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494 related items for PubMed ID: 8863816
1. Expression of human NAD(P)H: quinone oxidoreductase (DT-diaphorase) in Chinese hamster ovary cells: effect on the toxicity of antitumor quinones. Gustafson DL, Beall HD, Bolton EM, Ross D, Waldren CA. Mol Pharmacol; 1996 Oct; 50(4):728-35. PubMed ID: 8863816 [Abstract] [Full Text] [Related]
2. Nicotinamide adenine dinucleotide (phosphate): quinone oxidoreductase (DT-diaphorase) as a target for bioreductive antitumor quinones: quinone cytotoxicity and selectivity in human lung and breast cancer cell lines. Beall HD, Murphy AM, Siegel D, Hargreaves RH, Butler J, Ross D. Mol Pharmacol; 1995 Sep; 48(3):499-504. PubMed ID: 7565631 [Abstract] [Full Text] [Related]
3. Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones. Winski SL, Swann E, Hargreaves RH, Dehn DL, Butler J, Moody CJ, Ross D. Biochem Pharmacol; 2001 Jun 15; 61(12):1509-16. PubMed ID: 11377380 [Abstract] [Full Text] [Related]
4. Reductase enzyme expression across the National Cancer Institute Tumor cell line panel: correlation with sensitivity to mitomycin C and EO9. Fitzsimmons SA, Workman P, Grever M, Paull K, Camalier R, Lewis AD. J Natl Cancer Inst; 1996 Mar 06; 88(5):259-69. PubMed ID: 8614004 [Abstract] [Full Text] [Related]
5. Establishment of an isogenic human colon tumor model for NQO1 gene expression: application to investigate the role of DT-diaphorase in bioreductive drug activation in vitro and in vivo. Sharp SY, Kelland LR, Valenti MR, Brunton LA, Hobbs S, Workman P. Mol Pharmacol; 2000 Nov 06; 58(5):1146-55. PubMed ID: 11040064 [Abstract] [Full Text] [Related]
6. A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent. Winski SL, Hargreaves RH, Butler J, Ross D. Clin Cancer Res; 1998 Dec 06; 4(12):3083-8. PubMed ID: 9865924 [Abstract] [Full Text] [Related]
8. Cytotoxicity of RH1 and related aziridinylbenzoquinones: involvement of activation by NAD(P)H:quinone oxidoreductase (NQO1) and oxidative stress. Nemeikaite-Ceniene A, Sarlauskas J, Anusevicius Z, Nivinskas H, Cenas N. Arch Biochem Biophys; 2003 Aug 01; 416(1):110-8. PubMed ID: 12859987 [Abstract] [Full Text] [Related]
9. Role of NAD(P)H:quinone oxidoreductase 1 (DT diaphorase) in protection against quinone toxicity. Joseph P, Long DJ, Klein-Szanto AJ, Jaiswal AK. Biochem Pharmacol; 2000 Jul 15; 60(2):207-14. PubMed ID: 10825465 [Abstract] [Full Text] [Related]
10. Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development. Phillips RM. Biochem Pharmacol; 1999 Jul 15; 58(2):303-10. PubMed ID: 10423172 [Abstract] [Full Text] [Related]
11. A physiological threshold for protection against menadione toxicity by human NAD(P)H:quinone oxidoreductase (NQO1) in Chinese hamster ovary (CHO) cells. De Haan LH, Boerboom AM, Rietjens IM, van Capelle D, De Ruijter AJ, Jaiswal AK, Aarts JM. Biochem Pharmacol; 2002 Dec 01; 64(11):1597-603. PubMed ID: 12429349 [Abstract] [Full Text] [Related]
13. The role of NAD(P)H: quinone reductase (EC 1.6.99.2, DT-diaphorase) in the reductive bioactivation of the novel indoloquinone antitumor agent EO9. Walton MI, Smith PJ, Workman P. Cancer Commun; 1991 Jul 01; 3(7):199-206. PubMed ID: 1714284 [Abstract] [Full Text] [Related]
14. Measurement of dicumarol-sensitive NADPH: (menadione-cytochrome c) oxidoreductase activity results in an artifactual assay of DT-diaphorase in cell sonicates. Hodnick WF, Sartorelli AC. Anal Biochem; 1997 Oct 01; 252(1):165-8. PubMed ID: 9324955 [Abstract] [Full Text] [Related]
15. Exploring the mechanistic aspects of mitomycin antibiotic bioactivation in Chinese hamster ovary cells overexpressing NADPH:cytochrome C (P-450) reductase and DT-diaphorase. Belcourt MF, Hodnick WF, Rockwell S, Sartorelli AC. Adv Enzyme Regul; 1998 Oct 01; 38():111-33. PubMed ID: 9762350 [Abstract] [Full Text] [Related]
16. Nuclear overexpression of NAD(P)H:quinone oxidoreductase 1 in Chinese hamster ovary cells increases the cytotoxicity of mitomycin C under aerobic and hypoxic conditions. Seow HA, Penketh PG, Belcourt MF, Tomasz M, Rockwell S, Sartorelli AC. J Biol Chem; 2004 Jul 23; 279(30):31606-12. PubMed ID: 15155746 [Abstract] [Full Text] [Related]
17. [DT-diaphorase]. Mikami K, Shirakusa T, Tsuruo T. Gan To Kagaku Ryoho; 1997 Sep 23; 24(11):1606-10. PubMed ID: 9309161 [Abstract] [Full Text] [Related]
18. Dissecting the role of multiple reductases in bioactivation and cytotoxicity of the antitumor agent 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1). Yan C, Kepa JK, Siegel D, Stratford IJ, Ross D. Mol Pharmacol; 2008 Dec 23; 74(6):1657-65. PubMed ID: 18794327 [Abstract] [Full Text] [Related]
19. Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C1. Keyes SR, Fracasso PM, Heimbrook DC, Rockwell S, Sligar SG, Sartorelli AC. Cancer Res; 1984 Dec 23; 44(12 Pt 1):5638-43. PubMed ID: 6437671 [Abstract] [Full Text] [Related]
20. NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity. Traver RD, Horikoshi T, Danenberg KD, Stadlbauer TH, Danenberg PV, Ross D, Gibson NW. Cancer Res; 1992 Feb 15; 52(4):797-802. PubMed ID: 1737339 [Abstract] [Full Text] [Related] Page: [Next] [New Search]