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Journal Abstract Search

350 related items for PubMed ID: 8676343

  • 21. Synthesis and structure-activity relationships for 2,4-dinitrobenzamide-5-mustards as prodrugs for the Escherichia coli nfsB nitroreductase in gene therapy.
    Atwell GJ, Yang S, Pruijn FB, Pullen SM, Hogg A, Patterson AV, Wilson WR, Denny WA.
    J Med Chem; 2007 Mar 22; 50(6):1197-212. PubMed ID: 17326614
    [Abstract] [Full Text] [Related]

  • 22. Hypoxia-selective antitumor agents. 10. bis(nitroimidazoles) and related Bis(nitroheterocycles): development of derivatives with higher rates of metabolic activation under hypoxia and improved aqueous solubility.
    Hay MP, Lee HH, Wilson WR, Roberts PB, Denny WA.
    J Med Chem; 1995 May 26; 38(11):1928-41. PubMed ID: 7783125
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  • 23. Nitracrine N-oxides: effects of variations in the nature of the side chain N-oxide on hypoxia-selective cytotoxicity.
    Lee HH, Wilson WR, Denny WA.
    Anticancer Drug Des; 1999 Dec 26; 14(6):487-97. PubMed ID: 10834270
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  • 24. Structure-activity relationships for 4-nitrobenzyl carbamates of 5-aminobenz[e]indoline minor groove alkylating agents as prodrugs for GDEPT in conjunction with E. coli nitroreductase.
    Hay MP, Atwell GJ, Wilson WR, Pullen SM, Denny WA.
    J Med Chem; 2003 Jun 05; 46(12):2456-66. PubMed ID: 12773049
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  • 25. Synthesis and evaluation of nitroheterocyclic phosphoramidates as hypoxia-selective alkylating agents.
    Borch RF, Liu J, Schmidt JP, Marakovits JT, Joswig C, Gipp JJ, Mulcahy RT.
    J Med Chem; 2000 Jun 01; 43(11):2258-65. PubMed ID: 10841804
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  • 26. Synthesis and evaluation of nitroheterocyclic carbamate prodrugs for use with nitroreductase-mediated gene-directed enzyme prodrug therapy.
    Hay MP, Anderson RF, Ferry DM, Wilson WR, Denny WA.
    J Med Chem; 2003 Dec 04; 46(25):5533-45. PubMed ID: 14640560
    [Abstract] [Full Text] [Related]

  • 27. Sulfoxide-containing aromatic nitrogen mustards as hypoxia-directed bioreductive cytotoxins.
    Sun ZY, Botros E, Su AD, Kim Y, Wang E, Baturay NZ, Kwon CH.
    J Med Chem; 2000 Nov 02; 43(22):4160-8. PubMed ID: 11063612
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  • 28. Bystander effects of bioreductive drugs: potential for exploiting pathological tumor hypoxia with dinitrobenzamide mustards.
    Wilson WR, Hicks KO, Pullen SM, Ferry DM, Helsby NA, Patterson AV.
    Radiat Res; 2007 Jun 02; 167(6):625-36. PubMed ID: 17523848
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  • 29. The effect of functional groups on reduction and activation of quinone bioreductive agents by DT-diaphorase.
    Fourie J, Oleschuk CJ, Guziec F, Guziec L, Fiterman DJ, Monterrosa C, Begleiter A.
    Cancer Chemother Pharmacol; 2002 Feb 02; 49(2):101-10. PubMed ID: 11862423
    [Abstract] [Full Text] [Related]

  • 30. Effect of nitroreduction on the alkylating reactivity and cytotoxicity of the 2,4-dinitrobenzamide-5-aziridine CB 1954 and the corresponding nitrogen mustard SN 23862: distinct mechanisms of bioreductive activation.
    Helsby NA, Wheeler SJ, Pruijn FB, Palmer BD, Yang S, Denny WA, Wilson WR.
    Chem Res Toxicol; 2003 Apr 02; 16(4):469-78. PubMed ID: 12703963
    [Abstract] [Full Text] [Related]

