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304 related items for PubMed ID: 8698629

  • 21. Determinants of activity of the antifolate thymidylate synthase inhibitors Tomudex (ZD1694) and GW1843U89 against mono- and multilayered colon cancer cell lines under folate-restricted conditions.
    Peters GJ, Smitskamp-Wilms E, Smid K, Pinedo HM, Jansen G.
    Cancer Res; 1999 Nov 01; 59(21):5529-35. PubMed ID: 10554030
    [Abstract] [Full Text] [Related]

  • 22. Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines.
    Liani E, Rothem L, Bunni MA, Smith CA, Jansen G, Assaraf YG.
    Int J Cancer; 2003 Feb 20; 103(5):587-99. PubMed ID: 12494465
    [Abstract] [Full Text] [Related]

  • 23. LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes.
    Shih C, Chen VJ, Gossett LS, Gates SB, MacKellar WC, Habeck LL, Shackelford KA, Mendelsohn LG, Soose DJ, Patel VF, Andis SL, Bewley JR, Rayl EA, Moroson BA, Beardsley GP, Kohler W, Ratnam M, Schultz RM.
    Cancer Res; 1997 Mar 15; 57(6):1116-23. PubMed ID: 9067281
    [Abstract] [Full Text] [Related]

  • 24. Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
    Diddens H, Niethammer D, Jackson RC.
    Cancer Res; 1983 Nov 15; 43(11):5286-92. PubMed ID: 6225514
    [Abstract] [Full Text] [Related]

  • 25. Functional aspects of membrane folate receptors in human breast cancer cells with transport-related resistance to methotrexate.
    Pinard MF, Jolivet J, Ratnam M, Kathmann I, Molthoff C, Westerhof R, Schornagel JH, Jansen G.
    Cancer Chemother Pharmacol; 1996 Nov 15; 38(3):281-8. PubMed ID: 8646804
    [Abstract] [Full Text] [Related]

  • 26. Confocal microscopy visualization of antifolate uptake by the reduced folate carrier in human leukaemic cells.
    Jolivet J, Faure MP, Wong SC, Taub JW, Matherly LH.
    Br J Cancer; 1997 Nov 15; 76(6):734-8. PubMed ID: 9310238
    [Abstract] [Full Text] [Related]

  • 27. Selective preservation of pemetrexed pharmacological activity in HeLa cells lacking the reduced folate carrier: association with the presence of a secondary transport pathway.
    Zhao R, Hanscom M, Chattopadhyay S, Goldman ID.
    Cancer Res; 2004 May 01; 64(9):3313-9. PubMed ID: 15126375
    [Abstract] [Full Text] [Related]

  • 28. Amplification of the thymidylate synthase gene in an N10-propargyl-5,8-dideazafolic-acid-resistant human leukemia, MOLT-3 cell line developed in pteroylglutamic acid, but not in leucovorin.
    Miyachi H, Takemura Y, Kobayashi H, Ando Y.
    J Cancer Res Clin Oncol; 1996 May 01; 122(11):659-64. PubMed ID: 8898975
    [Abstract] [Full Text] [Related]

  • 29. Multidrug resistance in a human leukemic cell line selected for resistance to trimetrexate.
    Arkin H, Ohnuma T, Kamen BA, Holland JF, Vallabhajosula S.
    Cancer Res; 1989 Dec 01; 49(23):6556-61. PubMed ID: 2573416
    [Abstract] [Full Text] [Related]

  • 30. Impact of polyglutamation on sensitivity to raltitrexed and methotrexate in relation to drug-induced inhibition of de novo thymidylate and purine biosynthesis in CCRF-CEM cell lines.
    Barnes MJ, Estlin EJ, Taylor GA, Aherne GW, Hardcastle A, McGuire JJ, Calvete JA, Lunec J, Pearson AD, Newell DR.
    Clin Cancer Res; 1999 Sep 01; 5(9):2548-58. PubMed ID: 10499632
    [Abstract] [Full Text] [Related]

  • 31. Molecular characterization of human acute leukemia cell line resistant to ZD9331, a non-polyglutamatable thymidylate synthase inhibitor.
    Kobayashi H, Takemura Y, Miyachi H.
    Cancer Chemother Pharmacol; 1998 Sep 01; 42(2):105-10. PubMed ID: 9654109
    [Abstract] [Full Text] [Related]

  • 32. Relationships between resistance to cisplatin and antifolates in sensitive and resistant tumour cell lines.
    Kelland LR, Kimbell R, Hardcastle A, Aherne GW, Jackman AL.
    Eur J Cancer; 1995 Jun 01; 31A(6):981-6. PubMed ID: 7646933
    [Abstract] [Full Text] [Related]

  • 33.
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  • 34. Biological activity of the multitargeted antifolate, MTA (LY231514), in human cell lines with different resistance mechanisms to antifolate drugs.
    Schultz RM, Chen VJ, Bewley JR, Roberts EF, Shih C, Dempsey JA.
    Semin Oncol; 1999 Apr 01; 26(2 Suppl 6):68-73. PubMed ID: 10598558
    [Abstract] [Full Text] [Related]

  • 35. Ex vivo activity of methotrexate versus novel antifolate inhibitors of dihydrofolate reductase and thymidylate synthase against childhood leukemia cells.
    Mauritz R, Bekkenk MW, Rots MG, Pieters R, Mini E, van Zantwijk CH, Veerman AJ, Peters GJ, Jansen G.
    Clin Cancer Res; 1998 Oct 01; 4(10):2399-410. PubMed ID: 9796971
    [Abstract] [Full Text] [Related]

  • 36. Dihydrofolate reductase binding and cellular uptake of nonpolyglutamatable antifolates: correlates of cytotoxicity toward methotrexate-sensitive and -resistant human head and neck squamous carcinoma cells.
    Chen G, Wright JE, Rosowsky A.
    Mol Pharmacol; 1995 Oct 01; 48(4):758-65. PubMed ID: 7476904
    [Abstract] [Full Text] [Related]

  • 37. The mechanism of transport of the multitargeted antifolate (MTA) and its cross-resistance pattern in cells with markedly impaired transport of methotrexate.
    Zhao R, Babani S, Gao F, Liu L, Goldman ID.
    Clin Cancer Res; 2000 Sep 01; 6(9):3687-95. PubMed ID: 10999762
    [Abstract] [Full Text] [Related]

  • 38. Multiple membrane transport systems for the uptake of folate-based thymidylate synthase inhibitors.
    Jansen G, Schornagel JH, Westerhof GR, Rijksen G, Newell DR, Jackman AL.
    Cancer Res; 1990 Dec 01; 50(23):7544-8. PubMed ID: 2253202
    [Abstract] [Full Text] [Related]

  • 39. Folate-based thymidylate synthase inhibitors as anticancer drugs.
    Jackman AL, Calvert AH.
    Ann Oncol; 1995 Nov 01; 6(9):871-81. PubMed ID: 8624289
    [Abstract] [Full Text] [Related]

  • 40. Immunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition; effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukaemia cells.
    Aherne GW, Hardcastle A, Raynaud F, Jackman AL.
    Biochem Pharmacol; 1996 May 17; 51(10):1293-301. PubMed ID: 8787544
    [Abstract] [Full Text] [Related]

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