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865 related items for PubMed ID: 8801059

  • 1. Conjugation of glutathione with a toxic metabolite of valproic acid, (E)-2-propyl-2,4-pentadienoic acid, catalyzed by rat hepatic glutathione-S-transferases.
    Tang W, Borel AG, Abbott FS.
    Drug Metab Dispos; 1996 Apr; 24(4):436-46. PubMed ID: 8801059
    [Abstract] [Full Text] [Related]

  • 2. Bioactivation of a toxic metabolite of valproic acid, (E)-2-propyl-2,4-pentadienoic acid, via glucuronidation. LC/MS/MS characterization of the GSH-glucuronide diconjugates.
    Tang W, Abbott FS.
    Chem Res Toxicol; 1996 Mar; 9(2):517-26. PubMed ID: 8839057
    [Abstract] [Full Text] [Related]

  • 3. Identification and characterization of the glutathione and N-acetylcysteine conjugates of (E)-2-propyl-2,4-pentadienoic acid, a toxic metabolite of valproic acid, in rats and humans.
    Kassahun K, Farrell K, Abbott F.
    Drug Metab Dispos; 1991 Mar; 19(2):525-35. PubMed ID: 1676665
    [Abstract] [Full Text] [Related]

  • 4. Identification in rat bile of glutathione conjugates of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether, a nephrotoxic degradate of the anesthetic agent sevoflurane.
    Jin L, Davis MR, Kharasch ED, Doss GA, Baillie TA.
    Chem Res Toxicol; 1996 Mar; 9(2):555-61. PubMed ID: 8839062
    [Abstract] [Full Text] [Related]

  • 5. Formation and biliary excretion of glutathione conjugates of bile acids in the rat as shown by liquid chromatography/electrospray ionization-linear ion trap mass spectrometry.
    Mitamura K, Watanabe S, Mitsumoto Y, Sakai T, Sogabe M, Wakamiya T, Ikegawa S.
    Anal Biochem; 2009 Jan 15; 384(2):224-30. PubMed ID: 18938128
    [Abstract] [Full Text] [Related]

  • 6. Assessment of the role of in situ generated (E)-2,4-diene-valproic acid in the toxicity of valproic acid and (E)-2-ene-valproic acid in sandwich-cultured rat hepatocytes.
    Surendradoss J, Chang TK, Abbott FS.
    Toxicol Appl Pharmacol; 2012 Nov 01; 264(3):413-22. PubMed ID: 22940460
    [Abstract] [Full Text] [Related]

  • 7. Identification and characterization of N-acetylcysteine conjugates of valproic acid in humans and animals.
    Gopaul SV, Farrell K, Abbott FS.
    Drug Metab Dispos; 2000 Jul 01; 28(7):823-32. PubMed ID: 10859157
    [Abstract] [Full Text] [Related]

  • 8. Glutathione S-transferase conjugation of organophosphorus pesticides yields S-phospho-, S-aryl-, and S-alkylglutathione derivatives.
    Fujioka K, Casida JE.
    Chem Res Toxicol; 2007 Aug 01; 20(8):1211-7. PubMed ID: 17645302
    [Abstract] [Full Text] [Related]

  • 9. Characterization of thiol-conjugated metabolites of 2-propylpent-4-enoic acid (4-ene VPA), a toxic metabolite of valproic acid, by electrospray tandem mass spectrometry.
    Tang W, Abbott FS.
    J Mass Spectrom; 1996 Aug 01; 31(8):926-36. PubMed ID: 8799319
    [Abstract] [Full Text] [Related]

  • 10. Interaction of the electrophilic ketoprofenyl-glucuronide and ketoprofenyl-coenzyme A conjugates with cytosolic glutathione S-transferases.
    Osbild S, Bour J, Maunit B, Guillaume C, Asensio C, Muller JF, Netter P, Kirsch G, Bagrel D, Lapicque F, Battaglia E.
    Drug Metab Dispos; 2008 Feb 01; 36(2):260-7. PubMed ID: 17962374
    [Abstract] [Full Text] [Related]

