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75 related items for PubMed ID: 8786538

  • 1. Mixed agonist/antagonist activity of an FK-506-related immunosuppressant: biological and biochemical characterization.
    Dumont FJ, Ok H, Lin S, Kastner CA, Cryan J, Martin MM, Wiederrecht G, Staruch MJ.
    J Pharmacol Exp Ther; 1996 Mar; 276(3):1078-88. PubMed ID: 8786538
    [Abstract] [Full Text] [Related]

  • 2. The complex of FK506-binding protein 12 and FK506 inhibits calcineurin phosphatase activity and IgE activation-induced cytokine transcripts, but not exocytosis, in mouse mast cells.
    Fruman DA, Bierer BE, Benes JE, Burakoff SJ, Austen KF, Katz HR.
    J Immunol; 1995 Feb 15; 154(4):1846-51. PubMed ID: 7530743
    [Abstract] [Full Text] [Related]

  • 3. The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin.
    Dumont FJ, Staruch MJ, Koprak SL, Siekierka JJ, Lin CS, Harrison R, Sewell T, Kindt VM, Beattie TR, Wyvratt M.
    J Exp Med; 1992 Sep 01; 176(3):751-60. PubMed ID: 1380976
    [Abstract] [Full Text] [Related]

  • 4. Quantitative and temporal analysis of the cellular interaction of FK-506 and rapamycin in T-lymphocytes.
    Dumont FJ, Kastner C, Iacovone F, Fischer PA.
    J Pharmacol Exp Ther; 1994 Jan 01; 268(1):32-41. PubMed ID: 7507994
    [Abstract] [Full Text] [Related]

  • 5. Depletion of the mature CD4+8- thymocyte subset by FK506 analogs correlates with their immunosuppressive and calcineurin inhibitory activities.
    Koprak S, Sirotina A, Ok H, Dumont FJ.
    Transplantation; 1996 Mar 27; 61(6):926-32. PubMed ID: 8623162
    [Abstract] [Full Text] [Related]

  • 6. Everolimus and sirolimus antagonize tacrolimus based calcineurin inhibition via competition for FK-binding protein 12.
    van Rossum HH, Romijn FP, Smit NP, de Fijter JW, van Pelt J.
    Biochem Pharmacol; 2009 Apr 01; 77(7):1206-12. PubMed ID: 19154728
    [Abstract] [Full Text] [Related]

  • 7. Use of mixed lymphocyte reaction to identify subimmunosuppressive FK-506 levels in mice.
    Ellis RA, Brenner MJ, Mackinnon SE, Myckatyn TM, Hunter DA.
    Microsurgery; 2003 Apr 01; 23(3):276-82. PubMed ID: 12833332
    [Abstract] [Full Text] [Related]

  • 8. Immunosuppressive effect of leukotriene B(4) receptor antagonist in vitro.
    Morita H, Takeda K, Yagita H, Okumura K.
    Biochem Biophys Res Commun; 1999 Oct 22; 264(2):321-6. PubMed ID: 10529362
    [Abstract] [Full Text] [Related]

  • 9. Mode of action of FK-506 on protective immunity to Hymenolepis nana in mice.
    Asano K, Taki M, Matsuo S, Yamada K.
    In Vivo; 1996 Oct 22; 10(6):537-45. PubMed ID: 8986461
    [Abstract] [Full Text] [Related]

  • 10. Calcineurin mutants render T lymphocytes resistant to cyclosporin A.
    Zhu D, Cardenas ME, Heitman J.
    Mol Pharmacol; 1996 Sep 22; 50(3):506-11. PubMed ID: 8794888
    [Abstract] [Full Text] [Related]

  • 11. Immunophilins may limit calcineurin inhibition by cyclosporine and tacrolimus at high drug concentrations.
    Kung L, Halloran PF.
    Transplantation; 2000 Jul 27; 70(2):327-35. PubMed ID: 10933159
    [Abstract] [Full Text] [Related]

