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153 related items for PubMed ID: 8781780

  • 1. P450-dependent and nonenzymatic human liver microsomal defluorination of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), a sevoflurane degradation product.
    Kharasch ED, Hankins DC.
    Drug Metab Dispos; 1996 Jun; 24(6):649-54. PubMed ID: 8781780
    [Abstract] [Full Text] [Related]

  • 2. Sulfoxidation of cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A).
    Altuntas TG, Park SB, Kharasch ED.
    Chem Res Toxicol; 2004 Mar; 17(3):435-45. PubMed ID: 15025515
    [Abstract] [Full Text] [Related]

  • 3. Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats.
    Sheffels P, Schroeder JL, Altuntas TG, Liggitt HD, Kharasch ED.
    Chem Res Toxicol; 2004 Sep; 17(9):1177-89. PubMed ID: 15377151
    [Abstract] [Full Text] [Related]

  • 4. Glutathione S-conjugation of the sevoflurane degradation product, fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human liver, kidney, and blood in vitro.
    Altuntas TG, Kharasch ED.
    Toxicol Appl Pharmacol; 2001 Dec 01; 177(2):85-93. PubMed ID: 11740907
    [Abstract] [Full Text] [Related]

  • 5. Dose-dependent metabolism of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), an anesthetic degradation product, to mercapturic acids and 3,3,3-trifluoro-2-(fluoromethoxy)propanoic acid in rats.
    Kharasch ED, Jubert C, Spracklin DK, Hoffman GM.
    Toxicol Appl Pharmacol; 1999 Oct 01; 160(1):49-59. PubMed ID: 10502502
    [Abstract] [Full Text] [Related]

  • 6. Evidence for metabolism of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), a sevoflurane degradation product, by cysteine conjugate beta-lyase.
    Spracklin DK, Kharasch ED.
    Chem Res Toxicol; 1996 Jun 01; 9(4):696-702. PubMed ID: 8831812
    [Abstract] [Full Text] [Related]

  • 7. Biotransformation of L-cysteine S-conjugates and N-acetyl-L-cysteine S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human kidney in vitro: interindividual variability in N-acetylation, N-deacetylation, and beta-lyase-catalyzed metabolism.
    Gul Altuntas T, Kharasch ED.
    Drug Metab Dispos; 2002 Feb 01; 30(2):148-54. PubMed ID: 11792683
    [Abstract] [Full Text] [Related]

  • 8. Cytotoxicity of S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl) vinyl ether (Compound A) in a human proximal tubular cell line.
    Altuntas TG, Zager RA, Kharasch ED.
    Toxicol Appl Pharmacol; 2003 Nov 15; 193(1):55-65. PubMed ID: 14613716
    [Abstract] [Full Text] [Related]

  • 9. Gene expression profiling of nephrotoxicity from the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether ("compound A") in rats.
    Kharasch ED, Schroeder JL, Bammler T, Beyer R, Srinouanprachanh S.
    Toxicol Sci; 2006 Apr 15; 90(2):419-31. PubMed ID: 16384817
    [Abstract] [Full Text] [Related]

  • 10. Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane.
    Kharasch ED, Thummel KE.
    Anesthesiology; 1993 Oct 15; 79(4):795-807. PubMed ID: 8214760
    [Abstract] [Full Text] [Related]

  • 11. Identification in rat bile of glutathione conjugates of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether, a nephrotoxic degradate of the anesthetic agent sevoflurane.
    Jin L, Davis MR, Kharasch ED, Doss GA, Baillie TA.
    Chem Res Toxicol; 1996 Mar 15; 9(2):555-61. PubMed ID: 8839062
    [Abstract] [Full Text] [Related]

  • 12. Human kidney methoxyflurane and sevoflurane metabolism. Intrarenal fluoride production as a possible mechanism of methoxyflurane nephrotoxicity.
    Kharasch ED, Hankins DC, Thummel KE.
    Anesthesiology; 1995 Mar 15; 82(3):689-99. PubMed ID: 7879937
    [Abstract] [Full Text] [Related]

  • 13. Characterization of the NADPH-dependent covalent binding of [14C]halothane to human liver microsomes: a role for cytochrome P4502E1 at low substrate concentrations.
    Madan A, Parkinson A.
    Drug Metab Dispos; 1996 Dec 15; 24(12):1307-13. PubMed ID: 8971135
    [Abstract] [Full Text] [Related]

  • 14. Renal toxicity with sevoflurane: a storm in a teacup?
    Gentz BA, Malan TP.
    Drugs; 2001 Dec 15; 61(15):2155-62. PubMed ID: 11772127
    [Abstract] [Full Text] [Related]

  • 15. Cytochrome P450 2E1 is the principal catalyst of human oxidative halothane metabolism in vitro.
    Spracklin DK, Hankins DC, Fisher JM, Thummel KE, Kharasch ED.
    J Pharmacol Exp Ther; 1997 Apr 15; 281(1):400-11. PubMed ID: 9103523
    [Abstract] [Full Text] [Related]

  • 16. Assessment of low-flow sevoflurane and isoflurane effects on renal function using sensitive markers of tubular toxicity.
    Kharasch ED, Frink EJ, Zager R, Bowdle TA, Artru A, Nogami WM.
    Anesthesiology; 1997 Jun 15; 86(6):1238-53. PubMed ID: 9197292
    [Abstract] [Full Text] [Related]

  • 17. Effect of phenytoin (DPH) treatment on methoxyflurane metabolism in rats.
    Caughey GH, Rice SA, Kosek JC, Mazze RI.
    J Pharmacol Exp Ther; 1979 Aug 15; 210(2):180-5. PubMed ID: 458627
    [Abstract] [Full Text] [Related]

  • 18. Oxidative defluorination of 1,1,1,2-tetrafluoroethane by rat liver microsomes.
    Olson MJ, Reidy CA, Johnson JT, Pederson TC.
    Drug Metab Dispos; 1990 Aug 15; 18(6):992-8. PubMed ID: 1981550
    [Abstract] [Full Text] [Related]

  • 19. Human liver microsomal enflurane defluorination catalyzed by cytochrome P-450 2E1.
    Thummel KE, Kharasch ED, Podoll T, Kunze K.
    Drug Metab Dispos; 1993 Aug 15; 21(2):350-7. PubMed ID: 8097708
    [Abstract] [Full Text] [Related]

  • 20. Metabolism by rat hepatic microsomes of fluorinated ether anesthetics following ethanol consumption.
    Rice SA, Dooley JR, Mazze RI.
    Anesthesiology; 1983 Mar 15; 58(3):237-41. PubMed ID: 6829959
    [Abstract] [Full Text] [Related]

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