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Journal Abstract Search

133 related items for PubMed ID: 8742240

  • 1. Putative active site template model for cytochrome P4502C9 (tolbutamide hydroxylase).
    Jones BC, Hawksworth G, Horne VA, Newlands A, Morsman J, Tute MS, Smith DA.
    Drug Metab Dispos; 1996 Feb; 24(2):260-6. PubMed ID: 8742240
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  • 2. The substrate binding site of human liver cytochrome P450 2C9: an NMR study.
    Poli-Scaife S, Attias R, Dansette PM, Mansuy D.
    Biochemistry; 1997 Oct 21; 36(42):12672-82. PubMed ID: 9335524
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  • 3. Enzymatic determinants of the substrate specificity of CYP2C9: role of B'-C loop residues in providing the pi-stacking anchor site for warfarin binding.
    Haining RL, Jones JP, Henne KR, Fisher MB, Koop DR, Trager WF, Rettie AE.
    Biochemistry; 1999 Mar 16; 38(11):3285-92. PubMed ID: 10079071
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  • 4. Interaction of sulfaphenazole derivatives with human liver cytochromes P450 2C: molecular origin of the specific inhibitory effects of sulfaphenazole on CYP 2C9 and consequences for the substrate binding site topology of CYP 2C9.
    Mancy A, Dijols S, Poli S, Guengerich P, Mansuy D.
    Biochemistry; 1996 Dec 17; 35(50):16205-12. PubMed ID: 8973193
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  • 5. Three- and four-dimensional-quantitative structure activity relationship (3D/4D-QSAR) analyses of CYP2C9 inhibitors.
    Ekins S, Bravi G, Binkley S, Gillespie JS, Ring BJ, Wikel JH, Wrighton SA.
    Drug Metab Dispos; 2000 Aug 17; 28(8):994-1002. PubMed ID: 10901712
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  • 6. Structural forms of phenprocoumon and warfarin that are metabolized at the active site of CYP2C9.
    He M, Korzekwa KR, Jones JP, Rettie AE, Trager WF.
    Arch Biochem Biophys; 1999 Dec 01; 372(1):16-28. PubMed ID: 10562412
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  • 11. Dapsone activation of CYP2C9-mediated metabolism: evidence for activation of multiple substrates and a two-site model.
    Hutzler JM, Hauer MJ, Tracy TS.
    Drug Metab Dispos; 2001 Jul 01; 29(7):1029-34. PubMed ID: 11408370
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  • 13. Identification of residues 286 and 289 as critical for conferring substrate specificity of human CYP2C9 for diclofenac and ibuprofen.
    Klose TS, Ibeanu GC, Ghanayem BI, Pedersen LG, Li L, Hall SD, Goldstein JA.
    Arch Biochem Biophys; 1998 Sep 15; 357(2):240-8. PubMed ID: 9735164
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  • 14. Speculations on the substrate structure-activity relationship (SSAR) of cytochrome P450 enzymes.
    Smith DA, Jones BC.
    Biochem Pharmacol; 1992 Dec 01; 44(11):2089-98. PubMed ID: 1472073
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  • 15. Three-dimensional quantitative structure-activity relationship for inhibitors of cytochrome P4502C9.
    Jones JP, He M, Trager WF, Rettie AE.
    Drug Metab Dispos; 1996 Jan 01; 24(1):1-6. PubMed ID: 8825183
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  • 16. Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes.
    Thijssen HH, Flinois JP, Beaune PH.
    Drug Metab Dispos; 2000 Nov 01; 28(11):1284-90. PubMed ID: 11038154
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  • 17. Substrate probe for the mechanism of aromatic hydroxylation catalyzed by cytochrome P450.
    Darbyshire JF, Iyer KR, Grogan J, Korzekwa KR, Trager WF.
    Drug Metab Dispos; 1996 Sep 01; 24(9):1038-45. PubMed ID: 8886617
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  • 19. Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants.
    Melet A, Marques-Soares C, Schoch GA, Macherey AC, Jaouen M, Dansette PM, Sari MA, Johnson EF, Mansuy D.
    Biochemistry; 2004 Dec 14; 43(49):15379-92. PubMed ID: 15581350
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  • 20. CYP2C9 structure-metabolism relationships: substrates, inhibitors, and metabolites.
    Ahlström MM, Ridderström M, Zamora I.
    J Med Chem; 2007 Nov 01; 50(22):5382-91. PubMed ID: 17915853
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