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Journal Abstract Search

223 related items for PubMed ID: 8654196

  • 1. Verlukast (MK-0679) conjugation with glutathione by rat liver and kidney cytosols and excretion in the bile.
    Nicoll-Griffith DA, Gupta N, Twa SP, Williams H, Trimble LA, Yergey JA.
    Drug Metab Dispos; 1995 Oct; 23(10):1085-93. PubMed ID: 8654196
    [Abstract] [Full Text] [Related]

  • 2. In vitro and in vivo biotransformations of the potent leukotriene D4 antagonist verlukast in the rat.
    Nicoll-Griffith D, Yergey J, Trimble L, Williams H, Rasori R, Zamboni R.
    Drug Metab Dispos; 1992 Oct; 20(3):383-9. PubMed ID: 1355712
    [Abstract] [Full Text] [Related]

  • 3. Characterization of verlukast metabolites arising from an epoxide intermediate produced with hepatic microsomes from beta-naphthoflavone-treated rodents (P-4501A1).
    Nicoll-Griffith DA, Chauret N, Yergey JA, Trimble LA, Favreau L, Zamboni R, Grossman SJ, Drey J, Herold E.
    Drug Metab Dispos; 1993 Oct; 21(5):861-7. PubMed ID: 7902249
    [Abstract] [Full Text] [Related]

  • 4. Conjugation of glutathione with a toxic metabolite of valproic acid, (E)-2-propyl-2,4-pentadienoic acid, catalyzed by rat hepatic glutathione-S-transferases.
    Tang W, Borel AG, Abbott FS.
    Drug Metab Dispos; 1996 Apr; 24(4):436-46. PubMed ID: 8801059
    [Abstract] [Full Text] [Related]

  • 5. Metabolism of hexafluoropropene. Evidence for bioactivation by glutathione conjugate formation in the kidney.
    Koob M, Dekant W.
    Drug Metab Dispos; 1990 Apr; 18(6):911-6. PubMed ID: 1981536
    [Abstract] [Full Text] [Related]

  • 6. The fate of diastereomeric glutathione conjugates of alpha-bromoisovalerylurea in blood in the rat in vivo and in the perfused liver. Stereoselectivity in biliary and urinary excretion.
    Polhuijs M, Meijer DK, Mulder GJ.
    J Pharmacol Exp Ther; 1991 Feb; 256(2):458-61. PubMed ID: 1993989
    [Abstract] [Full Text] [Related]

  • 7. Liquid chromatography/nuclear magnetic resonance spectroscopy and liquid chromatography/mass spectrometry identification of novel metabolites of the multidrug resistance modulator LY335979 in rat bile and human liver microsomal incubations.
    Ehlhardt WJ, Woodland JM, Baughman TM, Vandenbranden M, Wrighton SA, Kroin JS, Norman BH, Maple SR.
    Drug Metab Dispos; 1998 Jan; 26(1):42-51. PubMed ID: 9443851
    [Abstract] [Full Text] [Related]

  • 8. Identification in rat bile of glutathione conjugates of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether, a nephrotoxic degradate of the anesthetic agent sevoflurane.
    Jin L, Davis MR, Kharasch ED, Doss GA, Baillie TA.
    Chem Res Toxicol; 1996 Mar; 9(2):555-61. PubMed ID: 8839062
    [Abstract] [Full Text] [Related]

  • 9. CYP1A1 specificity of Verlukast epoxidation in mice, rats, rhesus monkeys, and humans.
    Grossman SJ, Herold EG, Drey JM, Alberts DW, Umbenhauer DR, Patrick DH, Nicoll-Griffith D, Chauret N, Yergey JA.
    Drug Metab Dispos; 1993 Mar; 21(6):1029-36. PubMed ID: 7905381
    [Abstract] [Full Text] [Related]

  • 10. alpha-Bromoisovalerylurea as model substrate for studies on pharmacokinetics of glutathione conjugation in the rat. II. Pharmacokinetics and stereoselectivity of metabolism and excretion in vivo and in the perfused liver.
    te Koppele JM, Dogterom P, Vermeulen NP, Meijer DK, van der Gen A, Mulder GJ.
    J Pharmacol Exp Ther; 1986 Dec; 239(3):905-14. PubMed ID: 3795049
    [Abstract] [Full Text] [Related]