  • 12. Comparative analysis of calcineurin inhibition by complexes of immunosuppressive drugs with human FK506 binding proteins.
    Weiwad M, Edlich F, Kilka S, Erdmann F, Jarczowski F, Dorn M, Moutty MC, Fischer G.
    Biochemistry; 2006 Dec 26; 45(51):15776-84. PubMed ID: 17176100
    [Abstract] [Full Text] [Related]

  • 13. Suppressive effect of a novel water-soluble artemisinin derivative SM905 on T cell activation and proliferation in vitro and in vivo.
    Wang JX, Tang W, Yang ZS, Wan J, Shi LP, Zhang Y, Zhou R, Ni J, Hou LF, Zhou Y, He PL, Yang YF, Li Y, Zuo JP.
    Eur J Pharmacol; 2007 Jun 14; 564(1-3):211-8. PubMed ID: 17349993
    [Abstract] [Full Text] [Related]

  • 14. Inhibition of calcineurin by a novel FK-506-binding protein.
    Sewell TJ, Lam E, Martin MM, Leszyk J, Weidner J, Calaycay J, Griffin P, Williams H, Hung S, Cryan J.
    J Biol Chem; 1994 Aug 19; 269(33):21094-102. PubMed ID: 7520438
    [Abstract] [Full Text] [Related]

  • 15. Evaluation for synergistic suppression of T cell responses to minor histocompatibility antigens by chloroquine in combination with tacrolimus and a rapamycin derivative, SDZ-RAD.
    Hsiao CC, Su WN, Forooghian F, Bader S, Rempel J, HayGlass KT, Gilman A, Schultz KR.
    Bone Marrow Transplant; 2002 Dec 19; 30(12):905-13. PubMed ID: 12476284
    [Abstract] [Full Text] [Related]

  • 16. Inhibition by the immunosuppressive agent FK-506 of antigen-induced airways eosinophilia and bronchial hyperreactivity in mice.
    Eum SY, Zuany-Amorim C, Lefort J, Pretolani M, Vargaftig BB.
    Br J Pharmacol; 1997 Jan 19; 120(1):130-6. PubMed ID: 9117088
    [Abstract] [Full Text] [Related]

  • 17. The 5-HT3 receptor antagonist tropisetron inhibits T cell activation by targeting the calcineurin pathway.
    Vega Lde L, Muñoz E, Calzado MA, Lieb K, Candelario-Jalil E, Gschaidmeir H, Färber L, Mueller W, Stratz T, Fiebich BL.
    Biochem Pharmacol; 2005 Aug 01; 70(3):369-80. PubMed ID: 15922994
    [Abstract] [Full Text] [Related]

  • 18. In vitro immunosuppressive activity, isolation from pig liver microsomes and identification by electrospray ms-ms of a new FK-506 C19-C20 epoxide metabolite.
    Lhoëst G, Dieden R, Verbeeck RK, Maton N, Ingendoh A, Latinne D.
    J Pharmacol Exp Ther; 1998 Mar 01; 284(3):1074-81. PubMed ID: 9495869
    [Abstract] [Full Text] [Related]

  • 19. The novel calcineurin inhibitor ISA247: a more potent immunosuppressant than cyclosporine in vitro.
    Bîrsan T, Dambrin C, Freitag DG, Yatscoff RW, Morris RE.
    Transpl Int; 2005 May 01; 17(12):767-71. PubMed ID: 15827754
    [Abstract] [Full Text] [Related]

  • 20. The FKBP-associated protein FAP48 is an antiproliferative molecule and a player in T cell activation that increases IL2 synthesis.
    Krummrei U, Baulieu EE, Chambraud B.
    Proc Natl Acad Sci U S A; 2003 Mar 04; 100(5):2444-9. PubMed ID: 12604780
    [Abstract] [Full Text] [Related]

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