  • 11. Glutathione transferase theta 1-1-dependent metabolism of the water disinfection byproduct bromodichloromethane.
    Ross MK, Pegram RA.
    Chem Res Toxicol; 2003 Feb 01; 16(2):216-26. PubMed ID: 12588193
    [Abstract] [Full Text] [Related]

  • 12. Stereo- and regioselective conjugation of S-halovinyl mercapturic acid sulfoxides by glutathione S-transferases.
    Rosner E, Müller M, Dekant W.
    Chem Res Toxicol; 1998 Jan 01; 11(1):12-8. PubMed ID: 9477221
    [Abstract] [Full Text] [Related]

  • 13. Enzymatic and nonenzymatic synthesis of glutathione conjugates: application to the understanding of a parasite's defense system and alternative to the discovery of potent glutathione S-transferase inhibitors.
    Lo WJ, Chiou YC, Hsu YT, Lam WS, Chang MY, Jao SC, Li WS.
    Bioconjug Chem; 2007 Jan 01; 18(1):109-20. PubMed ID: 17226963
    [Abstract] [Full Text] [Related]

  • 14. Metabolic activation of unsaturated derivatives of valproic acid. Identification of novel glutathione adducts formed through coenzyme A-dependent and -independent processes.
    Kassahun K, Hu P, Grillo MP, Davis MR, Jin L, Baillie TA.
    Chem Biol Interact; 1994 Mar 01; 90(3):253-75. PubMed ID: 8168173
    [Abstract] [Full Text] [Related]

  • 15. Cytochrome P-450-mediated dehydrogenation of 2-n-propyl-2(E)-pentenoic acid, a pharmacologically-active metabolite of valproic acid, in rat liver microsomal preparations.
    Kassahun K, Baillie TA.
    Drug Metab Dispos; 1993 Mar 01; 21(2):242-8. PubMed ID: 8097692
    [Abstract] [Full Text] [Related]

  • 16. The role of human glutathione S-transferase isoenzymes in the formation of glutathione conjugates of the alkylating cytostatic drug thiotepa.
    Dirven HA, Dictus EL, Broeders NL, van Ommen B, van Bladeren PJ.
    Cancer Res; 1995 Apr 15; 55(8):1701-6. PubMed ID: 7712478
    [Abstract] [Full Text] [Related]

  • 17. Glutathione S-transferase-catalyzed conjugation of bioactivated aflatoxin B1 in rabbit lung and liver.
    Stewart RK, Serabjit-Singh CJ, Massey TE.
    Toxicol Appl Pharmacol; 1996 Oct 15; 140(2):499-507. PubMed ID: 8887467
    [Abstract] [Full Text] [Related]

  • 18. A mechanism of inhibition of aflatoxin B1-DNA binding in the liver by phenobarbital pretreatment of rats.
    Lotlikar PD, Raj HG, Bohm LS, Ho LL, Jhee EC, Tsuji K, Gopalan P.
    Cancer Res; 1989 Feb 15; 49(4):951-7. PubMed ID: 2492210
    [Abstract] [Full Text] [Related]

  • 19. Enzymatic conjugation of hexachloro-1,3-butadiene with glutathione. Formation of 1-(glutathion-S-yl)-1,2,3,4,4-pentachlorobuta-1,3-diene and 1,4-bis(glutathion-S-yl)-1,2,3,4-tetrachlorobuta-1,3-diene.
    Dekant W, Vamvakas S, Henschler D, Anders MW.
    Drug Metab Dispos; 1988 Feb 15; 16(5):701-6. PubMed ID: 2906593
    [Abstract] [Full Text] [Related]

  • 20. Glutathione conjugation of trichloroethylene in rats and mice: sex-, species-, and tissue-dependent differences.
    Lash LH, Qian W, Putt DA, Jacobs K, Elfarra AA, Krause RJ, Parker JC.
    Drug Metab Dispos; 1998 Jan 15; 26(1):12-9. PubMed ID: 9443846
    [Abstract] [Full Text] [Related]

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