  • 11. Glutathione conjugation and pharmacokinetics of 2-bromo-3-phenylpropionic acid in vitro and in the rat in vivo.
    Snel CA, Mahadevan S, Polhuijs M, Mulder GJ.
    Chirality; 1992 Dec; 4(7):407-14. PubMed ID: 1361150
    [Abstract] [Full Text] [Related]

  • 12. In vitro biotransformation and genotoxicity of the drinking water disinfection byproduct bromodichloromethane: DNA binding mediated by glutathione transferase theta 1-1.
    Ross MK, Pegram RA.
    Toxicol Appl Pharmacol; 2004 Mar 01; 195(2):166-81. PubMed ID: 14998683
    [Abstract] [Full Text] [Related]

  • 13. The metabolism and excretion of styrene oxide-glutathione conjugates in the rat and by isolated perfused liver, lung and kidney preparations.
    Steele JW, Yagen B, Hernandez O, Cox RH, Smith BR, Bend JR.
    J Pharmacol Exp Ther; 1981 Oct 01; 219(1):35-41. PubMed ID: 7288613
    [Abstract] [Full Text] [Related]

  • 14. Bimolecular glutathione conjugation kinetics of ethacrynic acid in rat liver: in vitro and perfusion studies.
    Tirona RG, Pang KS.
    J Pharmacol Exp Ther; 1999 Sep 01; 290(3):1230-41. PubMed ID: 10454499
    [Abstract] [Full Text] [Related]

  • 15. Glutathione conjugation of trichloroethylene in human liver and kidney: kinetics and individual variation.
    Lash LH, Lipscomb JC, Putt DA, Parker JC.
    Drug Metab Dispos; 1999 Mar 01; 27(3):351-9. PubMed ID: 10064565
    [Abstract] [Full Text] [Related]

  • 16. alpha-Bromoisovalerylurea as model substrate for studies on pharmacokinetics of glutathione conjugation in the rat. I. (Bio-) synthesis, analysis and identification of diastereomeric glutathione conjugates and mercapturates.
    te Koppele JM, van der Mark EJ, Olde Boerrigter JC, Brussee J, van der Gen A, van der Greef J, Mulder GJ.
    J Pharmacol Exp Ther; 1986 Dec 01; 239(3):898-904. PubMed ID: 3795048
    [Abstract] [Full Text] [Related]

  • 17. Detection and mechanisms of formation of S-(6-purinyl)glutathione and 6-mercaptopurine in rats given 6-chloropurine.
    Hwang IY, Elfarra AA.
    J Pharmacol Exp Ther; 1993 Jan 01; 264(1):41-6. PubMed ID: 8423540
    [Abstract] [Full Text] [Related]

  • 18. HPLC-NMR with severe column overloading: fast-track metabolite identification in urine and bile samples from rat and dog treated with [14C]-ZD6126.
    Lenz EM, D'Souza RA, Jordan AC, King CD, Smith SM, Phillips PJ, McCormick AD, Roberts DW.
    J Pharm Biomed Anal; 2007 Feb 19; 43(3):1065-77. PubMed ID: 17030109
    [Abstract] [Full Text] [Related]

  • 19. Characterization and formation of the glutathione conjugate of clofibric acid.
    Shore LJ, Fenselau C, King AR, Dickinson RG.
    Drug Metab Dispos; 1995 Jan 19; 23(1):119-23. PubMed ID: 7720514
    [Abstract] [Full Text] [Related]

  • 20. Lack of glutathione conjugation of melphalan in the isolated in situ liver perfusion in humans.
    Vahrmeijer AL, Snel CA, Steenvoorden DP, Beijnen JH, Pang KS, Schutrups J, Tirona R, Keizer HJ, van Dierendonck JH, van de Velde CJ, Mulder GJ.
    Cancer Res; 1996 Oct 15; 56(20):4709-14. PubMed ID: 8840988
    [Abstract] [Full Text] [Related]

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