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149 related items for PubMed ID: 8661342

  • 1. Sex differences in rat hepatic cytolethality of the protein kinase C inhibitor safingol: role of biotransformation.
    Carfagna MA, Young KM, Susick RL.
    Toxicol Appl Pharmacol; 1996 Apr; 137(2):173-81. PubMed ID: 8661342
    [Abstract] [Full Text] [Related]

  • 2. Furan-induced cytolethality in isolated rat hepatocytes: correspondence with in vivo dosimetry.
    Carfagna MA, Held SD, Kedderis GL.
    Toxicol Appl Pharmacol; 1993 Dec; 123(2):265-73. PubMed ID: 8248933
    [Abstract] [Full Text] [Related]

  • 3. Toxicity of the protein kinase C inhibitor safingol administered alone and in combination with chemotherapeutic agents.
    Kedderis LB, Bozigian HP, Kleeman JM, Hall RL, Palmer TE, Harrison SD, Susick RL.
    Fundam Appl Toxicol; 1995 May; 25(2):201-17. PubMed ID: 7665004
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  • 4. Safingol toxicology after oral administration to TRAMP mice: demonstration of safingol uptake and metabolism by N-acylation and N-methylation.
    Morales PR, Dillehay DL, Moody SJ, Pallas DC, Pruett S, Allgood JC, Symolon H, Merrill AH.
    Drug Chem Toxicol; 2007 May; 30(3):197-216. PubMed ID: 17613006
    [Abstract] [Full Text] [Related]

  • 5. Chloroform-induced cytolethality in freshly isolated male B6C3F1 mouse and F-344 rat hepatocytes.
    Ammann P, Laethem CL, Kedderis GL.
    Toxicol Appl Pharmacol; 1998 Apr; 149(2):217-25. PubMed ID: 9571991
    [Abstract] [Full Text] [Related]

  • 6. Enalapril hepatotoxicity in the rat. Effects of modulators of cytochrome P450 and glutathione.
    Jurima-Romet M, Huang HS.
    Biochem Pharmacol; 1992 Nov 03; 44(9):1803-10. PubMed ID: 1449535
    [Abstract] [Full Text] [Related]

  • 7. Furan-mediated uncoupling of hepatic oxidative phosphorylation in Fischer-344 rats: an early event in cell death.
    Mugford CA, Carfagna MA, Kedderis GL.
    Toxicol Appl Pharmacol; 1997 May 03; 144(1):1-11. PubMed ID: 9169064
    [Abstract] [Full Text] [Related]

  • 8. A pilot clinical/pharmacological study of the protein kinase C-specific inhibitor safingol alone and in combination with doxorubicin.
    Schwartz GK, Ward D, Saltz L, Casper ES, Spiess T, Mullen E, Woodworth J, Venuti R, Zervos P, Storniolo AM, Kelsen DP.
    Clin Cancer Res; 1997 Apr 03; 3(4):537-43. PubMed ID: 9815717
    [Abstract] [Full Text] [Related]

  • 9. Potentiation of apoptosis by treatment with the protein kinase C-specific inhibitor safingol in mitomycin C-treated gastric cancer cells.
    Schwartz GK, Haimovitz-Friedman A, Dhupar SK, Ehleiter D, Maslak P, Lai L, Loganzo F, Kelsen DP, Fuks Z, Albino AP.
    J Natl Cancer Inst; 1995 Sep 20; 87(18):1394-9. PubMed ID: 7658500
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  • 12. Hepatic microsomal enzyme induction, beta-oxidation, and cell proliferation following administration of clofibrate, gemfibrozil, or bezafibrate in the CD rat.
    Amacher DE, Beck R, Schomaker SJ, Kenny CV.
    Toxicol Appl Pharmacol; 1997 Jan 20; 142(1):143-50. PubMed ID: 9007043
    [Abstract] [Full Text] [Related]

  • 13. Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway.
    Coward J, Ambrosini G, Musi E, Truman JP, Haimovitz-Friedman A, Allegood JC, Wang E, Merrill AH, Schwartz GK.
    Autophagy; 2009 Feb 20; 5(2):184-93. PubMed ID: 19098447
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  • 16. Effect of enzyme induction on Sandimmun (cyclosporin A) biotransformation and hepatotoxicity in cultured rat hepatocytes and in vivo.
    Bouis P, Brouillard JF, Fischer V, Donatsch P, Boelsterli UA.
    Biochem Pharmacol; 1990 Jan 15; 39(2):257-66. PubMed ID: 2105730
    [Abstract] [Full Text] [Related]

  • 17. Crucial role of cytochrome P450 in hepatotoxicity induced by 2,3-dimethoxy-1,4-naphthoquinone in rats.
    Ishihara Y, Ishii S, Sakai Y, Yamamura N, Onishi Y, Shimamoto N.
    J Appl Toxicol; 2011 Mar 15; 31(2):173-8. PubMed ID: 20803752
    [Abstract] [Full Text] [Related]

  • 18. Toxicity of the antiandrogen flutamide in isolated rat hepatocytes.
    Fau D, Eugene D, Berson A, Letteron P, Fromenty B, Fisch C, Pessayre D.
    J Pharmacol Exp Ther; 1994 Jun 15; 269(3):954-62. PubMed ID: 8014883
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  • 19. NTP technical report on the toxicity and metabolism studies of chloral hydrate (CAS No. 302-17-0). Administered by gavage to F344/N rats and B6C3F1 mice.
    Beland FA.
    Toxic Rep Ser; 1999 Aug 15; (59):1-66, A1-E7. PubMed ID: 11803702
    [Abstract] [Full Text] [Related]

  • 20. Prediction of furan pharmacokinetics from hepatocyte studies: comparison of bioactivation and hepatic dosimetry in rats, mice, and humans.
    Kedderis GL, Held SD.
    Toxicol Appl Pharmacol; 1996 Sep 15; 140(1):124-30. PubMed ID: 8806878
    [Abstract] [Full Text] [Related]

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