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Journal Abstract Search

149 related items for PubMed ID: 8763850

  • 1. Chemical properties which control selectivity and efficacy of aromatic N-oxide bioreductive drugs.
    Wardman P, Priyadarsini KI, Dennis MF, Everett SA, Naylor MA, Patel KB, Stratford IJ, Stratford MR, Tracy M.
    Br J Cancer Suppl; 1996 Jul; 27():S70-4. PubMed ID: 8763850
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  • 2. Oxidation of 2-deoxyribose by benzotriazinyl radicals of antitumor 3-amino-1,2,4-benzotriazine 1,4-dioxides.
    Shinde SS, Anderson RF, Hay MP, Gamage SA, Denny WA.
    J Am Chem Soc; 2004 Jun 30; 126(25):7865-74. PubMed ID: 15212534
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  • 3. Potentiation of the cytotoxicity of the anticancer agent tirapazamine by benzotriazine N-oxides: the role of redox equilibria.
    Anderson RF, Shinde SS, Hay MP, Denny WA.
    J Am Chem Soc; 2006 Jan 11; 128(1):245-9. PubMed ID: 16390153
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  • 4. Activation of 3-amino-1,2,4-benzotriazine 1,4-dioxide antitumor agents to oxidizing species following their one-electron reduction.
    Anderson RF, Shinde SS, Hay MP, Gamage SA, Denny WA.
    J Am Chem Soc; 2003 Jan 22; 125(3):748-56. PubMed ID: 12526674
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  • 5. Reaction of the hypoxia-selective antitumor agent tirapazamine with a C1'-radical in single-stranded and double-stranded DNA: the drug and its metabolites can serve as surrogates for molecular oxygen in radical-mediated DNA damage reactions.
    Hwang JT, Greenberg MM, Fuchs T, Gates KS.
    Biochemistry; 1999 Oct 26; 38(43):14248-55. PubMed ID: 10571998
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  • 7. The one-electron reduction potential of 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine): a hypoxia-selective bioreductive drug.
    Priyadarsini KI, Tracy M, Wardman P.
    Free Radic Res; 1996 Nov 26; 25(5):393-9. PubMed ID: 8902537
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  • 8. Pulse radiolysis of the DNA-binding bisbenzimidazole derivatives Hoechst 33258 and 33342 in aqueous solutions.
    Adhikary A, Bothe E, Jain V, Von Sonntag C.
    Int J Radiat Biol; 2000 Sep 26; 76(9):1157-66. PubMed ID: 10993627
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  • 12. Characterization of radicals formed following enzymatic reduction of 3-substituted analogues of the hypoxia-selective cytotoxin 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
    Shinde SS, Maroz A, Hay MP, Patterson AV, Denny WA, Anderson RF.
    J Am Chem Soc; 2010 Mar 03; 132(8):2591-9. PubMed ID: 20141134
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  • 13. A mass spectrometry study of tirapazamine and its metabolites. insights into the mechanism of metabolic transformations and the characterization of reaction intermediates.
    Zagorevskii D, Song M, Breneman C, Yuan Y, Fuchs T, Gates KS, Greenlief CM.
    J Am Soc Mass Spectrom; 2003 Aug 03; 14(8):881-92. PubMed ID: 12892912
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  • 14. Electron paramagnetic resonance spectrometry evidence for bioreduction of tirapazamine to oxidising free radicals under anaerobic conditions.
    Patterson LH, Taiwo FA.
    Biochem Pharmacol; 2000 Dec 15; 60(12):1933-5. PubMed ID: 11108810
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  • 15. Electrochemical properties as a function of pH for the benzotriazine di-N-oxides.
    Tocher JH, Virk NS, Edwards DI.
    Free Radic Res Commun; 1990 Dec 15; 10(4-5):295-302. PubMed ID: 2289695
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  • 16. Spin Trapping Hydroxyl and Aryl Radicals of One-Electron Reduced Anticancer Benzotriazine 1,4-Dioxides.
    Qi W, Yadav P, Hong CR, Stevenson RJ, Hay MP, Anderson RF.
    Molecules; 2022 Jan 26; 27(3):. PubMed ID: 35164077
    [Abstract] [Full Text] [Related]

  • 17. Toward hypoxia-selective DNA-alkylating agents built by grafting nitrogen mustards onto the bioreductively activated, hypoxia-selective DNA-oxidizing agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
    Johnson KM, Parsons ZD, Barnes CL, Gates KS.
    J Org Chem; 2014 Aug 15; 79(16):7520-31. PubMed ID: 25029663
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  • 18. Electron transfer reactions in RB90745, a bioreductive drug having both aromatic N-oxide and nitroarene moieties.
    Priyadarsini KI, Naylor MA, Stratford MR, Wardman P.
    Free Radic Res; 1996 Aug 15; 25(2):99-107. PubMed ID: 8885327
    [Abstract] [Full Text] [Related]

  • 19. Photochemical and photobiological studies of tirapazamine (SR 4233) and related quinoxaline 1,4-Di-N-oxide analogues.
    Inbaraj JJ, Motten AG, Chignell CF.
    Chem Res Toxicol; 2003 Feb 15; 16(2):164-70. PubMed ID: 12588187
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  • 20. Enhanced conversion of DNA radical damage to double strand breaks by 1,2,4-benzotriazine 1,4-dioxides linked to a DNA binder compared to tirapazamine.
    Anderson RF, Harris TA, Hay MP, Denny WA.
    Chem Res Toxicol; 2003 Nov 15; 16(11):1477-83. PubMed ID: 14615975
    [Abstract] [Full Text] [Related]

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