Leukemia; 1995 Jul 15; 9(7):1173-84. PubMed ID: 7630193
    [Abstract] [Full Text] [Related]

  • 7. Retinoid-induced differentiation of acute promyelocytic leukemia involves PML-RARalpha-mediated increase of type II transglutaminase.
    Benedetti L, Grignani F, Scicchitano BM, Jetten AM, Diverio D, Lo Coco F, Avvisati G, Gambacorti-Passerini C, Adamo S, Levin AA, Pelicci PG, Nervi C.
    Blood; 1996 Mar 01; 87(5):1939-50. PubMed ID: 8634442
    [Abstract] [Full Text] [Related]

  • 8. UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia.
    Kitareewan S, Pitha-Rowe I, Sekula D, Lowrey CH, Nemeth MJ, Golub TR, Freemantle SJ, Dmitrovsky E.
    Proc Natl Acad Sci U S A; 2002 Mar 19; 99(6):3806-11. PubMed ID: 11891284
    [Abstract] [Full Text] [Related]

  • 9. Tyrosine kinase inhibitor STI571 potentiates the pharmacologic activity of retinoic acid in acute promyelocytic leukemia cells: effects on the degradation of RARalpha and PML-RARalpha.
    Gianni' M, Kalaç Y, Ponzanelli I, Rambaldi A, Terao M, Garattini E.
    Blood; 2001 May 15; 97(10):3234-43. PubMed ID: 11342454
    [Abstract] [Full Text] [Related]

  • 10. RXRα ligand Z-10 induces PML-RARα cleavage and APL cell apoptosis through disrupting PML-RARα/RXRα complex in a cAMP-independent manner.
    Xu L, Zeng Z, Zhang W, Ren G, Ling X, Huang F, Xie P, Su Y, Zhang XK, Zhou H.
    Oncotarget; 2017 Feb 14; 8(7):12311-12322. PubMed ID: 28129653
    [Abstract] [Full Text] [Related]

  • 11. Granulocytic differentiation of human NB4 promyelocytic leukemia cells induced by all-trans retinoic acid metabolites.
    Idres N, Benoît G, Flexor MA, Lanotte M, Chabot GG.
    Cancer Res; 2001 Jan 15; 61(2):700-5. PubMed ID: 11212271
    [Abstract] [Full Text] [Related]

  • 12. A retinoid-resistant acute promyelocytic leukemia subclone expresses a dominant negative PML-RAR alpha mutation.
    Shao W, Benedetti L, Lamph WW, Nervi C, Miller WH.
    Blood; 1997 Jun 15; 89(12):4282-9. PubMed ID: 9192750
    [Abstract] [Full Text] [Related]

  • 13. PML/RAR alpha+ U937 mutant and NB4 cell lines: retinoic acid restores the monocytic differentiation response to vitamin D3.
    Testa U, Grignani F, Barberi T, Fagioli M, Masciulli R, Ferrucci PF, Seripa D, Camagna A, Alcalay M, Pelicci PG.
    Cancer Res; 1994 Aug 15; 54(16):4508-15. PubMed ID: 7519122
    [Abstract] [Full Text] [Related]

  • 14. A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins.
    Zhong S, Delva L, Rachez C, Cenciarelli C, Gandini D, Zhang H, Kalantry S, Freedman LP, Pandolfi PP.
    Nat Genet; 1999 Nov 15; 23(3):287-95. PubMed ID: 10610177
    [Abstract] [Full Text] [Related]

  • 15. In acute promyelocytic leukemia NB4 cells, the synthetic retinoid CD437 induces contemporaneously apoptosis, a caspase-3-mediated degradation of PML/RARalpha protein and the PML retargeting on PML-nuclear bodies.
    Giannì M, de Thé H.
    Leukemia; 1999 May 15; 13(5):739-49. PubMed ID: 10374879
    [Abstract] [Full Text] [Related]

  • 16. Caspases mediate retinoic acid-induced degradation of the acute promyelocytic leukemia PML/RARalpha fusion protein.
    Nervi C, Ferrara FF, Fanelli M, Rippo MR, Tomassini B, Ferrucci PF, Ruthardt M, Gelmetti V, Gambacorti-Passerini C, Diverio D, Grignani F, Pelicci PG, Testi R.
    Blood; 1998 Oct 01; 92(7):2244-51. PubMed ID: 9746761
    [Abstract] [Full Text] [Related]

  • 17. Targeting of PML/RARalpha is lethal to retinoic acid-resistant promyelocytic leukemia cells.
    Nason-Burchenal K, Allopenna J, Bègue A, Stéhelin D, Dmitrovsky E, Martin P.
    Blood; 1998 Sep 01; 92(5):1758-67. PubMed ID: 9716606
    [Abstract] [Full Text] [Related]

  • 18. Interferon augments PML and PML/RAR alpha expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid-resistant promyelocytic cell line.
    Nason-Burchenal K, Gandini D, Botto M, Allopenna J, Seale JR, Cross NC, Goldman JM, Dmitrovsky E, Pandolfi PP.
    Blood; 1996 Nov 15; 88(10):3926-36. PubMed ID: 8916959
    [Abstract] [Full Text] [Related]

  • 19. Retinoic acid induces proteasome-dependent degradation of retinoic acid receptor alpha (RARalpha) and oncogenic RARalpha fusion proteins.
    Zhu J, Gianni M, Kopf E, Honoré N, Chelbi-Alix M, Koken M, Quignon F, Rochette-Egly C, de Thé H.
    Proc Natl Acad Sci U S A; 1999 Dec 21; 96(26):14807-12. PubMed ID: 10611294
    [Abstract] [Full Text] [Related]

  • 20. Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways.
    Dong S, Tweardy DJ.
    Blood; 2002 Apr 15; 99(8):2637-46. PubMed ID: 11929748
    [Abstract] [Full Text] [Related]

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