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Journal Abstract Search

897 related items for PubMed ID: 8894508

  • 1. Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes.
    Karam WG, Goldstein JA, Lasker JM, Ghanayem BI.
    Drug Metab Dispos; 1996 Oct; 24(10):1081-7. PubMed ID: 8894508
    [Abstract] [Full Text] [Related]

  • 2. Characterization of CYP2C19 and CYP2C9 from human liver: respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations.
    Lasker JM, Wester MR, Aramsombatdee E, Raucy JL.
    Arch Biochem Biophys; 1998 May 01; 353(1):16-28. PubMed ID: 9578596
    [Abstract] [Full Text] [Related]

  • 3. 5-hydroxylation of omeprazole by human liver microsomal fractions from Chinese populations related to CYP2C19 gene dose and individual ethnicity.
    Shu Y, Wang LS, Xu ZH, He N, Xiao WM, Wang W, Huang SL, Zhou HH.
    J Pharmacol Exp Ther; 2000 Nov 01; 295(2):844-51. PubMed ID: 11046127
    [Abstract] [Full Text] [Related]

  • 4. Different contributions of cytochrome P450 2C19 and 3A4 in the oxidation of omeprazole by human liver microsomes: effects of contents of these two forms in individual human samples.
    Yamazaki H, Inoue K, Shaw PM, Checovich WJ, Guengerich FP, Shimada T.
    J Pharmacol Exp Ther; 1997 Nov 01; 283(2):434-42. PubMed ID: 9353355
    [Abstract] [Full Text] [Related]

  • 5. Probing CYP2C19 and CYP3A4 activities in Chinese liver microsomes by quantification of 5-hydroxyomeprazole and omeprazole sulphone.
    Shu Y, Wang LS, Xiao WM, Wang W, Huang SL, Zhou HH.
    Acta Pharmacol Sin; 2000 Aug 01; 21(8):753-8. PubMed ID: 11501187
    [Abstract] [Full Text] [Related]

  • 6. O-Dealkylation of fluoxetine in relation to CYP2C19 gene dose and involvement of CYP3A4 in human liver microsomes.
    Liu ZQ, Zhu B, Tan YF, Tan ZR, Wang LS, Huang SL, Shu Y, Zhou HH.
    J Pharmacol Exp Ther; 2002 Jan 01; 300(1):105-11. PubMed ID: 11752104
    [Abstract] [Full Text] [Related]

  • 7. CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes.
    Ramírez J, Innocenti F, Schuetz EG, Flockhart DA, Relling MV, Santucci R, Ratain MJ.
    Drug Metab Dispos; 2004 Sep 01; 32(9):930-6. PubMed ID: 15319333
    [Abstract] [Full Text] [Related]

  • 8. Conversion of the HIV protease inhibitor nelfinavir to a bioactive metabolite by human liver CYP2C19.
    Hirani VN, Raucy JL, Lasker JM.
    Drug Metab Dispos; 2004 Dec 01; 32(12):1462-7. PubMed ID: 15448116
    [Abstract] [Full Text] [Related]

  • 9.
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  • 10. The role of CYP2C in the in vitro bioactivation of the contraceptive steroid desogestrel.
    Gentile DM, Verhoeven CH, Shimada T, Back DJ.
    J Pharmacol Exp Ther; 1998 Dec 01; 287(3):975-82. PubMed ID: 9864282
    [Abstract] [Full Text] [Related]

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  • 12. Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes.
    Murayama N, Imai N, Nakane T, Shimizu M, Yamazaki H.
    Biochem Pharmacol; 2007 Jun 15; 73(12):2020-6. PubMed ID: 17433262
    [Abstract] [Full Text] [Related]

  • 13. Confirmation that cytochrome P450 2C8 (CYP2C8) plays a minor role in (S)-(+)- and (R)-(-)-ibuprofen hydroxylation in vitro.
    Chang SY, Li W, Traeger SC, Wang B, Cui D, Zhang H, Wen B, Rodrigues AD.
    Drug Metab Dispos; 2008 Dec 15; 36(12):2513-22. PubMed ID: 18787056
    [Abstract] [Full Text] [Related]

  • 14. CYP2C19 participates in tolbutamide hydroxylation by human liver microsomes.
    Wester MR, Lasker JM, Johnson EF, Raucy JL.
    Drug Metab Dispos; 2000 Mar 15; 28(3):354-9. PubMed ID: 10681382
    [Abstract] [Full Text] [Related]

  • 15. Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes.
    Yamazaki H, Shimada T.
    Arch Biochem Biophys; 1997 Oct 01; 346(1):161-9. PubMed ID: 9328296
    [Abstract] [Full Text] [Related]

  • 16. Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes.
    Abelö A, Andersson TB, Antonsson M, Naudot AK, Skånberg I, Weidolf L.
    Drug Metab Dispos; 2000 Aug 01; 28(8):966-72. PubMed ID: 10901708
    [Abstract] [Full Text] [Related]

  • 17. Human cytochrome P450-catalyzed conversion of the proestrogenic pesticide methoxychlor into an estrogen. Role of CYP2C19 and CYP1A2 in O-demethylation.
    Stresser DM, Kupfer D.
    Drug Metab Dispos; 1998 Sep 01; 26(9):868-74. PubMed ID: 9733665
    [Abstract] [Full Text] [Related]

  • 18. In vitro metabolism of the calmodulin antagonist DY-9760e (3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate) by human liver microsomes: involvement of cytochromes p450 in atypical kinetics and potential drug interactions.
    Tachibana S, Fujimaki Y, Yokoyama H, Okazaki O, Sudo K.
    Drug Metab Dispos; 2005 Nov 01; 33(11):1628-36. PubMed ID: 16049129
    [Abstract] [Full Text] [Related]

  • 19. 16Alpha-hydroxylation of estrone by human cytochrome P4503A4/5.
    Huang Z, Guengerich FP, Kaminsky LS.
    Carcinogenesis; 1998 May 01; 19(5):867-72. PubMed ID: 9635876
    [Abstract] [Full Text] [Related]

  • 20. Reevaluation of the microsomal metabolism of montelukast: major contribution by CYP2C8 at clinically relevant concentrations.
    Filppula AM, Laitila J, Neuvonen PJ, Backman JT.
    Drug Metab Dispos; 2011 May 01; 39(5):904-11. PubMed ID: 21289076
    [Abstract] [Full Text] [Related]

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