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292 related items for PubMed ID: 8855937

  • 1. Nonpolar interactions of thrombin and its inhibitors at the fibrinogen recognition exosite: thermodynamic analysis.
    Cheng Y, Slon-Usakiewicz JJ, Wang J, Purisima EO, Konishi Y.
    Biochemistry; 1996 Oct 08; 35(40):13021-9. PubMed ID: 8855937
    [Abstract] [Full Text] [Related]

  • 2. Calculation of relative binding free energies and configurational entropies: a structural and thermodynamic analysis of the nature of non-polar binding of thrombin inhibitors based on hirudin55-65.
    Wang J, Szewczuk Z, Yue SY, Tsuda Y, Konishi Y, Purisima EO.
    J Mol Biol; 1995 Oct 27; 253(3):473-92. PubMed ID: 7473728
    [Abstract] [Full Text] [Related]

  • 3. Design of P1' and P3' residues of trivalent thrombin inhibitors and their crystal structures.
    Slon-Usakiewicz JJ, Sivaraman J, Li Y, Cygler M, Konishi Y.
    Biochemistry; 2000 Mar 07; 39(9):2384-91. PubMed ID: 10694407
    [Abstract] [Full Text] [Related]

  • 4. Interactions of hirudin-based inhibitor with thrombin: critical role of the IleH59 side chain of the inhibitor.
    Tsuda Y, Szewczuk Z, Wang J, Yue SY, Purisima E, Konishi Y.
    Biochemistry; 1995 Jul 11; 34(27):8708-14. PubMed ID: 7612610
    [Abstract] [Full Text] [Related]

  • 5. Electrostatic steering and ionic tethering in the formation of thrombin-hirudin complexes: the role of the thrombin anion-binding exosite-I.
    Myles T, Le Bonniec BF, Betz A, Stone SR.
    Biochemistry; 2001 Apr 24; 40(16):4972-9. PubMed ID: 11305913
    [Abstract] [Full Text] [Related]

  • 6. Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6.
    Zdanov A, Wu S, DiMaio J, Konishi Y, Li Y, Wu X, Edwards BF, Martin PD, Cygler M.
    Proteins; 1993 Nov 24; 17(3):252-65. PubMed ID: 8272424
    [Abstract] [Full Text] [Related]

  • 7. Synthesis and characterization of more potent analogues of hirudin fragment 1-47 containing non-natural amino acids.
    De Filippis V, Quarzago D, Vindigni A, Di Cera E, Fontana A.
    Biochemistry; 1998 Sep 29; 37(39):13507-15. PubMed ID: 9753436
    [Abstract] [Full Text] [Related]

  • 8. Allosteric changes of thrombin catalytic site induced by interaction of bothrojaracin with anion-binding exosites I and II.
    Monteiro RQ, Rapôso JG, Wisner A, Guimarães JA, Bon C, Zingali RB.
    Biochem Biophys Res Commun; 1999 Sep 07; 262(3):819-22. PubMed ID: 10471408
    [Abstract] [Full Text] [Related]

  • 9. Hirudin C-terminal fragments inhibit thrombin induced neutrophil chemotaxis.
    Rowand JK, Marucha P, Berliner LJ.
    Thromb Haemost; 1992 Mar 02; 67(3):289-91. PubMed ID: 1641817
    [Abstract] [Full Text] [Related]

  • 10. Structure-activity relationships of recombinant hirudins.
    Stürzebecher J, Walsmann P.
    Semin Thromb Hemost; 1991 Apr 02; 17(2):94-8. PubMed ID: 1771418
    [Abstract] [Full Text] [Related]

  • 11. Structural and Functional Characterization of Hirudin P6 Derived Novel Bivalent Thrombin Inhibitors - Studying the Effect of Linker Length and Glycosylation on Their Function.
    Shabareesh P, Kaur KJ.
    Chem Biol Drug Des; 2016 Jul 02; 88(1):129-41. PubMed ID: 26850929
    [Abstract] [Full Text] [Related]

  • 12. The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin.
    Vijayalakshmi J, Padmanabhan KP, Mann KG, Tulinsky A.
    Protein Sci; 1994 Dec 02; 3(12):2254-71. PubMed ID: 7756983
    [Abstract] [Full Text] [Related]

  • 13. Characterization of the interactions of a bifunctional inhibitor with alpha-thrombin by molecular modelling and peptide synthesis.
    Yue SY, DiMaio J, Szewczuk Z, Purisima EO, Ni F, Konishi Y.
    Protein Eng; 1992 Jan 02; 5(1):77-85. PubMed ID: 1631048
    [Abstract] [Full Text] [Related]

  • 14. Molecular dynamics simulations of thrombin inhibitors at the S' subsites of thrombin.
    Yue SY, Konishi Y.
    Drug Des Discov; 1994 Jul 02; 12(1):1-17. PubMed ID: 7578804
    [Abstract] [Full Text] [Related]

  • 15. Hirunorms are true hirudin mimetics. The crystal structure of human alpha-thrombin-hirunorm V complex.
    De Simone G, Lombardi A, Galdiero S, Nastri F, Della Morte R, Staiano N, Pedone C, Bolognesi M, Pavone V.
    Protein Sci; 1998 Feb 02; 7(2):243-53. PubMed ID: 9521099
    [Abstract] [Full Text] [Related]

  • 16. Probing the hirudin-thrombin interaction by incorporation of noncoded amino acids and molecular dynamics simulation.
    De Filippis V, Colombo G, Russo I, Spadari B, Fontana A.
    Biochemistry; 2002 Nov 19; 41(46):13556-69. PubMed ID: 12427016
    [Abstract] [Full Text] [Related]

  • 17. Thermodynamic investigation of hirudin binding to the slow and fast forms of thrombin: evidence for folding transitions in the inhibitor and protease coupled to binding.
    Ayala YM, Vindigni A, Nayal M, Spolar RS, Record MT, Di Cera E.
    J Mol Biol; 1995 Nov 10; 253(5):787-98. PubMed ID: 7473752
    [Abstract] [Full Text] [Related]

  • 18. Nonpolar interactions of thrombin S' subsites with its bivalent inhibitor: methyl scan of the inhibitor linker.
    Slon-Usakiewicz JJ, Purisima E, Tsuda Y, Sulea T, Pedyczak A, Féthière J, Cygler M, Konishi Y.
    Biochemistry; 1997 Nov 04; 36(44):13494-502. PubMed ID: 9354617
    [Abstract] [Full Text] [Related]

  • 19. Thrombin-bound conformation of the C-terminal fragments of hirudin determined by transferred nuclear Overhauser effects.
    Ni F, Konishi Y, Scheraga HA.
    Biochemistry; 1990 May 08; 29(18):4479-89. PubMed ID: 2350549
    [Abstract] [Full Text] [Related]

  • 20. Release of fibrinopeptides by the slow and fast forms of thrombin.
    Vindigni A, Di Cera E.
    Biochemistry; 1996 Apr 09; 35(14):4417-26. PubMed ID: 8605191
    [Abstract] [Full Text] [Related]

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