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Journal Abstract Search


68 related items for PubMed ID: 8863276

  • 1. Improvement of intestinal absorption of leucine enkephalin by sugar coupling and peptidase inhibitors.
    Mizuma T, Ohta K, Koyanagi A, Awazu S.
    J Pharm Sci; 1996 Aug; 85(8):854-7. PubMed ID: 8863276
    [Abstract] [Full Text] [Related]

  • 2. Peripherally active analgesia of aminopeptidase-resistant sugar-coupled leucine enkephalin.
    Mizuma T, Ohta K, Awazu S.
    Res Commun Mol Pathol Pharmacol; 1997 Jan; 95(1):83-91. PubMed ID: 9055351
    [Abstract] [Full Text] [Related]

  • 3. Intestinal absorption and analgesic activity of aminopeptidase-resistant cellobiose-coupled leucine enkephalinamide.
    Mizuma T, Ohta K, Awazu S.
    Biopharm Drug Dispos; 1998 Dec; 19(9):605-10. PubMed ID: 9872343
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  • 7. Effects of various protease inhibitors on the stability and permeability of [D-Ala2,D-Leu5]enkephalin in the rat intestine: comparison with leucine enkephalin.
    Uchiyama T, Kotani A, Kishida T, Tatsumi H, Okamoto A, Fujita T, Murakami M, Muranishi S, Yamamoto A.
    J Pharm Sci; 1998 Apr; 87(4):448-52. PubMed ID: 9548897
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  • 8. Transport kinetics of leucine enkephalin across Caco-2 monolayers: quantitative analysis for contribution of enzymatic and transport barrier.
    Quan YS, Fujita T, Tohara D, Tsuji M, Kohyama M, Yamamoto A.
    Life Sci; 1999 Apr; 64(14):1243-52. PubMed ID: 10210267
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  • 9. Intestinal transport and metabolism of analgesic dipeptide, kyotorphin: rate-limiting factor in intestinal absorption of peptide as drug.
    Mizuma T, Koyanagi A, Awazu S.
    Biochim Biophys Acta; 1997 Apr 17; 1335(1-2):111-9. PubMed ID: 9133647
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  • 10. Nasal absorption of leucine enkephalin in rats and the effects of aminopeptidase inhibition, as determined from the percentage of the dose unabsorbed.
    Hussain MA, Aungst BJ.
    Pharm Res; 1992 Oct 17; 9(10):1362-4. PubMed ID: 1448440
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  • 11. An in vitro evaluation of metabolism and poor membrane permeation impeding intestinal absorption of leucine enkephalin, and methods to increase absorption.
    Aungst BJ, Blake JA, Hussain MA.
    J Pharmacol Exp Ther; 1991 Oct 17; 259(1):139-45. PubMed ID: 1920113
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  • 12. Hepatic inactivation of Leu-enkephalin.
    MacKinnon KL, Zuzel KA, Billington D.
    Regul Pept; 1996 Dec 03; 67(2):85-92. PubMed ID: 8958578
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  • 13. Gastrointestinal absorption of peptide drug: quantitative evaluation of the degradation and the permeation of metkephamid in rat small intestine.
    Taki Y, Sakane T, Nadai T, Sezaki H, Amidon GL, Langguth P, Yamashita S.
    J Pharmacol Exp Ther; 1995 Jul 03; 274(1):373-7. PubMed ID: 7616421
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  • 14. Characterization of hydrolysis of [leu]enkephalin and D-ala2-[L-leu]enkephalin in rat plasma.
    Weinberger SB, Martinez JL.
    J Pharmacol Exp Ther; 1988 Oct 03; 247(1):129-35. PubMed ID: 2902210
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  • 15. Comparative study of active absorption by the intestine and disposition of anomers of sugar-conjugated compounds.
    Mizuma T, Ohta K, Hayashi M, Awazu S.
    Biochem Pharmacol; 1993 Apr 06; 45(7):1520-3. PubMed ID: 8471074
    [Abstract] [Full Text] [Related]

  • 16. The Metabolic Inhibition Model Which Predicts the Intestinal Absorbability and Metabolizability of Drug: Theory and Experiment.
    Mizuma T, Awazu S.
    Biol Proced Online; 1998 May 14; 1():32-39. PubMed ID: 12734588
    [Abstract] [Full Text] [Related]

  • 17. Potential utility of various protease inhibitors for improving the intestinal absorption of insulin in rats.
    Liu H, Tang R, Pan WS, Zhang Y, Liu H.
    J Pharm Pharmacol; 2003 Nov 14; 55(11):1523-9. PubMed ID: 14713363
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  • 18. [Effects of protease inhibitors on intestinal absorption of insulin].
    Liu H, Pan WS, Du R, Li XD, Tang R.
    Yao Xue Xue Bao; 2004 Feb 14; 39(2):140-3. PubMed ID: 15127624
    [Abstract] [Full Text] [Related]

  • 19. Intestinal transport and metabolism of glucose-conjugated kyotorphin and cyclic kyotorphin: metabolic degradation is crucial to intestinal absorption of peptide drugs.
    Mizuma T, Koyanagi A, Awazu S.
    Biochim Biophys Acta; 2000 Jun 01; 1475(1):90-8. PubMed ID: 10806343
    [Abstract] [Full Text] [Related]

  • 20. Increase in antinociceptive effect of [leu5]enkephalin after intrathecal administration of mixture of three peptidase inhibitors.
    Miura M, Yoshikawa M, Watanabe M, Takahashi S, Ajimi J, Ito K, Ito M, Kawaguchi M, Kobayashi H, Suzuki T.
    Tokai J Exp Clin Med; 2013 Jul 20; 38(2):62-70. PubMed ID: 23868737
    [Abstract] [Full Text] [Related]


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