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Journal Abstract Search

146 related items for PubMed ID: 8654696

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  • 4. Enzymes of the trypanothione metabolism as targets for antitrypanosomal drug development.
    Schmidt A, Krauth-Siegel RL.
    Curr Top Med Chem; 2002 Nov; 2(11):1239-59. PubMed ID: 12171583
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  • 5. Trypanothione metabolism and rational approaches to drug design.
    Fairlamb AH.
    Biochem Soc Trans; 1990 Oct; 18(5):717-20. PubMed ID: 2083656
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  • 6. The synthesis and inhibitory activity of dethiotrypanothione and analogues against trypanothione reductase.
    Czechowicz JA, Wilhelm AK, Spalding MD, Larson AM, Engel LK, Alberg DG.
    J Org Chem; 2007 May 11; 72(10):3689-93. PubMed ID: 17439174
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  • 8. Recent Advancement in the Search of Innovative Antiprotozoal Agents Targeting Trypanothione Metabolism.
    Saccoliti F, Di Santo R, Costi R.
    ChemMedChem; 2020 Dec 15; 15(24):2420-2435. PubMed ID: 32805075
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  • 9. The therapeutic potential of inhibitors of the trypanothione cycle.
    D'Silva C, Daunes S.
    Expert Opin Investig Drugs; 2002 Feb 15; 11(2):217-31. PubMed ID: 11829713
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  • 10. Design, synthesis and biological evaluation of new potent 5-nitrofuryl derivatives as anti-Trypanosoma cruzi agents. Studies of trypanothione binding site of trypanothione reductase as target for rational design.
    Aguirre G, Cabrera E, Cerecetto H, Di Maio R, González M, Seoane G, Duffaut A, Denicola A, Gil MJ, Martínez-Merino V.
    Eur J Med Chem; 2004 May 15; 39(5):421-31. PubMed ID: 15110968
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  • 11. The Achilles' heel of trypanosomatids: trypanothione-mediated hydroperoxide metabolism.
    Flohé L.
    Biofactors; 1998 May 15; 8(1-2):87-91. PubMed ID: 9699014
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  • 12. Identification of potential trypanothione reductase inhibitors among commercially available β-carboline derivatives using chemical space, lead-like and drug-like filters, pharmacophore models and molecular docking.
    Rodríguez-Becerra J, Cáceres-Jensen L, Hernández-Ramos J, Barrientos L.
    Mol Divers; 2017 Aug 15; 21(3):697-711. PubMed ID: 28656524
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  • 13. Polyamines with N-(3-phenylpropyl) substituents are effective competitive inhibitors of trypanothione reductase and trypanocidal agents.
    Li Z, Fennie MW, Ganem B, Hancock MT, Kobaslija M, Rattendi D, Bacchi CJ, O'Sullivan MC.
    Bioorg Med Chem Lett; 2001 Jan 22; 11(2):251-4. PubMed ID: 11206471
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  • 14. Optimising inhibitors of trypanothione reductase using solid-phase chemistry.
    Chitkul B, Bradley M.
    Bioorg Med Chem Lett; 2000 Oct 16; 10(20):2367-9. PubMed ID: 11055357
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  • 15. Trypanothione reductase: a target protein for a combined in vitro and in silico screening approach.
    Beig M, Oellien F, Garoff L, Noack S, Krauth-Siegel RL, Selzer PM.
    PLoS Negl Trop Dis; 2015 Oct 16; 9(6):e0003773. PubMed ID: 26042772
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  • 16. Polyamine derivatives as inhibitors of trypanothione reductase and assessment of their trypanocidal activities.
    O'Sullivan MC, Zhou Q, Li Z, Durham TB, Rattendi D, Lane S, Bacchi CJ.
    Bioorg Med Chem; 1997 Dec 16; 5(12):2145-55. PubMed ID: 9459012
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  • 17. Docking and molecular dynamics studies at trypanothione reductase and glutathione reductase active sites.
    Iribarne F, Paulino M, Aguilera S, Murphy M, Tapia O.
    J Mol Model; 2002 May 16; 8(5):173-83. PubMed ID: 12111385
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  • 18. Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents.
    Augustyns K, Amssoms K, Yamani A, Rajan PK, Haemers A.
    Curr Pharm Des; 2001 Aug 16; 7(12):1117-41. PubMed ID: 11472257
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  • 19. Structural analysis and molecular docking of trypanocidal aryloxy-quinones in trypanothione and glutathione reductases: a comparison with biochemical data.
    Vera B, Vázquez K, Mascayano C, Tapia RA, Espinosa V, Soto-Delgado J, Salas CO, Paulino M.
    J Biomol Struct Dyn; 2017 Jun 16; 35(8):1785-1803. PubMed ID: 27232454
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  • 20. Targeting trypanothione metabolism in trypanosomatid human parasites.
    Olin-Sandoval V, Moreno-Sánchez R, Saavedra E.
    Curr Drug Targets; 2010 Dec 16; 11(12):1614-30. PubMed ID: 20735352
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