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Journal Abstract Search

173 related items for PubMed ID: 8759623

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  • 4. Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes.
    Krishnan R, Zhang E, Hakansson K, Arni RK, Tulinsky A, Lim-Wilby MS, Levy OE, Semple JE, Brunck TK.
    Biochemistry; 1998 Sep 01; 37(35):12094-103. PubMed ID: 9724521
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  • 7. Potent, small-molecule inhibitors of human mast cell tryptase. Antiasthmatic action of a dipeptide-based transition-state analogue containing a benzothiazole ketone.
    Costanzo MJ, Yabut SC, Almond HR, Andrade-Gordon P, Corcoran TW, De Garavilla L, Kauffman JA, Abraham WM, Recacha R, Chattopadhyay D, Maryanoff BE.
    J Med Chem; 2003 Aug 28; 46(18):3865-76. PubMed ID: 12930148
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  • 10. Amidinohydrazones as guanidine bioisosteres: application to a new class of potent, selective and orally bioavailable, non-amide-based small-molecule thrombin inhibitors.
    Soll RM, Lu T, Tomczuk B, Illig CR, Fedde C, Eisennagel S, Bone R, Murphy L, Spurlino J, Salemme FR.
    Bioorg Med Chem Lett; 2000 Jan 03; 10(1):1-4. PubMed ID: 10636229
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  • 11. Episelection: novel Ki approximately nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface.
    Katz BA, Finer-Moore J, Mortezaei R, Rich DH, Stroud RM.
    Biochemistry; 1995 Jul 04; 34(26):8264-80. PubMed ID: 7599119
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  • 12. Design of P1' and P3' residues of trivalent thrombin inhibitors and their crystal structures.
    Slon-Usakiewicz JJ, Sivaraman J, Li Y, Cygler M, Konishi Y.
    Biochemistry; 2000 Mar 07; 39(9):2384-91. PubMed ID: 10694407
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  • 13. From natural products to achiral drug prototypes: potent thrombin inhibitors based on P2/P3 dihydropyrid-2-one core motifs.
    Hanessian S, Therrien E, Zhang J, Otterlo Wv, Xue Y, Gustafsson D, Nilsson I, Fjellström O.
    Bioorg Med Chem Lett; 2009 Sep 15; 19(18):5429-32. PubMed ID: 19674897
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  • 16. Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa.
    Phillips GB, Buckman BO, Davey DD, Eagen KA, Guilford WJ, Hinchman J, Ho E, Koovakkat S, Liang A, Light DR, Mohan R, Ng HP, Post JM, Shaw KJ, Smith D, Subramanyam B, Sullivan ME, Trinh L, Vergona R, Walters J, White K, Whitlow M, Wu S, Xu W, Morrissey MM.
    J Med Chem; 1998 Sep 10; 41(19):3557-62. PubMed ID: 9733480
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  • 17. Discovery of benzothiazole guanidines as novel inhibitors of thrombin and trypsin IV.
    Karle M, Knecht W, Xue Y.
    Bioorg Med Chem Lett; 2012 Jul 15; 22(14):4839-43. PubMed ID: 22726924
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  • 18. Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human alpha-thrombin.
    Féthière J, Tsuda Y, Coulombe R, Konishi Y, Cygler M.
    Protein Sci; 1996 Jun 15; 5(6):1174-83. PubMed ID: 8762149
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  • 20. Design and synthesis of redox stable analogues of sunflower trypsin inhibitors (SFTI-1) on solid support, potent inhibitors of matriptase.
    Jiang S, Li P, Lee SL, Lin CY, Long YQ, Johnson MD, Dickson RB, Roller PP.
    Org Lett; 2007 Jan 04; 9(1):9-12. PubMed ID: 17192072
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