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Journal Abstract Search

287 related items for PubMed ID: 8691448

  • 1. Hypoxia-selective antitumor agents. 13. Effects of acridine substitution on the hypoxia-selective cytotoxicity and metabolic reduction of the bis-bioreductive agent nitracrine N-oxide.
    Lee HH, Wilson WR, Ferry DM, van Zijl P, Pullen SM, Denny WA.
    J Med Chem; 1996 Jun 21; 39(13):2508-17. PubMed ID: 8691448
    [Abstract] [Full Text] [Related]

  • 2. Nitracrine N-oxides: effects of variations in the nature of the side chain N-oxide on hypoxia-selective cytotoxicity.
    Lee HH, Wilson WR, Denny WA.
    Anticancer Drug Des; 1999 Dec 21; 14(6):487-97. PubMed ID: 10834270
    [Abstract] [Full Text] [Related]

  • 3. Hypoxia-selective antitumor agents. 14. Synthesis and hypoxic cell cytotoxicity of regioisomers of the hypoxia-selective cytotoxin 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide.
    Palmer BD, Wilson WR, Anderson RF, Boyd M, Denny WA.
    J Med Chem; 1996 Jun 21; 39(13):2518-28. PubMed ID: 8691449
    [Abstract] [Full Text] [Related]

  • 4. Structure-activity relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine.
    Hay MP, Gamage SA, Kovacs MS, Pruijn FB, Anderson RF, Patterson AV, Wilson WR, Brown JM, Denny WA.
    J Med Chem; 2003 Jan 02; 46(1):169-82. PubMed ID: 12502371
    [Abstract] [Full Text] [Related]

  • 5. 5-Nitro-4-(N,N-dimethylaminopropylamino)quinoline (5-nitraquine), a new DNA-affinic hypoxic cell radiosensitizer and bioreductive agent: comparison with nitracrine.
    Wilson WR, Siim BG, Denny WA, van Zijl PL, Taylor ML, Chambers DM, Roberts PB.
    Radiat Res; 1992 Sep 02; 131(3):257-65. PubMed ID: 1438685
    [Abstract] [Full Text] [Related]

  • 6. Hypoxia-selective antitumor agents. 15. Modification of rate of nitroreduction and extent of lysosomal uptake by polysubstitution of 4-(alkylamino)-5-nitroquinoline bioreductive drugs.
    Siim BG, Atwell GJ, Anderson RF, Wardman P, Pullen SM, Wilson WR, Denny WA.
    J Med Chem; 1997 Apr 25; 40(9):1381-90. PubMed ID: 9135035
    [Abstract] [Full Text] [Related]

  • 7. Structure-activity relationships for substituted bis(acridine-4-carboxamides): a new class of anticancer agents.
    Gamage SA, Spicer JA, Atwell GJ, Finlay GJ, Baguley BC, Denny WA.
    J Med Chem; 1999 Jul 01; 42(13):2383-93. PubMed ID: 10395479
    [Abstract] [Full Text] [Related]

  • 8. Hypoxia-selective antitumor agents. 1. Relationships between structure, redox properties and hypoxia-selective cytotoxicity for 4-substituted derivatives of nitracrine.
    Wilson WR, Anderson RF, Denny WA.
    J Med Chem; 1989 Jan 01; 32(1):23-30. PubMed ID: 2909736
    [Abstract] [Full Text] [Related]

  • 9. Bis-bioreductive agents as hypoxia-selective cytotoxins: nitracrine N-oxide.
    Wilson WR, Van Zijl P, Denny WA.
    Int J Radiat Oncol Biol Phys; 1992 Jan 01; 22(4):693-6. PubMed ID: 1544839
    [Abstract] [Full Text] [Related]

  • 10. Hypoxia-selective antitumor agents. 2. Electronic effects of 4-substituents on the mechanisms of cytotoxicity and metabolic stability of nitracrine derivatives.
    Wilson WR, Thompson LH, Anderson RF, Denny WA.
    J Med Chem; 1989 Jan 01; 32(1):31-8. PubMed ID: 2909741
    [Abstract] [Full Text] [Related]

  • 11. Structure-activity relationships for acridine-substituted analogues of the mixed topoisomerase I/II inhibitor N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.
    Spicer JA, Gamage SA, Atwell GJ, Finlay GJ, Baguley BC, Denny WA.
    J Med Chem; 1997 Jun 06; 40(12):1919-29. PubMed ID: 9191970
    [Abstract] [Full Text] [Related]

  • 12. Hypoxia-selective antitumor agents. 12. Nitrobenzyl quaternary salts as bioreductive prodrugs of the alkylating agent mechlorethamine.
    Tercel M, Wilson WR, Anderson RF, Denny WA.
    J Med Chem; 1996 Mar 01; 39(5):1084-94. PubMed ID: 8676343
    [Abstract] [Full Text] [Related]

  • 13. Nitro analogues of chlorambucil as potential hypoxia-selective anti-tumour drugs.
    Palmer BD, Wilson WR, Denny WA.
    Anticancer Drug Des; 1990 Nov 01; 5(4):337-49. PubMed ID: 2291774
    [Abstract] [Full Text] [Related]

  • 14. Tertiary amine N-oxides as bioreductive drugs: DACA N-oxide, nitracrine N-oxide and AQ4N.
    Wilson WR, Denny WA, Pullen SM, Thompson KM, Li AE, Patterson LH, Lee HH.
    Br J Cancer Suppl; 1996 Jul 01; 27():S43-7. PubMed ID: 8763844
    [Abstract] [Full Text] [Related]

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  • 16. N-[2-(2-methyl-5-nitroimidazolyl)ethyl]-4-(2-nitroimidazolyl)butanamide (NSC 639862), a bisnitroimidazole with enhanced selectivity as a bioreductive drug.
    Moselen JW, Hay MP, Denny WA, Wilson WR.
    Cancer Res; 1995 Feb 01; 55(3):574-80. PubMed ID: 7834627
    [Abstract] [Full Text] [Related]

  • 17. 5,7-Disubstituted analogues of the mixed topoisomerase I/II poison N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA): DNA binding and patterns of cytotoxicity.
    Spicer JA, Finlay GJ, Baguley BC, Velea L, Graves DE, Denny WA.
    Anticancer Drug Des; 1999 Feb 01; 14(1):37-45. PubMed ID: 10363026
    [Abstract] [Full Text] [Related]

  • 18. Hypoxia-selective antitumor agents. 4. Relationships between structure, physicochemical properties, and hypoxia-selective cytotoxicity for nitracrine analogues with varying side chains: the "iminoacridan hypothesis".
    Denny WA, Atwell GJ, Anderson RF, Wilson WR.
    J Med Chem; 1990 May 01; 33(5):1288-95. PubMed ID: 2329552
    [Abstract] [Full Text] [Related]

  • 19.
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  • 20. NLNQ-1, a 2-[3-(2-nitro-1-imidazolyl) propylamino]-3-chloro-1,4-naphthoquinone, as a hypoxia-selective cytotoxin and radiosensitizer.
    Papadopoulou MV, Bloomer WD.
    In Vivo; 2008 May 01; 22(3):285-8. PubMed ID: 18610737
    [Abstract] [Full Text] [Related]

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