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Journal Abstract Search

114 related items for PubMed ID: 8824218

  • 1. Secobarbital-mediated inactivation of cytochrome P450 2B1 and its active site mutants. Partitioning between heme and protein alkylation and epoxidation.
    He K, He YA, Szklarz GD, Halpert JR, Correia MA.
    J Biol Chem; 1996 Oct 18; 271(42):25864-72. PubMed ID: 8824218
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  • 2. Identification of the heme adduct and an active site peptide modified during mechanism-based inactivation of rat liver cytochrome P450 2B1 by secobarbital.
    He K, Falick AM, Chen B, Nilsson F, Correia MA.
    Chem Res Toxicol; 1996 Oct 18; 9(3):614-22. PubMed ID: 8728507
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  • 3. Identification of amino acid residues involved in the inactivation of cytochrome P450 2B1 by two acetylenic compounds: the role of three residues in nonsubstrate recognition Sites.
    Von Weymarn LB, Sridar C, Hollenberg PF.
    J Pharmacol Exp Ther; 2004 Oct 18; 311(1):71-9. PubMed ID: 15178696
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  • 4. Secobarbital-mediated inactivation of rat liver cytochrome P-450b: a mechanistic reappraisal.
    Lunetta JM, Sugiyama K, Correia MA.
    Mol Pharmacol; 1989 Jan 18; 35(1):10-7. PubMed ID: 2913483
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  • 5. Identification of 17-alpha-ethynylestradiol-modified active site peptides and glutathione conjugates formed during metabolism and inactivation of P450s 2B1 and 2B6.
    Kent UM, Lin HL, Mills DE, Regal KA, Hollenberg PF.
    Chem Res Toxicol; 2006 Feb 18; 19(2):279-87. PubMed ID: 16485904
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  • 6. Inactivation of cytochrome P450 2B1 by benzyl isothiocyanate, a chemopreventative agent from cruciferous vegetables.
    Goosen TC, Kent UM, Brand L, Hollenberg PF.
    Chem Res Toxicol; 2000 Dec 18; 13(12):1349-59. PubMed ID: 11123978
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  • 10. Mechanism-based inactivation of cytochrome P450 2B1 by 7-ethynylcoumarin: verification of apo-P450 adduction by electrospray ion trap mass spectrometry.
    Regal KA, Schrag ML, Kent UM, Wienkers LC, Hollenberg PF.
    Chem Res Toxicol; 2000 Apr 18; 13(4):262-70. PubMed ID: 10775326
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  • 11. The functional role of threonine-205 in the mechanism-based inactivation of P450 2B1 by two ethynyl substrates: the importance of the F helix in catalysis.
    Lin HL, Kent UM, Zhang H, Waskell L, Hollenberg PF.
    J Pharmacol Exp Ther; 2004 Dec 18; 311(3):855-63. PubMed ID: 15302894
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  • 14. Effect of 17-alpha-ethynylestradiol on activities of cytochrome P450 2B (P450 2B) enzymes: characterization of inactivation of P450s 2B1 and 2B6 and identification of metabolites.
    Kent UM, Mills DE, Rajnarayanan RV, Alworth WL, Hollenberg PF.
    J Pharmacol Exp Ther; 2002 Feb 18; 300(2):549-58. PubMed ID: 11805216
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  • 16. Mechanism-based inactivation of cytochrome P450 2B1 by 2-ethynylnaphthalene: identification of an active-site peptide.
    Roberts ES, Hopkins NE, Alworth WL, Hollenberg PF.
    Chem Res Toxicol; 1993 Feb 18; 6(4):470-9. PubMed ID: 8374044
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  • 18. A rational approach to Re-engineer cytochrome P450 2B1 regioselectivity based on the crystal structure of cytochrome P450 2C5.
    Kumar S, Scott EE, Liu H, Halpert JR.
    J Biol Chem; 2003 May 09; 278(19):17178-84. PubMed ID: 12609983
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