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Journal Abstract Search

114 related items for PubMed ID: 8692986

  • 1. Mechanism of anti-HIV action of masked alaninyl d4T-MP derivatives.
    Balzarini J, Karlsson A, Aquaro S, Perno CF, Cahard D, Naesens L, De Clercq E, McGuigan C.
    Proc Natl Acad Sci U S A; 1996 Jul 09; 93(14):7295-9. PubMed ID: 8692986
    [Abstract] [Full Text] [Related]

  • 2. Antiretrovirus specificity and intracellular metabolism of 2',3' -didehydro-2',3'-dideoxythymidine (stavudine) and its 5'-monophosphate triester prodrug So324.
    Balzarini J, Egberink H, Hartmann K, Cahard D, Vahlenkamp T, Thormar H, De Clercq E, McGuigan C.
    Mol Pharmacol; 1996 Nov 09; 50(5):1207-13. PubMed ID: 8913352
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  • 3. Metabolism and anti-HIV activity of phosphoramidate derivatives of D4T-MP with variations in the amino acid moiety.
    Naesens L, Cahard D, Salgado A, Bidois L, De Clercq E, McGuigan C, Balzarini J.
    Adv Exp Med Biol; 1998 Nov 09; 431():753-7. PubMed ID: 9598164
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  • 4. cycloSal-2',3'-dideoxy-2',3'-didehydrothymidine monophosphate (cycloSal-d4TMP): synthesis and antiviral evaluation of a new d4TMP delivery system.
    Meier C, Lorey M, De Clercq E, Balzarini J.
    J Med Chem; 1998 Apr 23; 41(9):1417-27. PubMed ID: 9554875
    [Abstract] [Full Text] [Related]

  • 5. Synthesis and evaluation of double-prodrugs against HIV. Conjugation of D4T with 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, emivirine)-type reverse transcriptase inhibitors via the SATE prodrug approach.
    Petersen L, Jørgensen PT, Nielsen C, Hansen TH, Nielsen J, Pedersen EB.
    J Med Chem; 2005 Feb 24; 48(4):1211-20. PubMed ID: 15715487
    [Abstract] [Full Text] [Related]

  • 6. Synthesis and anti-HIV evaluation of D4T and D4T 5'-monophosphate prodrugs.
    Sergheraert C, Pierlot C, Tartar A, Henin Y, Lemaitre M.
    J Med Chem; 1993 Apr 02; 36(7):826-30. PubMed ID: 8385224
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  • 7. Bis-cycloSal-d4T-monophosphates: drugs that deliver two molecules of bioactive nucleotides.
    Ducho C, Görbig U, Jessel S, Gisch N, Balzarini J, Meier C.
    J Med Chem; 2007 Mar 22; 50(6):1335-46. PubMed ID: 17328534
    [Abstract] [Full Text] [Related]

  • 8. Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite.
    McGuigan C, Cahard D, Sheeka HM, De Clercq E, Balzarini J.
    J Med Chem; 1996 Apr 12; 39(8):1748-53. PubMed ID: 8648614
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  • 10. Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine.
    Saboulard D, Naesens L, Cahard D, Salgado A, Pathirana R, Velazquez S, McGuigan C, De Clercq E, Balzarini J.
    Mol Pharmacol; 1999 Oct 12; 56(4):693-704. PubMed ID: 10496951
    [Abstract] [Full Text] [Related]

  • 11. The DiPPro approach: synthesis, hydrolysis, and antiviral activity of lipophilic d4T diphosphate prodrugs.
    Schulz T, Balzarini J, Meier C.
    ChemMedChem; 2014 Apr 12; 9(4):762-75. PubMed ID: 24616176
    [Abstract] [Full Text] [Related]

  • 12. The presence of substituents on the aryl moiety of the aryl phosphoramidate derivative of d4T enhances anti-HIV efficacy in cell culture: A structure-activity relationship.
    Siddiqui AQ, Ballatore C, McGuigan C, De Clercq E, Balzarini J.
    J Med Chem; 1999 Feb 11; 42(3):393-9. PubMed ID: 9986709
    [Abstract] [Full Text] [Related]

  • 13. Synthesis, and in vitro enzymatic and antiviral evaluation of d4T polyphosphate derivatives as chain terminators.
    Yang S, Pannecouque C, Herdewijn P.
    Chem Biodivers; 2012 Oct 11; 9(10):2186-94. PubMed ID: 23081918
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  • 15. Enhancing the aqueous solubility of d4T-based phosphoramidate prodrugs.
    Siddiqui A, McGuigan C, Ballatore C, Srinivasan S, De Clercq E, Balzarini J.
    Bioorg Med Chem Lett; 2000 Feb 21; 10(4):381-4. PubMed ID: 10714505
    [Abstract] [Full Text] [Related]

  • 16. D4T-5'-[p-bromophenyl methoxyalaninyl phosphate] as a potent and non-toxic anti-human immunodeficiency virus agent.
    Vig R, Venkatachalam TK, Uckun FM.
    Antivir Chem Chemother; 1998 Sep 21; 9(5):445-8. PubMed ID: 9875398
    [Abstract] [Full Text] [Related]

  • 17. Synthesis, nanosizing and in vitro drug release of a novel anti-HIV polymeric prodrug: chitosan-O-isopropyl-5'-O-d4T monophosphate conjugate.
    Yang L, Chen L, Zeng R, Li C, Qiao R, Hu L, Li Z.
    Bioorg Med Chem; 2010 Jan 01; 18(1):117-23. PubMed ID: 19959368
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  • 20. Imidazo[1,5-b]pyridazine-d4T conjugates: synthesis and anti-human immunodeficiency virus evaluation.
    Renoud-Grappin M, Fossey C, Fontaine G, Ladurée D, Aubertin AM, Kirn A.
    Antivir Chem Chemother; 1998 May 01; 9(3):205-23. PubMed ID: 9875400
    [Abstract] [Full Text] [Related]

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