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Journal Abstract Search

350 related items for PubMed ID: 8676343

  • 1. Hypoxia-selective antitumor agents. 12. Nitrobenzyl quaternary salts as bioreductive prodrugs of the alkylating agent mechlorethamine.
    Tercel M, Wilson WR, Anderson RF, Denny WA.
    J Med Chem; 1996 Mar 01; 39(5):1084-94. PubMed ID: 8676343
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  • 2. Hypoxia-selective antitumor agents. 14. Synthesis and hypoxic cell cytotoxicity of regioisomers of the hypoxia-selective cytotoxin 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide.
    Palmer BD, Wilson WR, Anderson RF, Boyd M, Denny WA.
    J Med Chem; 1996 Jun 21; 39(13):2518-28. PubMed ID: 8691449
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  • 3. Nitrobenzyl mustard quaternary salts: a new class of hypoxia-selective cytotoxins capable of releasing diffusible cytotoxins on bioreduction.
    Denny WA, Wilson WR, Tercel M, Van Zijl P, Pullen SM.
    Int J Radiat Oncol Biol Phys; 1994 May 15; 29(2):317-21. PubMed ID: 8195026
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  • 5. Nitroimidazole-based "extruded mustards' designed as reductively activated hypoxia-selective cytotoxins.
    Hay MP, Denny WA, Wilson WR.
    Anticancer Drug Des; 1996 Jul 15; 11(5):383-402. PubMed ID: 8765531
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  • 7. Hypoxia-selective antitumor agents. 5. Synthesis of water-soluble nitroaniline mustards with selective cytotoxicity for hypoxic mammalian cells.
    Palmer BD, Wilson WR, Cliffe S, Denny WA.
    J Med Chem; 1992 Aug 21; 35(17):3214-22. PubMed ID: 1507207
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  • 10. Hypoxia-selective antitumor agents. 3. Relationships between structure and cytotoxicity against cultured tumor cells for substituted N,N-bis(2-chloroethyl)anilines.
    Palmer BD, Wilson WR, Pullen SM, Denny WA.
    J Med Chem; 1990 Jan 21; 33(1):112-21. PubMed ID: 2296009
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  • 11. Optimization of alkylating agent prodrugs derived from phenol and aniline mustards: a new clinical candidate prodrug (ZD2767) for antibody-directed enzyme prodrug therapy (ADEPT).
    Springer CJ, Dowell R, Burke PJ, Hadley E, Davis DH, Blakey DC, Melton RG, Niculescu-Duvaz I.
    J Med Chem; 1995 Dec 22; 38(26):5051-65. PubMed ID: 8544182
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  • 12. Hypoxia-selective antitumor agents. 8. Bis(nitroimidazolyl)alkanecarboxamides: a new class of hypoxia-selective cytotoxins and hypoxic cell radiosensitisers.
    Hay MP, Wilson WR, Moselen JW, Palmer BD, Denny WA.
    J Med Chem; 1994 Feb 04; 37(3):381-91. PubMed ID: 8308864
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  • 13. Self-immolative nitrogen mustard prodrugs for suicide gene therapy.
    Niculescu-Duvaz D, Niculescu-Duvaz I, Friedlos F, Martin J, Spooner R, Davies L, Marais R, Springer CJ.
    J Med Chem; 1998 Dec 17; 41(26):5297-309. PubMed ID: 9857097
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  • 14. Hypoxia-selective antitumor agents. 9. Structure-activity relationships for hypoxia-selective cytotoxicity among analogues of 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide.
    Palmer BD, Wilson WR, Atwell GJ, Schultz D, Xu XZ, Denny WA.
    J Med Chem; 1994 Jul 08; 37(14):2175-84. PubMed ID: 8035424
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  • 15. Reductive chemistry of the novel hypoxia-selective cytotoxin 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide.
    Palmer BD, van Zijl P, Denny WA, Wilson WR.
    J Med Chem; 1995 Mar 31; 38(7):1229-41. PubMed ID: 7707325
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  • 18. Structure-activity relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine.
    Hay MP, Gamage SA, Kovacs MS, Pruijn FB, Anderson RF, Patterson AV, Wilson WR, Brown JM, Denny WA.
    J Med Chem; 2003 Jan 02; 46(1):169-82. PubMed ID: 12502371
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  • 20. A novel design strategy for stable metal complexes of nitrogen mustards as bioreductive prodrugs.
    Parker LL, Lacy SM, Farrugia LJ, Evans C, Robins DJ, O'Hare CC, Hartley JA, Jaffar M, Stratford IJ.
    J Med Chem; 2004 Nov 04; 47(23):5683-9. PubMed ID: 15509167
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