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413 related items for PubMed ID: 8839062

  • 1. Identification in rat bile of glutathione conjugates of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether, a nephrotoxic degradate of the anesthetic agent sevoflurane.
    Jin L, Davis MR, Kharasch ED, Doss GA, Baillie TA.
    Chem Res Toxicol; 1996 Mar; 9(2):555-61. PubMed ID: 8839062
    [Abstract] [Full Text] [Related]

  • 2. Glutathione S-conjugation of the sevoflurane degradation product, fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human liver, kidney, and blood in vitro.
    Altuntas TG, Kharasch ED.
    Toxicol Appl Pharmacol; 2001 Dec 01; 177(2):85-93. PubMed ID: 11740907
    [Abstract] [Full Text] [Related]

  • 3. Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats.
    Sheffels P, Schroeder JL, Altuntas TG, Liggitt HD, Kharasch ED.
    Chem Res Toxicol; 2004 Sep 01; 17(9):1177-89. PubMed ID: 15377151
    [Abstract] [Full Text] [Related]

  • 4. Dose-dependent metabolism of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), an anesthetic degradation product, to mercapturic acids and 3,3,3-trifluoro-2-(fluoromethoxy)propanoic acid in rats.
    Kharasch ED, Jubert C, Spracklin DK, Hoffman GM.
    Toxicol Appl Pharmacol; 1999 Oct 01; 160(1):49-59. PubMed ID: 10502502
    [Abstract] [Full Text] [Related]

  • 5. Evidence for metabolism of fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), a sevoflurane degradation product, by cysteine conjugate beta-lyase.
    Spracklin DK, Kharasch ED.
    Chem Res Toxicol; 1996 Jun 01; 9(4):696-702. PubMed ID: 8831812
    [Abstract] [Full Text] [Related]

  • 6. Sulfoxidation of cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A).
    Altuntas TG, Park SB, Kharasch ED.
    Chem Res Toxicol; 2004 Mar 01; 17(3):435-45. PubMed ID: 15025515
    [Abstract] [Full Text] [Related]

  • 7. Nephrotoxicity of the glutathione and cysteine S-conjugates of the sevoflurane degradation product 2-(fluoromethoxy)-1,1,3,3, 3-pentafluoro-1-propene (Compound A) in male Fischer 344 rats.
    Iyer RA, Baggs RB, Anders MW.
    J Pharmacol Exp Ther; 1997 Dec 01; 283(3):1544-51. PubMed ID: 9400032
    [Abstract] [Full Text] [Related]

  • 8. Cytotoxicity of S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl) vinyl ether (Compound A) in a human proximal tubular cell line.
    Altuntas TG, Zager RA, Kharasch ED.
    Toxicol Appl Pharmacol; 2003 Nov 15; 193(1):55-65. PubMed ID: 14613716
    [Abstract] [Full Text] [Related]

  • 9. Nephrotoxicity of sevoflurane compound A [fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether] in rats: evidence for glutathione and cysteine conjugate formation and the role of renal cysteine conjugate beta-lyase.
    Jin L, Baillie TA, Davis MR, Kharasch ED.
    Biochem Biophys Res Commun; 1995 May 16; 210(2):498-506. PubMed ID: 7755627
    [Abstract] [Full Text] [Related]

  • 10. Cysteine conjugate beta-lyase-dependent biotransformation of the cysteine S-conjugates of the sevoflurane degradation product 2-(fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (compound A).
    Iyer RA, Anders MW.
    Chem Res Toxicol; 1997 Jul 16; 10(7):811-9. PubMed ID: 9250416
    [Abstract] [Full Text] [Related]

  • 11. Biotransformation of L-cysteine S-conjugates and N-acetyl-L-cysteine S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human kidney in vitro: interindividual variability in N-acetylation, N-deacetylation, and beta-lyase-catalyzed metabolism.
    Gul Altuntas T, Kharasch ED.
    Drug Metab Dispos; 2002 Feb 16; 30(2):148-54. PubMed ID: 11792683
    [Abstract] [Full Text] [Related]

  • 12. Conjugation of glutathione with a toxic metabolite of valproic acid, (E)-2-propyl-2,4-pentadienoic acid, catalyzed by rat hepatic glutathione-S-transferases.
    Tang W, Borel AG, Abbott FS.
    Drug Metab Dispos; 1996 Apr 16; 24(4):436-46. PubMed ID: 8801059
    [Abstract] [Full Text] [Related]

  • 13. P450-dependent and nonenzymatic human liver microsomal defluorination of fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A), a sevoflurane degradation product.
    Kharasch ED, Hankins DC.
    Drug Metab Dispos; 1996 Jun 16; 24(6):649-54. PubMed ID: 8781780
    [Abstract] [Full Text] [Related]

  • 14. Metabolism of the chemoprotective agent diallyl sulfide to glutathione conjugates in rats.
    Jin L, Baillie TA.
    Chem Res Toxicol; 1997 Mar 16; 10(3):318-27. PubMed ID: 9084912
    [Abstract] [Full Text] [Related]

  • 15. Formation and biliary excretion of glutathione conjugates of bile acids in the rat as shown by liquid chromatography/electrospray ionization-linear ion trap mass spectrometry.
    Mitamura K, Watanabe S, Mitsumoto Y, Sakai T, Sogabe M, Wakamiya T, Ikegawa S.
    Anal Biochem; 2009 Jan 15; 384(2):224-30. PubMed ID: 18938128
    [Abstract] [Full Text] [Related]

  • 16. Gene expression profiling of nephrotoxicity from the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether ("compound A") in rats.
    Kharasch ED, Schroeder JL, Bammler T, Beyer R, Srinouanprachanh S.
    Toxicol Sci; 2006 Apr 15; 90(2):419-31. PubMed ID: 16384817
    [Abstract] [Full Text] [Related]

  • 17. Identification of bile acid S-acyl glutathione conjugates in rat bile by liquid chromatography/electrospray ionization-linear ion trap mass spectrometry.
    Mitamura K, Hori N, Iida T, Hofmann AF, Ikegawa S.
    Steroids; 2011 Jan 15; 76(1-2):68-77. PubMed ID: 20837038
    [Abstract] [Full Text] [Related]

  • 18. Determination of enzyme kinetics and glutathione conjugates of chlortetracycline and chloroacetanilides using liquid chromatography-mass spectrometry.
    Farkas M, Berry JO, Aga DS.
    Analyst; 2007 Jul 15; 132(7):664-71. PubMed ID: 17592585
    [Abstract] [Full Text] [Related]

  • 19. Bioactivation of a toxic metabolite of valproic acid, (E)-2-propyl-2,4-pentadienoic acid, via glucuronidation. LC/MS/MS characterization of the GSH-glucuronide diconjugates.
    Tang W, Abbott FS.
    Chem Res Toxicol; 1996 Mar 15; 9(2):517-26. PubMed ID: 8839057
    [Abstract] [Full Text] [Related]

  • 20. Glutathione S-transferase conjugation of organophosphorus pesticides yields S-phospho-, S-aryl-, and S-alkylglutathione derivatives.
    Fujioka K, Casida JE.
    Chem Res Toxicol; 2007 Aug 15; 20(8):1211-7. PubMed ID: 17645302
    [Abstract] [Full Text] [Related]

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