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88 related items for PubMed ID: 8661341

  • 1. Biotransformation of the MPTP analog trans-1-methyl-4-[4-dimethylaminophenylethenyl]-1,2,3,6-tetra- hydropyridine to a fluorescent pyridinium metabolite by intact neuroblastoma cells.
    Song X, Ehrich M, Flaherty D, Wang YX, Castagnoli N.
    Toxicol Appl Pharmacol; 1996 Apr; 137(2):163-72. PubMed ID: 8661341
    [Abstract] [Full Text] [Related]

  • 2. R-(-)-Deprenyl inhibits monocytic THP-1 cell neurotoxicity independently of monoamine oxidase inhibition.
    Klegeris A, McGeer PL.
    Exp Neurol; 2000 Dec; 166(2):458-64. PubMed ID: 11085911
    [Abstract] [Full Text] [Related]

  • 3. Pharmacological properties of the MPTP analog trans-1-methyl-4-[4-dimethylaminophenylethenyl]-1,2,3,6-tetrahydropyridine and its pyridinium metabolite in mouse brain synaptosomes: a potential visual marker for substrates of MPTP-induced neurotoxicity.
    Klein BG, Kirby ML, Freeborn ER, Bloomquist JR.
    Prog Neuropsychopharmacol Biol Psychiatry; 2001 Apr; 25(3):591-608. PubMed ID: 11370999
    [Abstract] [Full Text] [Related]

  • 4. Neurotoxicity studies with the monoamine oxidase B substrate 1-methyl-3-phenyl-3-pyrroline.
    Ogunrombi MO, Malan SF, Terre'Blanche G, Castagnoli K, Castagnoli N, Bergh JJ, Petzer JP.
    Life Sci; 2007 Jul 19; 81(6):458-67. PubMed ID: 17655878
    [Abstract] [Full Text] [Related]

  • 5. Development of fluorinated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs with potent nigrostriatal toxicity for potential use in positron emission tomography studies.
    Harik SI, Riachi NJ, Hritz MA, Berridge MS, Sayre LM.
    J Pharmacol Exp Ther; 1993 Aug 19; 266(2):790-5. PubMed ID: 8355208
    [Abstract] [Full Text] [Related]

  • 6. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine- and 1-methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine-induced toxicity in PC12 cells: role of monoamine oxidase A.
    Basma AN, Heikkila RE, Nicklas WJ, Giovanni A, Geller HM.
    J Neurochem; 1990 Sep 19; 55(3):870-7. PubMed ID: 2384758
    [Abstract] [Full Text] [Related]

  • 7. A reactive metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is formed in rat brain in vitro by type B monoamine oxidase.
    Corsini GU, Pintus S, Bocchetta A, Piccardi MP, Del Zompo M.
    J Pharmacol Exp Ther; 1986 Aug 19; 238(2):648-52. PubMed ID: 3488394
    [Abstract] [Full Text] [Related]

  • 8. D-deprenyl protects nigrostriatal neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity.
    Muralikrishnan D, Samantaray S, Mohanakumar KP.
    Synapse; 2003 Oct 19; 50(1):7-13. PubMed ID: 12872288
    [Abstract] [Full Text] [Related]

  • 9. Toxicity of MPTP and structural analogs in clonal cell lines of neuronal origin expressing B type monoamine oxidase activity.
    Buckman TD.
    Mol Chem Neuropathol; 1991 Oct 19; 15(2):87-102. PubMed ID: 1776993
    [Abstract] [Full Text] [Related]

  • 10. Species-dependent differences in monoamine oxidase A and B-catalyzed oxidation of various C4 substituted 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridinyl derivatives.
    Inoue H, Castagnoli K, Van Der Schyf C, Mabic S, Igarashi K, Castagnoli N.
    J Pharmacol Exp Ther; 1999 Nov 19; 291(2):856-64. PubMed ID: 10525109
    [Abstract] [Full Text] [Related]

