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Journal Abstract Search

201 related items for PubMed ID: 8685907

  • 1. CYP2E1-dependent bioactivation of 1,1-dichloroethylene in murine lung: formation of reactive intermediates and glutathione conjugates.
    Dowsley TF, Ulreich JB, Bolton JL, Park SS, Forkert PG.
    Toxicol Appl Pharmacol; 1996 Jul; 139(1):42-8. PubMed ID: 8685907
    [Abstract] [Full Text] [Related]

  • 2. Cytochrome P-450-dependent bioactivation of 1,1-dichloroethylene to a reactive epoxide in human lung and liver microsomes.
    Dowsley TF, Reid K, Petsikas D, Ulreich JB, Fisher RL, Forkert PG.
    J Pharmacol Exp Ther; 1999 May; 289(2):641-8. PubMed ID: 10215634
    [Abstract] [Full Text] [Related]

  • 3. In vivo formation and localization of 1,1-dichloroethylene epoxide in murine liver: identification of its glutathione conjugate 2-S-glutathionyl acetate.
    Forkert PG.
    J Pharmacol Exp Ther; 1999 Sep; 290(3):1299-306. PubMed ID: 10454507
    [Abstract] [Full Text] [Related]

  • 4. Differential formation of 1,1-dichloroethylene-metabolites in the lungs of adult and weanling male and female mice: correlation with severities of bronchiolar cytotoxicity.
    Forkert PG, Dowsley TF, Lee RP, Hong JY, Ulreich JB.
    J Pharmacol Exp Ther; 1996 Dec; 279(3):1484-90. PubMed ID: 8968374
    [Abstract] [Full Text] [Related]

  • 5. Pulmonary bioactivation of 1,1-dichloroethylene is associated with CYP2E1 levels in A/J, CD-1, and C57BL/6 mice.
    Forkert PG, Boyd SM, Ulreich JB.
    J Pharmacol Exp Ther; 2001 Jun; 297(3):1193-200. PubMed ID: 11356946
    [Abstract] [Full Text] [Related]

  • 6. Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes.
    Simmonds AC, Reilly CA, Baldwin RM, Ghanayem BI, Lanza DL, Yost GS, Collins KS, Forkert PG.
    Drug Metab Dispos; 2004 Sep; 32(9):1032-9. PubMed ID: 15319346
    [Abstract] [Full Text] [Related]

  • 7. Protection from 1,1-dichloroethylene-induced Clara cell injury by diallyl sulfone, a derivative of garlic.
    Forkert PG, Lee RP, Dowsley TF, Hong JY, Ulreich JB.
    J Pharmacol Exp Ther; 1996 Jun; 277(3):1665-71. PubMed ID: 8667236
    [Abstract] [Full Text] [Related]

  • 8. Pulmonary CYP2E1 bioactivates 1,1-dichloroethylene in male and female mice.
    Lee RP, Forkert PG.
    J Pharmacol Exp Ther; 1995 Apr; 273(1):561-7. PubMed ID: 7714813
    [Abstract] [Full Text] [Related]

  • 9. Diminished CYP2E1 expression and formation of 2-S-glutathionyl acetate, a glutathione conjugate derived from 1,1-dichloroethylene epoxide, in murine lung tumors.
    Forkert PG, Malkinson AM, Rice P, Moussa M.
    Drug Metab Dispos; 1999 Jan; 27(1):68-73. PubMed ID: 9884311
    [Abstract] [Full Text] [Related]

  • 10. Conjugation of glutathione with the reactive metabolites of 1, 1-dichloroethylene in murine lung and liver.
    Forkert PG.
    Microsc Res Tech; 1997 Feb 15; 36(4):234-42. PubMed ID: 9140924
    [Abstract] [Full Text] [Related]

  • 11. Reaction of glutathione with the electrophilic metabolites of 1,1-dichloroethylene.
    Dowsley TF, Forkert PG, Benesch LA, Bolton JL.
    Chem Biol Interact; 1995 Apr 14; 95(3):227-44. PubMed ID: 7728894
    [Abstract] [Full Text] [Related]

  • 12. Effect of hyperthyroidism on the in vitro metabolism and covalent binding of 1,1-dichloroethylene in rat liver microsomes.
    Gunasena GH, Kanz MF.
    J Toxicol Environ Health; 1997 Oct 10; 52(2):169-88. PubMed ID: 9310148
    [Abstract] [Full Text] [Related]

  • 13. In vitro biotransformation of 1,1-dichloroethylene by hepatic cytochrome P-450 2E1 in mice.
    Lee RP, Forkert PG.
    J Pharmacol Exp Ther; 1994 Jul 10; 270(1):371-6. PubMed ID: 8035334
    [Abstract] [Full Text] [Related]

  • 14. Differential metabolism of 1,1-dichloroethylene in livers of A/J, CD-1, and C57BL/6 mice.
    Forkert PG, Boyd SM.
    Drug Metab Dispos; 2001 Nov 10; 29(11):1396-402. PubMed ID: 11602514
    [Abstract] [Full Text] [Related]

  • 15. 1,1-Dichloroethylene-induced Clara cell damage is associated with in situ formation of the reactive epoxide. Immunohistochemical detection of its glutathione conjugate.
    Forkert PG.
    Am J Respir Cell Mol Biol; 1999 Jun 10; 20(6):1310-8. PubMed ID: 10340951
    [Abstract] [Full Text] [Related]

  • 16. Hepatic and pulmonary microsomal metabolism of naphthalene to glutathione adducts: factors affecting the relative rates of conjugate formation.
    Buckpitt AR, Bahnson LS, Franklin RB.
    J Pharmacol Exp Ther; 1984 Nov 10; 231(2):291-300. PubMed ID: 6491983
    [Abstract] [Full Text] [Related]

  • 17. Renal tumorigenicity of 1,1-dichloroethene in mice: the role of male-specific expression of cytochrome P450 2E1 in the renal bioactivation of 1,1-dichloroethene.
    Speerschneider P, Dekant W.
    Toxicol Appl Pharmacol; 1995 Jan 10; 130(1):48-56. PubMed ID: 7839370
    [Abstract] [Full Text] [Related]

  • 18. Formation of glutathione conjugates by reactive metabolites of vinylidene chloride in microsomes and isolated hepatocytes.
    Liebler DC, Meredith MJ, Guengerich FP.
    Cancer Res; 1985 Jan 10; 45(1):186-93. PubMed ID: 3965130
    [Abstract] [Full Text] [Related]

  • 19. In vitro metabolism and covalent binding of ethylbenzene to microsomal protein as a possible mechanism of ethylbenzene-induced mouse lung tumorigenesis.
    Saghir SA, Zhang F, Rick DL, Kan L, Bus JS, Bartels MJ.
    Regul Toxicol Pharmacol; 2010 Jan 10; 57(2-3):129-35. PubMed ID: 20096743
    [Abstract] [Full Text] [Related]

  • 20. Metabolism and bioactivation of 3-methylindole by human liver microsomes.
    Yan Z, Easterwood LM, Maher N, Torres R, Huebert N, Yost GS.
    Chem Res Toxicol; 2007 Jan 10; 20(1):140-8. PubMed ID: 17226936
    [Abstract] [Full Text] [Related]

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