  • 31. Synthesis of 1-substituted 3-(chloromethyl)-6-aminoindoline (6-amino-seco-CI) DNA minor groove alkylating agents and structure-activity relationships for their cytotoxicity.
    Milbank JB, Tercel M, Atwell GJ, Wilson WR, Hogg A, Denny WA.
    J Med Chem; 1999 Feb 25; 42(4):649-58. PubMed ID: 10052972
    [Abstract] [Full Text] [Related]

  • 32. Hypoxia-selective antitumor agents. 15. Modification of rate of nitroreduction and extent of lysosomal uptake by polysubstitution of 4-(alkylamino)-5-nitroquinoline bioreductive drugs.
    Siim BG, Atwell GJ, Anderson RF, Wardman P, Pullen SM, Wilson WR, Denny WA.
    J Med Chem; 1997 Apr 25; 40(9):1381-90. PubMed ID: 9135035
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  • 33. Nitro analogues of chlorambucil as potential hypoxia-selective anti-tumour drugs.
    Palmer BD, Wilson WR, Denny WA.
    Anticancer Drug Des; 1990 Nov 25; 5(4):337-49. PubMed ID: 2291774
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  • 34. Toward hypoxia-selective DNA-alkylating agents built by grafting nitrogen mustards onto the bioreductively activated, hypoxia-selective DNA-oxidizing agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
    Johnson KM, Parsons ZD, Barnes CL, Gates KS.
    J Org Chem; 2014 Aug 15; 79(16):7520-31. PubMed ID: 25029663
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  • 35. Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs.
    Hu L, Wu X, Han J, Chen L, Vass SO, Browne P, Hall BS, Bot C, Gobalakrishnapillai V, Searle PF, Knox RJ, Wilkinson SR.
    Bioorg Med Chem Lett; 2011 Jul 01; 21(13):3986-91. PubMed ID: 21620697
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  • 36. The effect of sulfonate leaving groups on the hypoxia-selective toxicity of nitro analogs of the duocarmycins.
    Ashoorzadeh A, Atwell GJ, Pruijn FB, Wilson WR, Tercel M, Denny WA, Stevenson RJ.
    Bioorg Med Chem; 2011 Aug 15; 19(16):4851-60. PubMed ID: 21767954
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  • 37. 5-Amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indoles: relationships between structure and cytotoxicity for analogues bearing different DNA minor groove binding subunits.
    Atwell GJ, Milbank JJ, Wilson WR, Hogg A, Denny WA.
    J Med Chem; 1999 Aug 26; 42(17):3400-11. PubMed ID: 10464026
    [Abstract] [Full Text] [Related]

  • 38. Design, synthesis and evaluation of targeted hypoxia-activated prodrugs applied to chondrosarcoma chemotherapy.
    Gerard Y, Voissière A, Peyrode C, Galmier MJ, Maubert E, Ghedira D, Tarrit S, Gaumet V, Canitrot D, Miot-Noirault E, Chezal JM, Weber V.
    Bioorg Chem; 2020 May 26; 98():103747. PubMed ID: 32208207
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  • 39. Pathways of reductive fragmentation of heterocyclic nitroarylmethyl quaternary ammonium prodrugs of mechlorethamine.
    Kriste AG, Tercel M, Anderson RF, Ferry DM, Wilson WR.
    Radiat Res; 2002 Dec 26; 158(6):753-62. PubMed ID: 12452778
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  • 40. 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine: an anticancer agent targeting hypoxic cells.
    Seow HA, Penketh PG, Shyam K, Rockwell S, Sartorelli AC.
    Proc Natl Acad Sci U S A; 2005 Jun 28; 102(26):9282-7. PubMed ID: 15964988
    [Abstract] [Full Text] [Related]

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