  • 11. CEP-1347/KT-7515, an inhibitor of c-jun N-terminal kinase activation, attenuates the 1-methyl-4-phenyl tetrahydropyridine-mediated loss of nigrostriatal dopaminergic neurons In vivo.
    Saporito MS, Brown EM, Miller MS, Carswell S.
    J Pharmacol Exp Ther; 1999 Feb 19; 288(2):421-7. PubMed ID: 9918541
    [Abstract] [Full Text] [Related]

  • 12. (-)-Deprenyl protection of 1-methyl-4 phenylpyridium ion (MPP+)-induced apoptosis independent of MAO-B inhibition.
    Le W, Jankovic J, Xie W, Kong R, Appel SH.
    Neurosci Lett; 1997 Mar 21; 224(3):197-200. PubMed ID: 9131670
    [Abstract] [Full Text] [Related]

  • 13. Comparative aromatic hydroxylation and N-demethylation of MPTP neurotoxin and its analogs, N-methylated beta-carboline and isoquinoline alkaloids, by human cytochrome P450 2D6.
    Herraiz T, Guillén H, Arán VJ, Idle JR, Gonzalez FJ.
    Toxicol Appl Pharmacol; 2006 Nov 01; 216(3):387-98. PubMed ID: 16870220
    [Abstract] [Full Text] [Related]

  • 14. Measurement of mitochondrial respiration in permeabilized murine neuroblastoma (N-2alpha) cells, a simple and rapid in situ assay to investigate mitochondrial toxins.
    Steyn SJ, Pieterse DJ, Mienie LJ, Van der Schyf CJ.
    J Biochem Biophys Methods; 2005 Jan 31; 62(1):25-40. PubMed ID: 15656941
    [Abstract] [Full Text] [Related]

  • 15. Deuterium isotope effects for the oxidation of 1-methyl-3-phenyl-3-pyrrolinyl analogues by monoamine oxidase B.
    Pretorius A, Ogunrombi MO, Terre'blanche G, Castagnoli N, Bergh JJ, Petzer JP.
    Bioorg Med Chem; 2008 Oct 01; 16(19):8813-7. PubMed ID: 18799315
    [Abstract] [Full Text] [Related]

  • 16. Cytotoxic effects of MPTP on SH-SY5Y human neuroblastoma cells.
    Song X, Perkins S, Jortner BS, Ehrich M.
    Neurotoxicology; 1997 Oct 01; 18(2):341-53. PubMed ID: 9291484
    [Abstract] [Full Text] [Related]

  • 17. Iron-mediated bioactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in glial cultures.
    Di Monte DA, Schipper HM, Hetts S, Langston JW.
    Glia; 1995 Oct 01; 15(2):203-6. PubMed ID: 8567072
    [Abstract] [Full Text] [Related]

  • 18. Type A monoamine oxidase is the target of an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol, leading to apoptosis in SH-SY5Y cells.
    Yi H, Akao Y, Maruyama W, Chen K, Shih J, Naoi M.
    J Neurochem; 2006 Jan 01; 96(2):541-9. PubMed ID: 16336631
    [Abstract] [Full Text] [Related]

  • 19. Involvement of hepatic aldehyde oxidase in conversion of 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+) to 1-methyl-4-phenyl-5,6-dihydro-2-pyridone.
    Yoshihara S, Ohta S.
    Arch Biochem Biophys; 1998 Dec 01; 360(1):93-8. PubMed ID: 9826433
    [Abstract] [Full Text] [Related]

  • 20. R(-)-deprenyl potentiates dopamine-induced cytotoxicity toward catecholaminergic neuroblastoma SH-SY5Y cells.
    Lai CT, Yu PH.
    Toxicol Appl Pharmacol; 1997 Jan 01; 142(1):186-91. PubMed ID: 9007048
    [Abstract] [Full Text] [Related]

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