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139 related items for PubMed ID: 8662659

  • 1. Protection by transfected rat or human class 3 aldehyde dehydrogenase against the cytotoxic effects of oxazaphosphorine alkylating agents in hamster V79 cell lines. Demonstration of aldophosphamide metabolism by the human cytosolic class 3 isozyme.
    Bunting KD, Townsend AJ.
    J Biol Chem; 1996 May 17; 271(20):11891-6. PubMed ID: 8662659
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  • 2. De novo expression of transfected human class 1 aldehyde dehydrogenase (ALDH) causes resistance to oxazaphosphorine anti-cancer alkylating agents in hamster V79 cell lines. Elevated class 1 ALDH activity is closely correlated with reduction in DNA interstrand cross-linking and lethality.
    Bunting KD, Townsend AJ.
    J Biol Chem; 1996 May 17; 271(20):11884-90. PubMed ID: 8662658
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  • 3. Oxazaphosphorine-specific resistance in human MCF-7 breast carcinoma cell lines expressing transfected rat class 3 aldehyde dehydrogenase.
    Bunting KD, Lindahl R, Townsend AJ.
    J Biol Chem; 1994 Sep 16; 269(37):23197-203. PubMed ID: 8083225
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  • 4. Dependence of aldehyde dehydrogenase-mediated oxazaphosphorine resistance on soluble thiols: importance of thiol interactions with the secondary metabolite acrolein.
    Bunting KD, Townsend AJ.
    Biochem Pharmacol; 1998 Jul 01; 56(1):31-9. PubMed ID: 9698086
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  • 12. Aldehyde dehydrogenase activity as the basis for the relative insensitivity of murine pluripotent hematopoietic stem cells to oxazaphosphorines.
    Kohn FR, Sladek NE.
    Biochem Pharmacol; 1985 Oct 01; 34(19):3465-71. PubMed ID: 2996550
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  • 13. Identification of human liver aldehyde dehydrogenases that catalyze the oxidation of aldophosphamide and retinaldehyde.
    Dockham PA, Lee MO, Sladek NE.
    Biochem Pharmacol; 1992 Jun 09; 43(11):2453-69. PubMed ID: 1610409
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  • 14. Effect of aldehyde dehydrogenase inhibitors on the ex vivo sensitivity of human multipotent and committed hematopoietic progenitor cells and malignant blood cells to oxazaphosphorines.
    Kohn FR, Landkamer GJ, Manthey CL, Ramsay NK, Sladek NE.
    Cancer Res; 1987 Jun 15; 47(12):3180-5. PubMed ID: 3034402
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  • 15. Selective protection by stably transfected human ALDH3A1 (but not human ALDH1A1) against toxicity of aliphatic aldehydes in V79 cells.
    Townsend AJ, Leone-Kabler S, Haynes RL, Wu Y, Szweda L, Bunting KD.
    Chem Biol Interact; 2001 Jan 30; 130-132(1-3):261-73. PubMed ID: 11306050
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  • 16. Effects of aldehyde dehydrogenase inhibitors on the ex vivo sensitivity of murine late spleen colony-forming cells (day-12 CFU-S) and hematopoietic repopulating cells to mafosfamide (ASTA Z 7557).
    Kohn FR, Sladek NE.
    Biochem Pharmacol; 1987 Sep 01; 36(17):2805-11. PubMed ID: 2820422
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  • 20. Overexpression of the human aldehyde dehydrogenase class I results in increased resistance to 4-hydroperoxycyclophosphamide.
    Moreb J, Schweder M, Suresh A, Zucali JR.
    Cancer Gene Ther; 1996 Sep 01; 3(1):24-30. PubMed ID: 8785707
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