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147 related items for PubMed ID: 8745399

  • 1. Crystallographic determination of the structures of human alpha-thrombin complexed with BMS-186282 and BMS-189090.
    Malley MF, Tabernero L, Chang CY, Ohringer SL, Roberts DG, Das J, Sack JS.
    Protein Sci; 1996 Feb; 5(2):221-8. PubMed ID: 8745399
    [Abstract] [Full Text] [Related]

  • 2. The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin.
    Vijayalakshmi J, Padmanabhan KP, Mann KG, Tulinsky A.
    Protein Sci; 1994 Dec; 3(12):2254-71. PubMed ID: 7756983
    [Abstract] [Full Text] [Related]

  • 3. Structure of a retro-binding peptide inhibitor complexed with human alpha-thrombin.
    Tabernero L, Chang CY, Ohringer SL, Lau WF, Iwanowicz EJ, Han WC, Wang TC, Seiler SM, Roberts DG, Sack JS.
    J Mol Biol; 1995 Feb 10; 246(1):14-20. PubMed ID: 7853394
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  • 4. Thrombin active site inhibitors: chemical synthesis, in vitro and in vivo pharmacological profile of a novel and selective agent BMS-189090 and analogues.
    Das J, Kimball SD, Reid JA, Wang TC, Lau WF, Roberts DG, Seiler SM, Schumacher WA, Ogletree ML.
    Bioorg Med Chem Lett; 2002 Jan 07; 12(1):41-4. PubMed ID: 11738569
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  • 9. In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
    Costanzo MJ, Almond HR, Hecker LR, Schott MR, Yabut SC, Zhang HC, Andrade-Gordon P, Corcoran TW, Giardino EC, Kauffman JA, Lewis JM, de Garavilla L, Haertlein BJ, Maryanoff BE.
    J Med Chem; 2005 Mar 24; 48(6):1984-2008. PubMed ID: 15771442
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  • 10. Profiling the structural determinants for the selectivity of representative factor-Xa and thrombin inhibitors using combined ligand-based and structure-based approaches.
    Bhunia SS, Roy KK, Saxena AK.
    J Chem Inf Model; 2011 Aug 22; 51(8):1966-85. PubMed ID: 21761917
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  • 11. The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships.
    Bode W, Turk D, Karshikov A.
    Protein Sci; 1992 Apr 22; 1(4):426-71. PubMed ID: 1304349
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  • 12. Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human alpha-thrombin.
    Féthière J, Tsuda Y, Coulombe R, Konishi Y, Cygler M.
    Protein Sci; 1996 Jun 22; 5(6):1174-83. PubMed ID: 8762149
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  • 13. Design of weakly basic thrombin inhibitors incorporating novel P1 binding functions: molecular and X-ray crystallographic studies.
    De Simone G, Menchise V, Omaggio S, Pedone C, Scozzafava A, Supuran CT.
    Biochemistry; 2003 Aug 05; 42(30):9013-21. PubMed ID: 12885234
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  • 14. Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes.
    Krishnan R, Zhang E, Hakansson K, Arni RK, Tulinsky A, Lim-Wilby MS, Levy OE, Semple JE, Brunck TK.
    Biochemistry; 1998 Sep 01; 37(35):12094-103. PubMed ID: 9724521
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  • 15. The structure of a designed peptidomimetic inhibitor complex of alpha-thrombin.
    Wu TP, Yee V, Tulinsky A, Chrusciel RA, Nakanishi H, Shen R, Priebe C, Kahn M.
    Protein Eng; 1993 Jul 01; 6(5):471-8. PubMed ID: 8415574
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  • 16. Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6.
    Zdanov A, Wu S, DiMaio J, Konishi Y, Li Y, Wu X, Edwards BF, Martin PD, Cygler M.
    Proteins; 1993 Nov 01; 17(3):252-65. PubMed ID: 8272424
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  • 17. Inhibition of thrombin by arginine-containing peptide chloromethyl ketones and bis chloromethyl ketone-albumin conjugates.
    Odake S, Kam CM, Powers JC.
    J Enzyme Inhib; 1995 Nov 01; 9(1):17-27. PubMed ID: 8568563
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  • 18. Human alpha-thrombin inhibition by the active site titrant N alpha-(N,N-dimethylcarbamoyl)-alpha-azalysine p-nitrophenyl ester: a comparative kinetic and X-ray crystallographic study.
    Nardini M, Pesce A, Rizzi M, Casale E, Ferraccioli R, Balliano G, Milla P, Ascenzi P, Bolognesi M.
    J Mol Biol; 1996 May 24; 258(5):851-9. PubMed ID: 8637015
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  • 19. Structures of thrombin retro-inhibited with SEL2711 and SEL2770 as they relate to factor Xa binding.
    Mochalkin I, Tulinsky A.
    Acta Crystallogr D Biol Crystallogr; 1999 Apr 24; 55(Pt 4):785-93. PubMed ID: 10089309
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  • 20. Rational design, synthesis, and X-ray structure of selective noncovalent thrombin inhibitors.
    Wagner J, Kallen J, Ehrhardt C, Evenou JP, Wagner D.
    J Med Chem; 1998 Sep 10; 41(19):3664-74. PubMed ID: 9733491
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