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142 related items for PubMed ID: 8687482

  • 1. Bioactivation of mitomycin antibiotics by aerobic and hypoxic Chinese hamster ovary cells overexpressing DT-diaphorase.
    Belcourt MF, Hodnick WF, Rockwell S, Sartorelli AC.
    Biochem Pharmacol; 1996 Jun 28; 51(12):1669-78. PubMed ID: 8687482
    [Abstract] [Full Text] [Related]

  • 2. Exploring the mechanistic aspects of mitomycin antibiotic bioactivation in Chinese hamster ovary cells overexpressing NADPH:cytochrome C (P-450) reductase and DT-diaphorase.
    Belcourt MF, Hodnick WF, Rockwell S, Sartorelli AC.
    Adv Enzyme Regul; 1998 Jun 28; 38():111-33. PubMed ID: 9762350
    [Abstract] [Full Text] [Related]

  • 3. Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductase.
    Belcourt MF, Hodnick WF, Rockwell S, Sartorelli AC.
    Proc Natl Acad Sci U S A; 1996 Jan 09; 93(1):456-60. PubMed ID: 8552660
    [Abstract] [Full Text] [Related]

  • 4. Role of NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase) in activation of mitomycin C under acidic conditions.
    Begleiter A, Leith MK.
    Mol Pharmacol; 1993 Jul 09; 44(1):210-5. PubMed ID: 8341273
    [Abstract] [Full Text] [Related]

  • 5. Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C1.
    Keyes SR, Fracasso PM, Heimbrook DC, Rockwell S, Sligar SG, Sartorelli AC.
    Cancer Res; 1984 Dec 09; 44(12 Pt 1):5638-43. PubMed ID: 6437671
    [Abstract] [Full Text] [Related]

  • 6. Chinese hamster ovary cell lines resistant to mitomycin C under aerobic but not hypoxic conditions are deficient in DT-diaphorase.
    Dulhanty AM, Whitmore GF.
    Cancer Res; 1991 Apr 01; 51(7):1860-5. PubMed ID: 1900739
    [Abstract] [Full Text] [Related]

  • 7. Reversal of mitomycin C resistance by overexpression of bioreductive enzymes in Chinese hamster ovary cells.
    Baumann RP, Hodnick WF, Seow HA, Belcourt MF, Rockwell S, Sherman DH, Sartorelli AC.
    Cancer Res; 2001 Nov 01; 61(21):7770-6. PubMed ID: 11691791
    [Abstract] [Full Text] [Related]

  • 8. Modification of the metabolism and cytotoxicity of bioreductive alkylating agents by dicoumarol in aerobic and hypoxic murine tumor cells.
    Keyes SR, Rockwell S, Sartorelli AC.
    Cancer Res; 1989 Jun 15; 49(12):3310-3. PubMed ID: 2470504
    [Abstract] [Full Text] [Related]

  • 9. Chemotherapeutic attack of hypoxic tumor cells by the bioreductive alkylating agent mitomycin C.
    Keyes SR, Heimbrook DC, Fracasso PM, Rockwell S, Sligar SG, Sartorelli AC.
    Adv Enzyme Regul; 1985 Jun 15; 23():291-307. PubMed ID: 3934922
    [Abstract] [Full Text] [Related]

  • 10. Cytotoxicity and DNA lesions produced by mitomycin C and porfiromycin in hypoxic and aerobic EMT6 and Chinese hamster ovary cells.
    Fracasso PM, Sartorelli AC.
    Cancer Res; 1986 Aug 15; 46(8):3939-44. PubMed ID: 3089583
    [Abstract] [Full Text] [Related]

  • 11. The intracellular location of NADH:cytochrome b5 reductase modulates the cytotoxicity of the mitomycins to Chinese hamster ovary cells.
    Belcourt MF, Hodnick WF, Rockwell S, Sartorelli AC.
    J Biol Chem; 1998 Apr 10; 273(15):8875-81. PubMed ID: 9535868
    [Abstract] [Full Text] [Related]

  • 12. Role of NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase) in activation of mitomycin C under hypoxia.
    Begleiter A, Robotham E, Leith MK.
    Mol Pharmacol; 1992 Apr 10; 41(4):677-82. PubMed ID: 1373799
    [Abstract] [Full Text] [Related]

  • 13. Unusually marked hypoxic sensitization to indoloquinone EO9 and mitomycin C in a human colon-tumour cell line that lacks DT-diaphorase activity.
    Plumb JA, Workman P.
    Int J Cancer; 1994 Jan 02; 56(1):134-9. PubMed ID: 8262670
    [Abstract] [Full Text] [Related]

  • 14. Studies on the mechanism of resistance to mitomycin C and porfiromycin in a human cell strain derived from a cancer-prone individual.
    Marshall RS, Paterson MC, Rauth AM.
    Biochem Pharmacol; 1991 May 01; 41(9):1351-60. PubMed ID: 1902110
    [Abstract] [Full Text] [Related]

  • 15. Cytotoxicity of BMS-181174. Effects of hypoxia, dicoumarol, and repair deficits.
    Rockwell S, Kemple B, Kelley M.
    Biochem Pharmacol; 1995 Oct 12; 50(8):1239-43. PubMed ID: 7488240
    [Abstract] [Full Text] [Related]

  • 16. Characterization of a set of Chinese hamster ovary variant cell lines demonstrating differing sensitivity to mitomycin C.
    Kuehl BL, Buchwald M, Rauth AM.
    Oncol Res; 1993 Oct 12; 5(6-7):213-21. PubMed ID: 8123941
    [Abstract] [Full Text] [Related]

  • 17. Nuclear overexpression of NAD(P)H:quinone oxidoreductase 1 in Chinese hamster ovary cells increases the cytotoxicity of mitomycin C under aerobic and hypoxic conditions.
    Seow HA, Penketh PG, Belcourt MF, Tomasz M, Rockwell S, Sartorelli AC.
    J Biol Chem; 2004 Jul 23; 279(30):31606-12. PubMed ID: 15155746
    [Abstract] [Full Text] [Related]

  • 18. Nuclear overexpression of NADH:cytochrome b5 reductase activity increases the cytotoxicity of mitomycin C (MC) and the total number of MC-DNA adducts in Chinese hamster ovary cells.
    Holtz KM, Rockwell S, Tomasz M, Sartorelli AC.
    J Biol Chem; 2003 Feb 14; 278(7):5029-34. PubMed ID: 12424239
    [Abstract] [Full Text] [Related]

  • 19. pH-dependent inactivation of DT-diaphorase by mitomycin C and porfiromycin.
    Siegel D, Beall H, Kasai M, Arai H, Gibson NW, Ross D.
    Mol Pharmacol; 1993 Dec 14; 44(6):1128-34. PubMed ID: 8264549
    [Abstract] [Full Text] [Related]

  • 20. Relative importance of DT-diaphorase and hypoxia in the bioactivation of EO9 by human lung tumor cell lines.
    Plumb JA, Gerritsen M, Milroy R, Thomson P, Workman P.
    Int J Radiat Oncol Biol Phys; 1994 May 15; 29(2):295-9. PubMed ID: 8195022
    [Abstract] [Full Text] [Related]


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